Portal de Periódicos da CAPES

THE CLINICAL APPLICATION OF PITUITARY ADRENOCORTICOTROPIC AND ADRENAL STEROID HORMONES

1951; American College of Physicians; Volume: 35; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-35-3-615

1539-3704

L W KINSELL,

Veterinary Medicine and Surgery

Article1 September 1951THE CLINICAL APPLICATION OF PITUITARY ADRENOCORTICOTROPIC AND ADRENAL STEROID HORMONESLAURANCE W. KINSELL, M.D., F.A.C.P.LAURANCE W. KINSELL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-615 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBACKGROUND AND FUNDAMENTAL CONCEPTSThe history of the pituitary-adrenal system, at least from the standpoint of the clinical physiologist, may be divided arbitrarily into three periods. Thefirstbegan with the masterly description by Thomas Addison1in 1855 of the disease which has since borne his name, and with the demonstration a year later by Brown-Séquard2that extirpation of the adrenals in laboratory animals resulted in the death of the animals. Thesecond, or period of intensive experimentation, had its inception with the demonstration in 1927, by Hartman, MacArthur and Hartman,3and by Rogoff and Stewart,4independently, that adrenal cortical...Bibliography1. Addison T: On the constitutional and local effects of disease of the suprarenal capsules, 1855, S. Highley, London. Google Scholar2. Brown-Séquard E: La physiologie et la pathologie des capsules surrenales, Arch. gén. de méd. 8: 385, 1856. Google Scholar3. HartmanMacArthurHartman FACGWE: A substance which prolongs the life of adrenalectomized cats, Proc. Soc. Exper. Biol. and Med. 25: 69, 1927. CrossrefGoogle Scholar4. RogoffStewart JMGN: The influence of adrenal extracts on the survival period of adrenalectomized animals, Science 66: 327, 1927. CrossrefMedlineGoogle Scholar5. HenchKendallSlocumbPolley PSEDCHHF: The effects of a hormone of the adrenal cortex (17-hydroxydehydrocorticosterone; compound E) and of pituitary adrenotropic hormone, on rheumatoid arthritis, preliminary report, Proc. Staff Meet., Mayo Clin. 24: 181, 1949. MedlineGoogle Scholar6. Albright F: Cushing's syndrome: its pathological physiology. Its relationship to the adreno-genital syndrome, and its connection with the problem of the reaction of the body to injurious agents ("alarm reaction" of Selye), The Harvey Lecture Series, XXXVIII, 123, 1942-43. Google Scholar7. FinlandKassIngbar MEHSHa. : Effects of ACTH in primary atypical (viral) pneumonia and in pneumococcal pneumonia (preliminary report), Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. b. Kass, E. H., Ingbar, S. H., and Finland, M.: Effects of adrenocorticotropic hormone in pneumonia: clinical, bacteriological and serological studies, Ann. Int. Med. 33: 1081-1098 (Nov.) 1950. Google Scholar8. DoughertyWhite TFAa. : Influence of hormones on lymphoid tissue, structure and function. The role of the pituitary adrenotropic hormone and the regulation of the leucocytes and other cellular elements of the blood, Endocrinology 35: 1-14, 1944. b. Dougherty, T. F., and White, A.: An evaluation of alterations produced in lymphoid tissue by pituitary-adrenocortical secretion, J. Lab. and Clin. Med. 32: 584-605, 1947. CrossrefGoogle Scholar9. BordleyHarveyHowardNewman JEAMJEEV: Preliminary report on the use of ACTH in the hypersensitive state, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. Google Scholar10. RandolphRollins TGJP: Relief of allergic diseases by ACTH therapy, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. Google Scholar11. Rose B: Studies on the effect of ACTH on eosinophilia and bronchial asthma, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. Google Scholar12. RoseParePumpStanfordJohnson BJAKRLGa. : Influence of ACTH on the excretion of histamine and histidine in patients with allergic states or rheumatoid arthritis, Program 42nd Annual Meeting, Am. Soc. Clin. Investigation, May 1, 1950, p. 51 (advance abstract). b. Carryer, H. M., Koelsche, G. A., Prickman, L. E., Maytum, C. K., Lake, C. F., and Williams, H. L.: The effect of cortisone on bronchial asthma and hay fever resulting from ragweed pollen sensitivity, J. Allergy 21: 259-260 (May) 1950 (in Soc. Proc.). c. Randolph, T. G., and Rollins, J. P.: Concentrated adrenal cortex extract: its effect in bronchial asthma and gastrointestinal allergy, Ann. Allergy 8: 169-174, 187 (March-April) 1950. d. Kanee, B., Grant, J. H. B., Mallek, J., and Eden, J.: ACTH in atopic dermatitis (infantile eczema) and asthma, Canad. M. A. J. 62: 428-431 (May) 1950. e. Franklin, W., and Lowell, F. C.: Treatment of bronchial asthma, Am. Practitioner and Digest of Treatment 1: 1161-1168 (Nov.) 1950. f. Carey, R. A., Harvey, A. M., Howard, J. E., and Wagley, P. F.: The effect of adrenocorticotropic hormone (ACTH) and cortisone on drug hypersensitivity reactions, Bull. Johns Hopkins Hosp. 87: 354-386 (Nov.) 1950. g. Carey, R. A., Harvey, A. M., Howard, J. E., and Winkenwerder, W. L.: The effect of adrenocorticotropic hormone (ACTH) and cortisone on the course of chronic bronchial asthma, Bull. Johns Hopkins Hosp. 87: 387-414 (Nov.) 1950. Google Scholar13. LongFavour JBCB: The ability of ACTH and cortisone to alter delayed type bacterial hypersensitivity, Bull. Johns Hopkins Hosp. 87: 186-202 (Sept.) 1950. MedlineGoogle Scholar14. ThornForshamFrawleyHillRocheStaehelinWilson GWPHTFSRMDDL: Medical progress. The clinical usefulness of ACTH and cortisone, New England J. Med. 242: 783-793, 1950. CrossrefMedlineGoogle Scholar15. KinsellMargen LWS: Unpublished data. Google Scholar16. ThornForshamPruntyHills GWPHFTAG: A test for adrenal cortical insufficiency, J. A. M. A. 137: 1005-1009, 1948. CrossrefMedlineGoogle Scholar17. ThornForshamEmerson GWPHKa. : The diagnosis and treatment of adrenal insufficiency, 1949, Charles C. Thomas, Springfield, Ill. b. Kinsell, L. W.: Unpublished data. Google Scholar18. Salassa RM: Effect of cortisone and ACTH in certain endocrine conditions, Proc. Staff Meet., Mayo Clin. 25: 497-498, 1950. MedlineGoogle Scholar19. BolingNewkirkBaxterMargenKinsell LJPSLW: The use of ACTH and cortisone in the management of acute abdominal emergencies, Proc. Assn. for Study of Int. Secr., June, 1951. Google Scholar20. SmadelLeyDiercks JEHLFHa. : Treatment of typhoid fever. I. Combined therapy with cortisone and chloramphenicol, Ann. Int. Med. 34: 1-9 (Jan.) 1951. b. Woodward, T. E., Hall, H. E., Diaz-Rivera, R., Hightower, J. A., Martinez, E., and Parker, R. T.: Treatment of typhoid fever. II. Control of clinical manifestations with cortisone, Ann. Int. Med. 34: 10-19 (Jan.) 1951. LinkGoogle Scholar21. Whitelaw MJ: Physiological reaction to pituitary