DRUG-INDUCED PEPTIC ULCER
1957; American College of Physicians; Volume: 47; Issue: 4 Linguagem: Romeno
10.7326/0003-4819-47-4-666
ISSN1539-3704
Autores Tópico(s)Pathogenesis and Treatment of Hiccups
ResumoArticle1 October 1957DRUG-INDUCED PEPTIC ULCERJOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P.JOSEPH B. KIRSNER, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-4-666 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe not infrequent occurrence of peptic ulcer in man is perhaps not surprising, considering that the digestive tract, from early life, is subjected to innumerable mechanical, bacterial, chemical, thermal, physiologic, endocrinologic, neurogenic and psychogenic influences.1The relative significance of these factors in the development of peptic ulcer is difficult to assess; each undoubtedly is important. Individual susceptibility also plays a decisive, albeit mysterious rôle, else the incidence of peptic ulcer would greatly exceed the usual estimate of 5 to 10%.2The tendency of certain therapeutic agents to induce gastroduodenal ulceration represents another, increasingly important cause of peptic ulcer in...Bibliography1. KirsnerPalmer JBWL: The problem of peptic ulcer, Am. J. Med. 13: 615, 1952. CrossrefMedlineGoogle Scholar2. IvyGrossmanBachrach ACMEWH: Peptic ulcer, 1950, The Blakiston Co., Philadelphia. Google Scholar3. McCann JC: Experimental peptic ulcer, Arch. Surg. 19: 600, 1929. CrossrefGoogle Scholar4. Selye H: The general adaptation syndrome and peptic ulcer, in Peptic ulcer, Sandweiss, D. J., Editor, 1951, W. B. Saunders Co., Philadelphia, p. 125. Google Scholar5. LamblingHardouinBonfilsLaumonier AJPSR: Ulcère gastrique expérimental, Arch. d. mal. de l'app. digestif. 42: 417, 1953. MedlineGoogle Scholar6. Hanke H: Experimentelle Untersuchungen über bonnonali Ulcerserzeugung. III. Die akute erosive Acetylcholingastritis und ihre Pathogenese, Ztschr. f. d. ges. exper. Med. 95: 77, 1934. CrossrefGoogle Scholar7. HallEttingerBanting GEGHFG: An experimental production of coronary thrombosis and myocardial failure, Canad. M. A. J. 34: 9, 1936. MedlineGoogle Scholar8. Friedman GA: The experimental production of lesions, erosions and acute ulcer in rabbits by repeated injections of pilocarpine and adrenalin, J. Med. Research 38: 440, 1918. Google Scholar9. SelyeLotchleCollip HRLJB: Recent advance in the experimental production of gastric ulcer, Canad. M. A. J. 34: 339, 1936. Google Scholar10. Nedzel AJ: Experimental gastric ulcer (Pitressin episodes), Arch. Path. 26: 988, 1938. Google Scholar11. HaleGrossman EHMI, cited in Peptic ulcer, 1950, by Ivy, Grossman and Bachrach, The Blakiston Co., Philadelphia, p. 432. Google Scholar12. Sheehan D: The hypothalamus and gastrointestinal regulation, A. Research Nerv. and Ment. Dis., Proc. 20: 589, 1940. Google Scholar13. Westphal K: Untersuchungen zur Frage der Nervosen Entstehung. Peptischer Ulcern, Deutsches Arch. f. klin. Med. 114: 327, 1914. Google Scholar14. LightBishopKendall RUCCLB: The production of gastric lesions in rabbits by injection of small amounts of pilocarpine into the cerebrospinal fluid, J. Pharmacol. and Exper. Therap. 