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Epidemiology of Human Pulmonary Infection with Nontuberculous Mycobacteria

2014; Elsevier BV; Volume: 36; Issue: 1 Linguagem: Inglês

10.1016/j.ccm.2014.10.002

1557-8216

D. Rebecca Prevots, Theodore K. Marras,

Infectious Diseases and Mycology

Population-based data have documented a worldwide increase in the prevalence of human nontuberculous mycobacterial (NTM) infections since 2000. Mycobacterium avium complex is predominant in North America and East Asia, whereas in regions within Europe, M kansasii , M xenopi , and M malmoense are more common. Host factors important to the current epidemiology of NTM pulmonary disease include thoracic skeletal abnormalities , rheumatoid arthritis , and use of immunomodulatory drugs . Clustering of disease within families suggests a heritable genetic predisposition to disease susceptibility. Warm, humid environments with high atmospheric vapor pressure contribute to population risk.