adrenocorticotropic hormone (ACTH) in severe burns, J. A. M. A. 145: 85-38, 1951. CrossrefMedlineGoogle Scholar22. OlsonSteffensenMargulisSmithWhitney JAEHRRRWEL: Effects of ACTH on certain inflammatory diseases of the eye: a preliminary report, J. A. M. A. 142: 1276-1278 (April 22) 1950. CrossrefGoogle Scholar23. JonesMeyer ISKa. : Inhibition of vascularization of the rabbit cornea by local application of cortisone, Proc. Soc. Exper. Biol. and Med. 74: 102-104 (May) 1950. b. Henderson, J. W., and Hollenhorst, H. W.: Clinical observations on the use of cortisone in ophthalmic diseases: preliminary report, Proc. Staff Meet., Mayo Clin. 25: 459-462 (Aug. 2) 1950. c. Steffensen, E. H., Olson, J. A., Margulis, R. R., Smith, R. W., and Whitney, E. L.: The experimental use of cortisone in inflammatory eye disease, Am. J. Ophth. 33: 1033-1040 (July) 1950. d. Henderson, J. W., and Hollenhorst, R. W.: Effects of cortisone on certain ophthalmic diseases, Proc. Staff Meet., Mayo Clin. 25: 490-491 (Aug. 16) 1950. e. Koff, R., Rome, S., Kasper, R., Commons, R. R., Button, R., and Starr, P.: Subconjunctival injection of cortisone in iritis, J. A. M. A. 144: 1259-1260 (Dec. 9) 1950. f. Woods, A. C., and Wood, R. M.: The action of ACTH and cortisone on experimental ocular inflammation, Bull. Johns Hopkins Hosp. 87: 482-504 (Nov.) 1950. g. Harvey, A. M., Howard, J. E., and Kattus, A. A.: The effect of adrenocorticotropic hormone (ACTH) and cortisone on certain diseases of the eye in which hypersensitivity plays a role, Bull. Johns Hopkins Hosp. 87: 461-481 (Nov.) 1950. h. Hogan, M.: Cortisone in eye disorders, Bull. Univ. of California M. Center 11: 17-24 (Oct.) 1950. i. Editorial (Brandenburg, K. C.): Stress and ophthalmology, Ann. West. Med. and Surg. 4: 842 (Dec.) 1950. j. Mazar, S. A., and Bogdassarian, R. M.: Adrenocorticotropic hormone: its successful use in keratitis in a diabetic with moderate heart disease, J. A. M. A. 144: 1369-1371 (Dec. 16) 1950. k. Rome, S., Koff, R., Kasper, R., Button, R., Commons, R., and Starr, P.: ACTH and cortisone in ocular inflammation, parenteral and local use, Ann. West. Med. and Surg. 4: 799-804 (Dec.) 1950. CrossrefMedlineGoogle Scholar24. WilkinsLewisKleinRosenberg LRARE: The suppression of androgen secretion by cortisone in a case of congenital adrenal hyperplasia: preliminary report, Bull. Johns Hopkins Hosp. 86: 249-252 (April) 1950. MedlineGoogle Scholar25. SegalHerschfus MSJA: ACTH and cortisone in the management of the hypersensitivities with particular reference to bronchial asthma, Ann. Allergy 8: 786-798, 1950. MedlineGoogle Scholar26. KennedyParePumpStanford BJJAKKRL: The effect of adrenocorticotropic hormone (ACTH) on beryllium granulomatosis: a preliminary report, Canad. M. A. J. 62: 426-428 (May) 1950. MedlineGoogle Scholar27. DobsonWeaverLewis RLJCL: Pulmonary berylliosis complicated by tuberculosis; report of a case treated by ACTH. To be published. Google Scholar28. DuToitBauer CHWa. : The effect of ACTH on ulcerative colitis, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 459-468. b. DuToit, C. H.: The treatment of chronic idiopathic ulcerative colitis with adrenocorticotropic hormone, Program 42nd annual meeting, Am. Soc. Clin. Investigation, May 1, 1950, pp. 19-20 (advance abstract). Google Scholar29. DearingBrown WHPW: Experiences