45: 227, 1932. Google Scholar15. Mallik KC: An experimental study of the pathogenesis of gastric ulcers produced by pilocarpine, J. Path. and Bact. 70: 315, 1935. CrossrefGoogle Scholar16. WenerHoffSimon JHEMA: Production of gastric and duodenal ulcers by prolonged administration of Mecholyl (methacholine), Gastroenterology 11: 904, 1948. MedlineGoogle Scholar17. WenerKarpHoff JDHE: The effect of Mecholyl in beeswax on gastric secretion, Gastroenterology 11: 923, 1948. MedlineGoogle Scholar18. DoddsHillsNobleWilliams ECGMRLPC: Posterior lobe of the pituitary gland; its relationship to the stomach and to the blood picture, Lancet 1: 1099, 1935. CrossrefGoogle Scholar19. DoddsNobleScarffWilliams ECRLRWPC: Pituitary control of alimentary blood flow and secretion: changes in the stomach by the administration of posterior pituitary extract, Proc. Roy. Soc., London, S. B. 123: 22, 1937. Google Scholar20. Kleitsch WP: Fatal gastric hemorrhage following Aureomycin, Am. J. Digest. Dis. 18: 166, 1951. CrossrefMedlineGoogle Scholar21. Levrat M: Rôle declenchant possible d'un traitement médicamenteux dans l'apparition d'une poussée ulcéreuse chez deux malades atteints d'ulcère de la petite courbure, Arch. d. mal. de l'app. digestif. 42: 26, 1953. Google Scholar22. VachonGrinet AA: Ulcère géant. de la petite courbure apparu an cours d'un traitement per les oestrogènes de synthèse, Arch. d. mal. de l'app. digestif. 42: 608, 1953. MedlineGoogle Scholar23. CodeVarco CFRL: Chronic histamine action, Proc. Soc. Exper. Biol. and Med. 44: 475, 1940. CrossrefGoogle Scholar24. WalpoleWangensteen SHOH: Production of gastric and duodenal ulcers in cat by intramuscular implantation of histamine, Proc. Soc. Exper. Biol. and Med. 44: 619, 1940. CrossrefGoogle Scholar25. HayVarcoCodeWangensteen LJRLCFOH: The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax, Surg., Gynec. and Obst. 75: 170, 1942. Google Scholar26. BaronofskyWangensteen IDOH: Role of nitroglycerin (glyceryl trinitrate) in accelerating occurrence of histamine-provoked ulcer, Proc. Soc. Exper. Biol. and Med. 62: 127, 1946. CrossrefMedlineGoogle Scholar27. Horton BT: Histamine cephalalgia resulting in production of acute duodenal ulcer, J. A. M. A. 122: 59, 1953. Google Scholar28. HortonWagenerAitaWoltman BTHPJAHW: Treatment of multiple sclerosis by intravenous injection of histamine, J. A. M. A. 124: 800, 1944. Google Scholar29. IamsHorton AMBT: An ulcer which appeared in the stomach of a man receiving histamine intravenously, Gastroenterology 6: 449, 1946. MedlineGoogle Scholar30. McHardyBrowne GDC: Duodenal ulcer developing in man following "histamine desensitization," Gastroenterology 2: 345, 1944. Google Scholar31. Judd ES: Experimental production of peptic ulcers with caffeine, Bull. Am. Coll. Surgeons 28: 46, 1943. Google Scholar32. RothIvy JAAC: Caffeine and "peptic" ulcer, Gastroenterology 7: 576, 1946. MedlineGoogle Scholar33. RothIvy JAAC: The experimental production of acute and subacute gastric ulcers in cats by the intramuscular injection of caffeine in beeswax, Gastroenterology 2: 274, 1944. Google Scholar34. Hanke H: Zur Pathogenese der akuten erosiven Gastritis die experimentelle hämatogene Caffein, Arch. f. klin. Chir. 178: 607, 1934. Google Scholar35. Moltini M: Lesioni gastriche da caffeine, Experimental Study, Arch. ital. di chir. 53: 135, 1938. Google Scholar36. RothIvy JAAC: The pathogenesis of caffein-induced ulcers, Surgery 17: 644, 1945. Google Scholar37. WolfWolff SH: Human gastric function, 1943, Oxford University Press, New York. Google Scholar38. RothIvy JAAC: Synergistic effect of caffeine on histamine response, Am. J. Physiol. 142: 107, 1944. CrossrefGoogle Scholar39. RothIvyAtkinson JAACAJ: Caffeine and peptic ulcer, J. A. M. A. 126: 814, 1944. CrossrefGoogle Scholar40. MusickAveyHoppsHellbaum VHATHCAA: Gastric secretion in duodenal ulcer in remission; response to the caffeine test meal, Gastroenterology 7: 332, 1946. MedlineGoogle Scholar41. RothIvy JAAC: Effect of vagotomy and atropine on caffein secretion, Gastroenterology 5: 129, 1945. Google Scholar42. Du BarryAndrau JJR: Étude du chimisme gastrique par l'épreuve de la benzyl-imidazole. Comparison avec l'épreuve a l'histamine, Arch. d. mal. de l'app. digestif. 