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Human T h17 subsets

2012; Wiley; Volume: 42; Issue: 9 Linguagem: Inglês

10.1002/eji.201242741

1521-4141

Federica Sallusto, Christina E. Zielinski, Antonio Lanzavecchia,

Immune Cell Function and Interaction

Since their discovery as a distinct T helper ( T h) cell lineage, T h17 cells have been extensively investigated both in mice and in humans. These studies have identified factors involved in their differentiation and effector functions and have also revealed a high degree of flexibility that seems to be a characteristic of the T h17‐cell lineage. In this review, we discuss recent studies addressing the heterogeneity of human T h17 cells, their differentiation requirements, their migratory capacities, and their role in defense against fungi and extracellular bacteria.