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ALIS: An Affinity Selection–Mass Spectrometry System for the Discovery and Characterization of Protein–Ligand Interactions

2007; Wiley; Linguagem: Inglês

10.1002/9783527610907.ch3

1865-0562

Allen Annis, Cheng‐Chi Chuang, Naim Nazef,

Mass Spectrometry Techniques and Applications

This chapter contains sections titled: Introduction State of the Art Spectroscopic and Biophysical Methods Mass Spectrometry-based Methods ALIS: An Affinity Selection–Mass Spectrometry System based on Continuous SEC ALIS System Design Discovery of Ligands from Combinatorial Libraries Quantitative Binding Affinity Measurement Theory Simulations and Experimental Results Competition-based Binding Site Determination and Affinity Ranking in Mixtures Binding Site Classification Affinity Ranking in Compound Mixtures Protein–Ligand Dissociation Rate Measurement Theory Simulations Experimental Results Conclusions Future Directions