42: 195, 1953. MedlineGoogle Scholar43. AhlquistHugginsWoodbury RPRARA: The pharmacology of benzyl imidazoline (Priscol), J. Pharmacol. and Exper. Therap. 89: 271, 1947. MedlineGoogle Scholar44. Wilkins RW (a) : Current drug treatment of hypertension, Mod. Concepts Cardiovas. Dis. 22: 198, 1953. (b) Mandelbaum, H., Brook, J., and Mandelbaum, R. A.: Bleeding peptic ulcer complicating hydralazine and hexamethonium bromide therapy, J. A. M. A. 155: 833, 1954. MedlineGoogle Scholar45. ChurchillVan Wagoner TPFH: Cinchophen poisoning, Proc. Soc. Exper. Biol. and Med. 28: 581, 1930-31. CrossrefGoogle Scholar46. Van WagonerChurchill FHTP: Production of gastric and duodenal ulcers in experimental cinchophen poisoning of dogs, Arch. Path. 14: 860, 1932. Google Scholar47. StalkerBollmanMann LKJLFC: Effect of cinchophen on the liver and other tissues of the dog, Proc. Soc. Exper. Biol. and Med. 35: 158, 1936-37. CrossrefGoogle Scholar48. StalkerBollmanMann LKJLFC: Experimental peptic ulcer produced by cinchophen: methods of production, effect of mechanical irritant, and life history of the ulcer, Arch. Surg. 35: 290, 1937. CrossrefGoogle Scholar49. StalkerBollmanMann LKJLFC: Prophylactic treatment of peptic ulcers produced experimentally by cinchophen, Am. J. Digest. Dis. 3: 822, 1936-37. CrossrefGoogle Scholar50. BollmanStalkerMann JLLKFC: Experimental peptic ulcer produced by cinchophen, Arch. Int. Med. 61: 119, 1938. CrossrefGoogle Scholar51. Shoji A: Über die Einfluss von Atophan auf die inneren Organe von Kaninschen und Hund, mit besonderer Berüchsichtigung des Magenschleimhaut, Tr. Soc. Path. Jap. 23: 520, 1933. Google Scholar52. SchwartzSimonds SOJP: Peptic ulcers produced by feeding cinchophen to mammals other than the dog, Proc. Soc. Exper. Biol. and Med. 32: 1133, 1934-35. CrossrefGoogle Scholar53. MageeKimIvy DFKSAC: Cinchophen choleresis and production of peptic ulcer in various species, Proc. Soc. Exper. Biol. and Med. 72: 428, 1949. CrossrefMedlineGoogle Scholar54. Simonds JP: Mode of origin of experimental gastric ulcer induced by cinchophen, Arch. Path. 26: 44, 1938. Google Scholar55. Reah TG: Cinchophen poisoning, Lancet 2: 504, 1932. CrossrefGoogle Scholar56. BlochRosenberg LDH: Gastric ulcers associated with cinchophen poisoning, Am. J. Digest. Dis. 1: 29, 433, 1934. CrossrefGoogle Scholar57. Hueper WC: Cinchophen, Medicine 27: 43, 1948. CrossrefMedlineGoogle Scholar58. Nasio J: Action of vitamin D2 on experimental peptic ulcer produced by cinchophen, Gastroenterology 5: 496, 1945. MedlineGoogle Scholar59. Nasio J: Ulcera peptica cincofenica, Prensa méd. argent. 31: 2609, 1944. Google Scholar60. DavisBradleyBachrachIvy MWWBWHAC: Effect of the Rammstedt operation on the incidence of cinchophen ulcer, Proc. Soc. Exper. Biol. and Med. 45: 66, 1940. CrossrefGoogle Scholar61. WintersPetersCrook MGAGW: Pectin as a prophylactic and curative agent for peptic ulcers produced experimentally with cinchophen, Am. J. Digest. Dis. 6: 12, 1939. CrossrefGoogle Scholar62. MageeKimIvy DFKSAC: Glucuronic acid and cinchophen ulcer, J. Appl. Physiol. 3: 736, 1951. CrossrefMedlineGoogle Scholar63. Repetto A: Lesioni gastriche da canfora, Pathologica 36-39: 86, 1944-47. Google Scholar64. Hollander F: The mucous barrier in the stomach, in Peptic ulcer, Sandweiss, D. J., Editor, 1951, W. B. Saunders Co., Philadelphia, p. 65. Google Scholar65. Hanzlik JP: Actions and uses of the salicylates and cinchophen in medicine, 1927, Williams and Wilkins Co., Baltimore. Google Scholar66. Wyllie AM: A fatal case of aspirin poisoning, Lancet 2: 768, 1935. CrossrefGoogle Scholar67. Neale AV: Aspirin poisoning, Brit. M. J. 1: 109, 1936. CrossrefMedlineGoogle Scholar68. HurstLintott AGA: Aspirin as a cause of haematemesis; a clinical and gastroscopic study, Guy's Hosp. Rep. 89: 173, 1939. Google Scholar69. Martini J: Ulcera subaguda del canal pilorico, Prensa méd. argent. 