Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus.
1983; Elsevier BV; Volume: 258; Issue: 7 Linguagem: Inglês
10.1016/s0021-9258(18)32579-1
ISSN1083-351X
AutoresSilvia N.J. Moreno, Ronald P. Mason, R. P. A. Muniz, Fernando S. Cruz, Roberto Docampo,
Tópico(s)Insect and Pesticide Research
ResumoMetronidazole, ronidazole, secnidazole, benznidazole, and misonidazole are reduced by intact Tritrichomonas foetus cells to nitro anion radicals that can be detected by electron spin resonance spectroscopy. This activity appears to be related to the cellular content of reducing substrates, since nitro anion radical formation is stimulated in the presence of glucose and pyruvate. The nitro anion radicals could not be detected under aerobic conditions. Anaerobic homogenates of T. foetus also reduce metronidazole to the nitro anion radical when pyruvate, NADH, or NADPH is added as the ultimate source of reducing equivalents. Free radical formation may be the basic cause of nitroimidazole toxicity in trichomonads.
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