with cortisone and ACTH in chronic ulcerative colitis, Proc. Staff Meet., Mayo Clin. 25: 486-488 (Aug. 16) 1950. MedlineGoogle Scholar30. ElkintonHuntGodfreyMcCroryRogersonStokes JRADLWAJa. : Effects of ACTH in patients with collagen and allied diseases, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 429-436. b. Ragan, C.: The effect of adrenocorticotropic hormone (ACTH) (Armour) on the clinical syndrome of dermatomyositis, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 423-428. c. Oppel, T. W., Coker, C., and Milhorat, A. T.: Effect of pituitary adrenocorticotrophin (ACTH) on dermatomyositis, Ann. Int. Med. 32: 318-324, 1950. Google Scholar31. ThornForshamFrawleyHillRocheStaehelinWilson GWPHTFSRMDDL: The clinical usefulness of ACTH and cortisone, New England J. Med. 242: 824-832, 1950. CrossrefMedlineGoogle Scholar32. WolfsonCohn WQC: The role of the pituitary adrenocorticotropic hormone (ACTH) and of adrenal cortical steroid hormones in the pathological physiology and experimental therapeutics of clinical gout, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 241-283. Google Scholar33. KuzellSchaffarzich WCRW: Cortisone acetate in thirty-two cases: preliminary clinical observations, Stanford M. Bull. 8: 125-132 (Aug.) 1950. MedlineGoogle Scholar34. Friedlander RD: Cortisone as an adjunct in the therapy of acute gout, J. A. M. A. 145: 11-14 (Jan. 6) 1951. CrossrefMedlineGoogle Scholar35. McQuarrieZieglerBauerWright IMREGWSa. : Studies on spontaneous hypoglycemosis: the place of pituitary adrenocorticotropic hormone (ACTH) in therapy, Am. J. Dis. Child. 80: 861-862 (Nov.) 1950 (in Soc. Proc.). b. McQuarrie, I., Bauer, E. G., Ziegler, M. R., and Wright, W. S.: The metabolic and clinical effects of pituitary adrenocorticotropic hormone in spontaneous hypoglycemosis, Mote, Proceedings of First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 225-240. Google Scholar36. CombesCanizares FCOa. : Pemphigus vulgaris: a clinicopathological study of one hundred cases, Arch. Dermat. and Syph. 62: 786-802 (Dec.) 1950. b. Cannon, A. B., Hopkins, J. B., Andrews, G. C., Calfer, H. F., Gross, P., and Nelson, C. T.: Pituitary adrenocorticotropic hormone (ACTH) and cortisone in diseases of the skin. I. Pemphigus vulgaris and other bullous dermatoses, J. A. M. A. 145: 201-206, 1951. CrossrefGoogle Scholar37. OgryzloGraham MAW: Reiter's syndrome: effect of pituitary adrenocorticotropic hormone (ACTH) and cortisone, J. A. M. A. 144: 1239-1243 (Dec. 9) 1950. CrossrefMedlineGoogle Scholar38. HenchSlocumbPolleyKendall PSCHHFEC: Effect of cortisone and pituitary adrenocorticotropic hormone (ACTH) on rheumatic diseases, J. A. M. A. 144: 1327-1335 (Dec. 16) 1950. CrossrefMedlineGoogle Scholar39. BaylesStoutStillmanLever TBCFJSW: Treatment of scleroderma with adrenocorticotropic hormone: preliminary observations, Edited by J. R. Mote, Proceedings of First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, p 447. Google Scholar40. KinsellMargen LWS: Evaluation of the clinical and metabolic effects of mixtures of testosterone propionate—estradiol benzoate. To be published. Google Scholar41. GatonReidRobey WDC: Toxemia of pregnancy, Proceedings of the Second Clinical ACTH Conference, The Blakiston Company, Philadelphia. In press. Google Scholar42. Wintrobe MM: (Editorial) ACTH and cortisone