31: 561, 1944. Google Scholar70. Crismer R (a) : Les hemorragies gastriques proroquees par l'acide acetylsalicylique, Acta clin. belg. 2: 193, 1947. (b) Dumont-Ruyters, L.: Les hemorragies gastroduodenales: diagnostic et traitement, Rev. méd. Liége 3: 546, 1948. CrossrefMedlineGoogle Scholar71. Richmond JA: Idiosyncrasy to aspirin, Brit. M. J. 1: 439, 1950. CrossrefGoogle Scholar72. Waterson AP: Aspirin and gastric hemorrhage, Brit. M. J. 2: 1531, 1955. CrossrefMedlineGoogle Scholar73. LevratRichardAnjou MJA: L'aspirine, facteur declenchant des ulcères gastroduodénaux, Arch. d. mal. de l'app. digestif. 44: 248, 1955. MedlineGoogle Scholar74. Bayo JV: Aspirin and peptic ulcer, Rev. españ. enferm. ap. digest. y nutricion 15: 607, 1956. MedlineGoogle Scholar75. ThompsonDragstedt HECA: Modifying action of calcium and sodium bicarbonate on salicylate intoxication, Arch. Int. Med. 54: 308, 1934. CrossrefGoogle Scholar76. BarbourPorter HGJA: An investigation of the possible protective action of calcium gluconate in aspirin poisoning, J. Pharmacol. and Exper. Therap. 60: 224, 1937. Google Scholar77. BarbourDickerson HGVC: Gastric ulceration produced in rats by oral and subcutaneous aspirin, Arch. internat. de pharmacodyn. et de thérap. 58: 78, 1938. Google Scholar78. ShimamuraAoki MA: Über das durch aspirin hervorgerufene Magenschwür, Folia Pharmacol. Japan (Brev.) 27: 19 (July 20) 1939. Google Scholar79. Hurst A: Aspirin and gastric haemorrhage, Brit. M. J. 1: 768, 1943. CrossrefGoogle Scholar80. BrownMitchell RKN: The influence of some of the salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcer, Gastroenterology 31: 198, 1956. CrossrefMedlineGoogle Scholar81. Kelly JJ: Salicylate ingestion: a frequent cause of gastric hemorrhage, Am. J. M. Sc. 232: 119, 1956. CrossrefMedlineGoogle Scholar82. SchnedorfBradleyIvy JGWBAC: Effect of acetylsalicylic acid upon gastric activity and the modifying action of calcium gluconate and sodium bicarbonate, Am. J. Digest. Dis. 3: 239, 1936. CrossrefGoogle Scholar83. MuirCossar AIA: Aspirin and ulcer, Brit. M. J. 2: 7, 1955. CrossrefMedlineGoogle Scholar84. KirsnerFord JBH: Phenylbutazone (Butazolidin)—studies on the stimulation of gastric secretion and the formation of peptic ulcer in man, Gastroenterology 29: 1, 1955. CrossrefMedlineGoogle Scholar85. VolpatoGiro GM: Salicylates and corticotropic drugs, Chir. Ital. 8: 291, 1955-56. MedlineGoogle Scholar86. MeadeSmith BWMJ: Salicylate, gentisate and circulating eosinophils, Lancet 1: 773, 1951. CrossrefMedlineGoogle Scholar87. RoskamVan Cauwenberge JH: Effect of sodium salicylate on circulating eosinophils and urinary uric acid: creatinine ratio in healthy volunteers, Lancet 2: 375, 1951. CrossrefMedlineGoogle Scholar88. BaylissSteinbeck RIAW: Salicylates and the plasma level of adrenal steroids, Lancet 1: 1010, 1954. CrossrefGoogle Scholar89. SmithGrayLunnon MJCHJB: Urinary excretion of adrenocortical steroids by patients receiving salicylates, Lancet 1: 1008, 1954. CrossrefGoogle Scholar90. Smith MJ: Antagonistic effects of cortisone and salicylate, Nature, London 170: 240, 1952. CrossrefMedlineGoogle Scholar91. Smith MJ: Some recent advances in the pharmacology of salicylates, J. Pharm. and Pharmacol. 