TriMatch comparison of the efficacy of FloSeal versus TachoSil versus no hemostatic agents for partial nephrectomy: Results from a large multicenter dataset
2014; Wiley; Volume: 22; Issue: 1 Linguagem: Inglês
10.1111/iju.12603
ISSN1442-2042
AutoresAlessandro Antonelli, Andrea Minervini, Andrea Mari, Riccardo Bertolo, Giampaolo Bianchi, A. Lapini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Giuseppe Morgia, Giacomo Novara, F. Porpiglia, Bernardo Rocco, B. Rovereto, Riccardo Schiavina, Claudio Simeone, M. Sodano, Carlo Terrone, Vincenzo Ficarra, Marco Carini, Sergio Serni,
Tópico(s)Bladder and Urothelial Cancer Treatments
ResumoObjectives To evaluate the efficacy of hemostatic agents, TachoSil and FloSeal , during partial nephrectomy using a large multicenter dataset. Methods Data of 1055 patients who underwent partial nephrectomy between J anuary 2009 and D ecember 2012 in 19 I talian centers were collected within an observational multicentric study ( RECORd P roject). The decision whether or not to use hemostatic agents after renorrhaphy and the type of hemostatic agents applied was adopted according to the centers' and surgeons' preference. A T ri M atch propensity score analysis was applied to balance three study groups (no hemostatic agents, TachoSil , FloSeal ) for sex, age, surgical indication (elective/relative vs imperative), clinical stage ( cT1a vs cT1b ), tumor exophyticity, approach (open vs minimally invasive), technique (standard partial nephrectomy vs simple enucleation), preoperative hemoglobin and creatinine. Postoperative complications and variation of hemoglobin and creatinine values between preoperative versus third postoperative day were compared. Results Tri M atch analysis allowed us to obtain 66 well‐balanced triplets. No differences were found in terms of outcomes between the study groups. Conclusions The present findings suggest that adding hemostatic agents to renorraphy during partial nephrectomy does not provide better surgical outcomes.
Referência(s)