in hemopoietic disorders, Am. J. Med. 9: 715-717 (Dec.) 1950. CrossrefMedlineGoogle Scholar43. FarberShwachmanTochDowningKennedyHyde SHRVBHJa. : The effect of ACTH in acute leukemia in childhood, Proceedings of First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 328-330. b. Spies, T. D., Garcia Lopez, G., Milanes, F., Lopez Toca, R., Reboredo, A., and Aramburu, M.: A note on the effect of pituitary adrenocorticotropic hormone (ACTH) and cortisone in ameliorating the symptoms of leukemia and of cortisone in Hodgkin's disease, South. M. J., 43: 497-502 (June) 1950. c. Spies, T. D., Stone, R. E., Garcia Lopez, G., Milanes, F., Lopez Toca, R., and Reboredo, A.: Response to adrenocorticotropic hormone and cortisone in persons with carcinoma, leukemia and lymphosarcoma, Lancet 2: 241-244 (Aug. 12) 1950. d. Stickney, J. M., Heck, F. J., and Watkins, C. H.: Cortisone and ACTH in the management of leukemia and lymphoblastoma, Proc. Staff Meet., Mayo Clin. 25: 488-489 (Aug. 16) 1950. e. Burchenal, J.: Cortisone in leukemia, Blood 5: 792, 1950 (in Soc. Proc.). f. Schulman, I.: The treatment of leukemia with ACTH and cortisone, Am. J. Dis. Child. 80: 521-522, 1950 (in Soc. Proc.). Google Scholar44. PearsonElielRawson OHLPRWa. : Regression of lymphoid tumors in man induced by ACTH and cortisone, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 318-326. b. Eliel, L. P., Pearson, O. H., and White, F. C.: The comparative metabolic effects of ACTH, cortisone acetate, and "Compound F" acetate in a patient with chronic lymphatic leukemia, Program 42nd annual meeting Am. Soc. Clin. Investigation, May 1, 1950, p. 21 (advance abstract). c. Kinsell, L. W., Rogers, H., Baker, C., and Jenkins, B. J.: Monocytic leukemia treated with pituitary adrenocorticotropic hormone (ACTH), J. A. M. A. 144: 617-618, 1950. d. Donohue, W. L., Snelling, C. H., Jackson, S. H., Laski, B., and Darte, J. M.: The treatment of the leukemias and lymphomas of children with pituitary adrenocorticotropic hormone (ACTH) and 11-dehydro-17-hydroxy corticosterone (cortisone), Abstract of paper presented at the ACTH Adrenocortical Steroid Conference of the American Cancer Society, Oct. 28-29, 1950. e. Schulman, I.: ACTH and cortisone treatment of leukemia in childhood, Abstract of paper presented at the ACTH Adrenocortical Steroid Conference of the American Cancer Society, Oct. 28-29, 1950. f. Pearson, O. H., Eliel, L. P., and Talbot, T. R.: Use of ACTH and cortisone in neoplastic disease, Bull. New York Acad. Med. 26: 235, 1950. Google Scholar45. Bethell FHa. : Effect of ACTH and cortisone on plasmocytic myeloma and hypersplenic syndromes, Abstract of paper presented at the ACTH Adrenocortical Steroid Conference of the American Cancer Society, Oct. 28-29, 1950. b. Stefanini, M., Roy, C. A., Zannos, L., and Dameshek, W.: Therapeutic effect of pituitary adrenocorticotropic hormone (ACTH) in a case of Henoch-Schonlein vascular (anaphylactoid) purpura, J. A. M. A. 144: 1372, 1950. Google Scholar46. Gardner FH: Quoted by Thorn et al.14 Google Scholar47. CaldwellAdamsAndersonDick ALJWJFAA: Agranulocytosis treated with cortisone, Canad. M. A. J. 62: 506-507 (May) 1950. MedlineGoogle Scholar48. ThornForshamFrawleyHillRocheStaehelinWilson GPHTFSRMDDLa. : The clinical usefulness of ACTH and cortisone, New England J. Med. 242: 