5: 81, 1953. CrossrefMedlineGoogle Scholar92. Paul WD: The effect of acetylsalicylic acid (aspirin) on the gastric mucosa, a gastroscopic study, J. Iowa M. Soc. 33: 155, 1943. Google Scholar93. Caravati CM: Gastric endoscopic and secretory findings during salicylism, Gastroenterology 6: 7, 1946. MedlineGoogle Scholar94. DouthwaiteLintott AHGA: Gastroscopic observations of the effect of aspirin and certain other substances on the stomach, Lancet 2: 1222, 1938. CrossrefGoogle Scholar95. BeckBrowneJohnsonKennedyMacKenzie JCJSLGGJDW: Occurrence of peritonitis during ACTH administration, Canad. M. A. J. 62: 423, 1950. MedlineGoogle Scholar96. HabifHareGlaser DVCCGH: Perforated duodenal ulcer after ACTH therapy, J. A. M. A. 144: 996, 1950. CrossrefMedlineGoogle Scholar97. Smyth GA: Activation of peptic ulcer during pituitary adrenocorticotropic hormone therapy, J. A. M. A. 145: 474, 1951. CrossrefMedlineGoogle Scholar98. LukinMisbackZemkeHammarstenHeller RIWDEMJFBI (a) : Acute perforation of duodenal ulcer during ACTH and cortisone therapy, Gastroenterology 18: 308, 1951. (b) Sloan, S., Briggs, C. O., and Halsted, J. A.: ACTH therapy for ulcerative colitis complicated by perforation of co-existing peptic ulcer, Gastroenterology 18: 438, 1951. CrossrefMedlineGoogle Scholar99. Moe AE (a) : Gastric ulcer appearing during cortisone administration, Gastroenterology 20: 343, 1952. (b) Bulova, P. N., Becker, G. P., and Maslow, M.: Gastroduodenal ulcer following cortisone therapy: report of a case with fatal hemorrhage, New York State J. Med. 52: 1181, 1952. CrossrefMedlineGoogle Scholar100. Hall BD: Gastric ulcer associated with cortisone therapy, Gastroenterology 65: 80, 1953. CrossrefGoogle Scholar101. Goldberg MB (a) : Experience with long-term cortisone therapy in congenital adrenocortical hyperplasia, J. Clin. Endocrinol. and Metabolism 14: 389, 1954. (b) Copeman, W. S. C., Savage, O., Dodds, C., Glyn, J. H., and Fearnley, M. E.: Management of rheumatoid arthritis with prolonged cortisone administration, Brit. M. J. 1: 1109, 1954. CrossrefGoogle Scholar102. UlinCancelmo AWJB (a) : Stress syndrome and perforated peptic ulcer, Surgery 35: 640, 1954. (b) Bachman, K. P., and Rogers, C. E.: Perforated gastric ulcer and gastrocolic fistula associated with prolonged cortisone therapy, U. S. Armed Forces M. J. 6: 109, 1955. MedlineGoogle Scholar103. BaroodyShugart WGRT: The simultaneous occurrence of duodenal and gastric ulcer during therapy with ACTH, Am. Pract. 6: 1875, 1955. Google Scholar104. Zimmer FE: Difficulties encountered in the therapeutic use of cortisone and ACTH, Am. Pract. and Digest. Treat. 5: 511, 1954. MedlineGoogle Scholar105. DebrayHardouisLaumonierCerfMartin CJPRME: Gastroduodenal ulcer during treatment with delta cortisone, Semaine d. hop. Paris 32: 3616, 1956. Google Scholar106. Finck PA: Cortisone overdosage in rheumatoid arthritis, Arch. Path. 60: 374, 1955. Google Scholar107. EdwardsWollgast JAGF: The danger of peptic ulcer complications during cortisone or ACTH therapy, Rocky Mountain M. J. 52: 734, 1953. Google Scholar108. SauerDearingWollaeger WGWHEE: Serious untoward gastrointestinal manifestations possibly related to administration of cortisone and corticotropin, Proc. Staff Meet., Mayo Clin. 28: 641, 1953. MedlineGoogle Scholar109. Boland EW: Preliminary clinical experience with metacortandracin in rheumatoid arthritis, in Koch, G.: First International Conference on Clinical and Metabolic Effects of Meticorten and Meticortelone, 1955, Georgian Press, New York, pp. 1-14. Google Scholar110. Granirer LW: Sudden perforation of an asymptomatic duodenal ulcer in a patient on prednisone therapy, New York State J. Med. 56: 2855, 1906. Google Scholar111. MerklenMelbeHarter FPGRP: Perforation d'ulcus duodenal au cours du traitement d'un lupus erythemateux subaigu par la metacortendraine, Presse méd. 64: 681, 1956. Google Scholar112. Pickert H: Ulcusperforation unter Prednisone-Behandlung einer diffusen Sklerodermie, Arztl. Wchnschr. 