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Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock

2012; Wiley; Volume: 56; Issue: 8 Linguagem: Inglês

10.1111/j.1399-6576.2012.02732.x

1399-6576

A. BREIDABLIK, G. H. de Pater, Charles Walther, Anna Nopp, A. B. Guttormsen,

Contact Dermatitis and Allergies

We report a patient with severe anaphylactic shock immediately after injection of i.v. fluorescein. The patient recovered without sequela. Immunoglobulin E ( IgE ) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity ( CD ‐sens) and histamine release tests towards fluorescein. This is, to our knowledge, the first report where CD ‐sens has been used to aid in diagnosing an IgE ‐mediated anaphylactic shock caused by fluorescein.