865-572, 1950. b. Flink, E. B., and Williams, C. F.: The treatment of chronic liver diseases with pituitary adrenocorticotropic hormone (ACTH), J. Lab. and Clin. Med. 36: 822 (Nov.) 1950 (in Soc. Proc.). c. Hanger, F. M., and Collins, G. L.: The effect of cortisone on chronic inflammatory diseases of the liver, Tr. A. Am. Physicians 63: 272-280, 1950. CrossrefMedlineGoogle Scholar49. BrunstingSlocumbDidcoct LACHJWa. : Effects of cortisone on acute disseminated lupus erythematosus, Proc. Staff Meet., Mayo Clin. 25: 479-482 (Aug. 16) 1950. b. Soffer, L. J., Levitt, M. F., and Baehr, G.: Use of cortisone and adrenocorticotropic hormone in acute disseminated lupus erythematosus, Arch. Int. Med. 86: 558-573 (Oct.) 1950. c. Carey, R. A., Harvey, A. M., and Howard, J. E.: The effect of adrenocorticotropic hormone (ACTH) and cortisone on the course of disseminated lupus erythematosus and periarteritis nodosa, Bull. Johns Hopkins Hosp. 87: 425-460 (Nov.) 1950. MedlineGoogle Scholar50. FloodLimarzi FTLR: Bone marrow studies in lupus erythematosus before and after ACTH and cortisone therapy, J. Lab. and Clin. Med. 36: 823 (Nov.) 1950 (in Soc. Proc.). Google Scholar51. BaggenstossShickPolley AHRMHF: The effect of cortisone on the lesions of periarteritis nodosa, Am. J. Path. 26: 709, 1950. Google Scholar52. O'LearyMontgomeryBrunstingKierland PAHLARR: Psoriasis: treatment with cortisone and ACTH, Arch. Dermat. and Syph. 62: 607, 1950. Google Scholar53. KeithPowerDaugherty NMMHGWa. : The action of cortisone in nephritis with edema, Proc. Staff Meet., Mayo Clin. 25: 491, 1950. b. Thorn, G. W., Merrill, J. P., Smith, S., III, Roche, M., and Frawley, T. F.: Clinical studies with ACTH and cortisone in renal disease, Arch. Int. Med. 86: 319, 1950. c. Burnett, C. H., Greer, M. A., Burrows, B. R., Sisson, J. H., Relman, A. S., Weinstein, L. A., and Colburn, C. G.: The effects of cortisone on the course of acute glomerulonephritis: report of a case, New England J. Med. 243: 1028, 1950. MedlineGoogle Scholar54. Farnsworth EBa. : Studies on the influence of adrenocorticotropin in acute nephritis, in simple nephrosis and in nephrosis with azotemia, Proceedings of First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. b. Barnett, H. L., McNamara, H., McCrory, W., Forman, C, Rapoport, M., Michie, A., and Barbero, G.: The effects of ACTH and cortisone on the nephrotic syndrome, Am. J. Dis. Child. 80: 519, 1950 (in Soc. Proc.). c. Filey, C. M.: The effect of adrenocorticotropic hormone (ACTH) on salt and water excretion in children with nephrotic syndrome, Am. J. Dis. Child. 80: 520, 1950 (in Soc. Proc.). d. Spector, S., and Matthews, L. W.: Effect of pituitary adrenocorticotropic hormone (ACTH) in children with nephrosis, Am. J. Dis. Child. 80: 886, 1950 (in Soc. Proc.). e. Keith, N. M., Power, M. H., Daugherty, G. W., and Keith, H. M.: Some effects of cortisone on the metabolic disturbance associated with glomerulonephritis with edema, J. Lab. and Clin. Med. 36: 843, 1950 (in Soc. Proc.). f. Luetscher, J. A., Jr., and Deming, Q. B.: Treatment of nephrosis with cortisone, J. Clin. Investigation 29: 1576, 1950. Google Scholar55. MassellWarrenSturgis BFJEGPa. : Observations on the effects of ACTH in patients with rheumatic fever and rheumatic carditis, Proceedings of