11: 328, 1956. MedlineGoogle Scholar113. RothermichPhilips NOVK: Prednisone and prednisolone therapy in rheumatoid arthritis. A gastrointestinal hazard? Ohio State M. J. 52: 942, 1956. MedlineGoogle Scholar114. GrayRamseyThorn SJCGGW: Adrenal influences on the stomach: peptic ulcer in Addison's disease during adrenal steroid therapy, Ann. Int. Med. 45: 73, 1956. LinkGoogle Scholar115. GriepBuchholz AHRR: Perforation of chronic duodenal ulcer during cortisone therapy for Addison's disease, Am. J. Surg. 85: 703, 1953. CrossrefMedlineGoogle Scholar116. GrayBensonReifensteinSpiro SJJARWHM: Chronic stress and peptic ulcer, J. A. M. A. 147: 1529, 1951. CrossrefMedlineGoogle Scholar117. GrayRamseyReifensteinBenson SJCRWJA: The significance of hormonal factors in the pathogenesis of peptic ulcer, Gastroenterology 25: 156, 1953. CrossrefMedlineGoogle Scholar118. Engel FL: Addison's disease and peptic ulcer, J. Clin. Endocrinol. 15: 1310, 1955. CrossrefGoogle Scholar119. Halsted JA: The effects of ACTH and cortisone in diseases of the digestive system, M. Clin. North America 32: 1069, 1952. CrossrefGoogle Scholar120. HollanderMote JLJR: Proceedings of the Second Clinical ACTH Conference, Vol. 2, Therapeutics, 1951, The Blakiston Co., Philadelphia, pp. 503-504. Google Scholar121. StreetenPollard DHHM, reported at the Pan-American Congress of Gastroenterology, Havana, Cuba, January, 1956. Google Scholar122. Sandweiss DJ: Effects of adrenocorticotropic hormone (ACTH) and of cortisone on peptic ulcer. I. Clinical review, Gastroenterology 27: 604, 1954. CrossrefMedlineGoogle Scholar123. Wollaeger EE: Untoward effects of cortisone and corticotropin on gastrointestinal tract, Minnesota Med. 37: 626, 1954. MedlineGoogle Scholar124. Henderson E: New developments in steroid therapy of rheumatic diseases, J. M. Soc. New Jersey 52: 609, 1955. MedlineGoogle Scholar125. Henderson E: Personal communications, March, 1957. Google Scholar126. DollJones RFA: Occupational factors in the aetiology of gastric and duodenal ulcer, Medical Research Council Special Report Series No. 276, 1951. Google Scholar127. KirsnerKassrielPalmer JBRSWL: Peptic ulcer, in Advances in internal medicine, Vol. VIII, 1956, Year Book Publications, Chicago. Google Scholar128. Ragan C: Proceedings of the Conference on the Effects of Cortisone, 1952, Merck and Co., Inc., Rahway, N. J., p. 55. Google Scholar129. Bauer W: Proceedings of the Conference on the Effects of Cortisone, Dec. 10, 1951, 1952, Merck and Co. Rahway, N. J., p. 56. Google Scholar130. KernClarkLukens FGMJC: Peptic ulceration occurring during therapy for rheumatoid arthritis, Gastroenterology, to be published. Google Scholar131. FreybergTraegerPattersonSquiresAdamsStevenson RHCHMWCHC: Problems of prolonged cortisone treatment for rheumatoid arthritis. Further investigations, J. A. M. A. 147: 1538, 1951. CrossrefMedlineGoogle Scholar132. BunimZiffMcEwen JJMC: Evaluation of prolonged cortisone therapy in rheumatoid arthritis, Am. J. Med. 18: 27, 1955. CrossrefMedlineGoogle Scholar133. HowellRagan DSC: The course of rheumatoid arthritis during four years of induced hyperadrenalism (IHA), Medicine 35: 83, 1956. CrossrefMedlineGoogle Scholar134. Boland EW: Prednisone and prednisolone therapy in rheumatoid arthritis, J. A. M. A. 160: 613, 1956. CrossrefMedlineGoogle Scholar135. FentressFirnschildReveno VPWS: Perforated duodenal ulcer complicating prednisone therapy, New England J. Med. 254: 657, 1956. CrossrefMedlineGoogle Scholar136. HurlburtRobinson FWCE: Long-term cortisone therapy in rheumatoid arthritis, Canad. M. A. J. 70: 245, 1954. Google Scholar137. WestNewn HFJR: Treatment of rheumatoid arthritis by prolonged stimulation of the adrenal cortex, Lancet 1: 578, 