NF‐ κ B activation in melanoma
2006; Wiley; Volume: 19; Issue: 2 Linguagem: Inglês
10.1111/j.1600-0749.2006.00304.x
ISSN1600-0749
Autores Tópico(s)RNA regulation and disease
ResumoSummary Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor‐kappa B (NF‐ κ B) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF‐ κ B, (ii) mechanisms by which activated NF‐ κ B switch from pro‐apoptotic to anti‐apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF‐ κ B in metastatic melanoma.
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