Antigenic Relationships between Influenza B/Hong Kong/72 Strains and B/Seattle/1/49
1984; Volume: 58; Issue: 4 Linguagem: Inglês
10.11150/kansenshogakuzasshi1970.58.275
ISSN1884-569X
Autores Tópico(s)Virus-based gene therapy research
ResumoPre-epidemic HI antibody against the B/Hong Kong/72 influenza virus was present in 34 to 70% of sera from persons aged more than 20 living in Saitama prefecture. The percentage of age-distribution of its antibody was the highest in persons aged 25-29 and high titers of its antibody were present in those persons too. These persons showed good correlation between their B/Hong Kong/72 and B/Seattle/1/49 antibodies. These findings suggest that the hemagglutinins of B/Hong Kong/72 virus are closely related to those of the B/Bon virus that prevailed in the 1943-52.B/Seattle/1/49 showed clear cross-reaction with B/Hong Kong/72 strains in hemagglutination inhibition tests with chicken antisera, and it was found by cross-absorption tests of HI antibodies in chicken antisera that the common antigen between B/Seattle/1/49, B/Yamagata/1/73 and B/Gifu/2/73 viruses was contained in major antigens of B/Hong Kong/72 viruses. However, the hemagglutinin of B/Osaka/2/70 did not contain this common antigenic factor.The findings constitute an example of antigenic recycling after a long period of abcence, and support the view that the number of influenza B virus is finite.
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