1955. CrossrefGoogle Scholar138. TooneIrby ECR: Effect of cortisone in the long-term treatment of rheumatoid arthritis, Am. J. Med. 18: 41, 1955. CrossrefMedlineGoogle Scholar139. LowellSchillerLeardFranklin FCIWDEW: Prolonged treatment of bronchial asthma with cortisone, J. Allergy 24: 112, 1953. CrossrefMedlineGoogle Scholar140. ArbesmanRichard CENB: Prolonged cortisone and hydrocortisone therapy, J. Allergy 25: 306, 1954. CrossrefMedlineGoogle Scholar141. SavidgeBrockbank RSW: Long-term control of severe bronchial asthma with oral cortisone, Lancet 2: 889, 1954. CrossrefGoogle Scholar142. WolfsonQuinnSpearman WQJRWF: Corticoid therapy in eye diseases, Arch. Int. Med. 95: 400, 1955. CrossrefGoogle Scholar143. ReznickLeverFrazier LWFCN: Treatment of pemphigus with ACTH, cortisone and prednisone: results obtained in twenty-five cases over a period of five years, New England J. Med. 255: 305, 1956. CrossrefMedlineGoogle Scholar144. KirsnerPalmer JBWL: Ulcerative colitis: considerations of its etiology and treatment, J. A. M. A. 158: 351, 1954. Google Scholar145. KirsnerSklarPalmer JBMWL: The effect of ACTH and adrenal steroids in the management of ulcerative colitis. Observations on 180 patients, Am. J. Med. 22: 264, 1957. CrossrefMedlineGoogle Scholar146. TrueloveWitts SCCJ: Cortisone in ulcerative colitis, Brit. M. J. 2: 4947, 1955. Google Scholar147. MaltbyDirksonO'Sullivan EJRCPM: The use of ACTH and cortisone in idiopathic ulcerative colitis, Canad. M. A. J. 74: 4, 1956. MedlineGoogle Scholar148. Brick IB: Drugs for arthritis. Correspondence, J. A. M. A. 160: 1168, 1956. CrossrefGoogle Scholar149. Machella TE: Personal communication, 1957. Google Scholar150. MillerSandweiss PBDJ: Perforation of a post-gastrectomy stomal ulcer during cortisone therapy, Gastroenterology 31: 399, 1956. CrossrefMedlineGoogle Scholar151. Kammerer WH: Personal communication, March, 1957. Google Scholar152. Neustadt DH: Proc. American Rheumatism Assoc. June 1956; Ann. Rheum. Dis. 15: 397, 1956. Google Scholar153. Dubois EL: Prednisone and prednisolone in the treatment of systemic lupus erythematosus, J. A. M. A. 161: 427, 1956. CrossrefMedlineGoogle Scholar154. CarboneLiebowitzForsham JVDPA: Suppression of prednisone-induced hypersecretion by an anticholinergic drug, Proc. Soc. Exper, Biol. and Med. 94: 293, 1957. CrossrefMedlineGoogle Scholar155. KirsnerBockPalmerLevinFord JBDWHEH: Variations in basal gastric secretion in man and the evaluation of gastric secretory stimulants, Gastroenterology 30: 779, 1956. CrossrefMedlineGoogle Scholar156. Kirsner JB: The effects of ACTH and adrenal steroids upon gastric secretion in man, to be published. Google Scholar157. DreilingJanowitz DAHD: The effects of ACTH and adrenal steroid hormones on gastric secretion, Clin. Res. Proc. 5: 110, 1957. Google Scholar158. HirschowitzStreetenLondonPollard BIDHJHM: The effects of eight-hour intravenous infusion of ACTH and the adrenocortical steroids in normal man. I. Basal gastric secretion and plasma and urinary pepsinogen, J. Clin. Investigation 36: 1171, 1957. CrossrefMedlineGoogle Scholar159. KammererRivelis WHAL: Effects of hydrocortisone, prednisone and prednisolone on gastric secretion in humans, Ann. Rheumat. Dis. 15: 397, 1956. Google Scholar160. VillarrealGanongGray RWFSJ: Effect of adrenocorticotropic hormone upon the gastric secretion of hydrochloric acid, pepsin, and electrolytes in the dog, Am. J. Physiol. 183: 485, 1955. CrossrefMedlineGoogle Scholar161. Beyer K: Personal communication, 1957. Google Scholar162. WelbourneCode RBCF: Effects of cortisone and of adrenalectomy on secretion of gastric acid and on occurrence of gastric ulceration in the pylorus-ligated rat, Gastroenterology 25: 356, 1953. CrossrefGoogle Scholar163. ZubiranKarkDragstedt JMAELR: The effect of ACTH on gastric secretion in experimental animals, Gastroenterology 21: 276, 1952. CrossrefMedlineGoogle Scholar164. ZubiranKarkMontalbeltiMorelDragstedt JMAEAJCJLR: Peptic ulcer and the adrenal stress syndrome, Arch. Surg. 65: 809, 1952. CrossrefGoogle Scholar165. RaginsDragstedtLandorLyonDragstedt HLRJHESLR: Duodenal ulcer and the hypophysis—adrenal stress mechanism, Surgery 40: 886, 1956. MedlineGoogle Scholar166. Ragins H: Personal communication, November, 1956. Google Scholar167. Hollander F: Personal communication, March, 1957. Google Scholar168. Van GoidsenhovenWilkoffKirsner GLJB: Urine and serum pepsinogen and gastric pepsin in normal individuals, patients with gastric ulcer, duodenal ulcer and achlorhydria, Gastroenterology, to be published. Google Scholar169. WoodwardSchapiroArmstrong ERHG: Relation between uropepsin excretion and secretion of gastric juice, J. Appl. Physiol. 8: 643, 1955-56. CrossrefGoogle Scholar170. Turner FP: Eosinophil responses to epinephrine and ACTH in peptic ulcer, Gastroenterol. 18: 419, 1951. CrossrefMedlineGoogle Scholar171. Foti M: Magenschwürprobleme, Stress und Nervensystem, Deutsche Ztschr. Verdauungskr. 14: 240, 1954. Google Scholar172. Hetenyi G: Neurohormonal influences in the genesis of peptic ulcer, Schweiz, med. Wchnschr. 80: 1032, 1950. MedlineGoogle Scholar173. BiroNagy LG: Beziehungen zwischen Ulkuskrankheit und Nebenniere, Gastroenterologia 76: 169, 1950-51. CrossrefMedlineGoogle Scholar174. SandweissSaltzsteinScheinbergParks DJHCSRA: Hormone studies in peptic ulcer, J. A. M. A. 144: 1436, 1950. CrossrefMedlineGoogle Scholar175. RozenbojmKrakauerGray JLJSJ: Adrenocortical hyperactivity as determined by plasma and urinary 17-hydroxycorticosteroid levels, Clin. Res. Proc. 4: 131 (Apr.) 1956. Google Scholar176. Freeman S: Meeting, Gastroenterology Research Group, Chicago, Ill., November, 1956. Google Scholar177. CumminsKeyesJones AJHEMH: Plasma 17-hydroxycorticoids in peptic ulcer disease, Clin. Res. Proc. 4: 131, 1956. Google Scholar178. CumminsGompertzJones AJMLMH: Urinary excretion of 17-hydroxycorticosteroids in peptic ulcer disease, Clin. Res. Proc. 5: 111, 1957. Google Scholar179. Kirsner JB: Hormones and peptic ulcer, Bull. New York Acad. Med. 29: 477, 1953. MedlineGoogle Scholar180. KyleLoganNeillWelbourne JJSDWRB: Influence of the adrenal cortex on gastric secretion in man, Lancet 1: 664, 1956. CrossrefGoogle Scholar181. KyleWelbourne JRB: The influence of the pituitary and adrenal glands on gastric secretion, Gastroenterologia 85: 205, 1956. CrossrefMedlineGoogle Scholar182. HirschowitzStreetenPollardBolt BIDHHMRA: The role of the gastric secretion in the activation of peptic ulcer by ACTH, J. A. M. A. 158: 27, 1955. CrossrefMedlineGoogle Scholar183. SandweissScheinbergSaltzstein DJSRHC: Effect of adrenocorticotropic hormone (ACTH) and of cortisone on peptic ulcer. II. Experimental studies on Mann-Williamson dogs, Gastroenterology 27: 617, 1954. CrossrefMedlineGoogle Scholar184. DeutschToddHayward EJJRM: ACTH and cortisone therapy for recurrent massive gastric hemorrhage after subtotal gastrectomy, New England J. Med. 254: 363, 1956. CrossrefMedlineGoogle Scholar185. CramerNadel LMEM: Effect of prednisone upon gastric wound healing, Am. J. Path. 32: 659, 1956. Google Scholar186. TinozziDozio FPG: The effects of ACTH and cortisone on gastroduodenal ulcer: experimental study, Minerva chir. 11: 699, 1956. MedlineGoogle Scholar187. LucheriniGospodinoff TA: On the ulcerogenic effect of the new synthetic steroids: experimental study and comparison with other anti-rh
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