First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. b. Massell, B. F., Warren, J. E., Sturgis, G. P., Hall, B., and Craige, E.: The clinical response of rheumatic fever and acute carditis to ACTH, New England J. Med. 242: 641, 1950. c. Massell, B. F., Warren, J. E., Sturgis, G. P., Hall, B., and Craige, E.: The clinical response of rheumatic fever and acute carditis to ACTH, New England J. Med. 242: 692, 1950. d. Barnes, A. R.: Effects of cortisone and ACTH in 14 patients with acute rheumatic fever, Proc. Staff Meet., Mayo Clin. 25: 478, 1950. Google Scholar56. VidebaekAsboe-HansonAstrup AGPa. : Effects of ACTH and cortisone in rheumatic fever, Ugesk. f. laeger. 113: 919, 1950 (abstr. J. A. M. A. 144: 1133, 1950). b. Massell, B. F., and Warren, J. E.: Effect of pituitary adrenocorticotropic hormone (ACTH) on rheumatic fever and rheumatic carditis, J. A. M. A. 144: 1335, 1950. c. Rosenblum, H.: Cortisone in rheumatic fever, Bull. Univ. of California Med. Center 11: 7, 1950. d. Dorfman, A., Bergenstal, D. M., Benditt, E. P., and Moses, F. E.: Effect of pituitary adrenocorticotropic hormone (ACTH) on rheumatic fever, Am. J. Dis. Child. 80: 885, 1950 (in Soc. Proc.). e. Harris, T. N., Abrams, W. B., Leo, T. F. P., and Hubbard, J. P.: Preliminary observations on the effects of cortisone in the treatment of acute rheumatic carditis, Am. J. Dis. Child. 80: 884, 1950 (in Soc. Proc.). f. Wilson, M. G., and Helper, H. N.: Effect of pituitary adrenocorticotropic hormone (ACTH) in acute rheumatic carditis, J. A. M. A. 145: 133, 1951. Google Scholar57. PereraFlemingPinesCrymble GATCKLM: Cortisone in hypertensive vascular disease, Program 42nd Annual Meeting, Am. Soc. Clin. Inv., May 1, 1950, p. 49 (advance abstract). CrossrefGoogle Scholar58. Bing Ma. : Growth-inhibiting properties of steroids, Brit. M. J. 1: 846, 1950 (in correspondence). b. Hertz, S.: Modifying effect of steroid hormone therapy of human neoplastic disease as judged by radioactive phosphorus (sic) (P32) studies, Program 42nd annual meeting, Am. Soc. Clin. Inv., May 1, 1950, p. 31 (advance abstract). c. Spies, T. D., Garcia Lopez, G., Milanes, F., Lopez Toca, R., Reboredo, A., and Aramburu, M.: A note on the effect of pituitary adrenocorticotropic hormone (ACTH) and cortisone in ameliorating the symptoms of leukemia and of cortisone in Hodgkin's disease, South. M. J. 43: 497, 1950. d. Spies, T. D., Stone, R. E., Garcia Lopez, G., Milanes, F., Lopez Toca, R., and Reboredo, A.: Response to adrenocorticotropic hormone and cortisone in persons with carcinoma, leukaemia, and lymphosarcoma, Lancet 2: 241, 1950. e. Carruthers, C.: ACTH and cortisone in animal tumors, Abstract of paper presented at the ACTH Adrenocortical Steroid Conference of the American Cancer Society, Oct. 28-29, 1950. f. de Ropp, R. S.: Some new plant-growth inhibitors, Science 112: 500, 1950. g. Schoenbach, E. G.: Antineoplastic action of ACTH and cortisone, Abstract of paper presented at the ACTH Adrenocortical Steroid Conference of the American Cancer Society, Oct. 28-29, 1950. h. Pearson, O. H., and Eliel, L. P.: Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias, J. A. M. A. 144: 1349, 1950. CrossrefGoogle Scholar59. MillikanEaton CHLMa. : Cortisone in neurologic diseases, Proc. Staff Meet., Mayo Clin. 25: 499, 1950. b. Klein, R., and Livingston, S.: The effect of adrenocorticotropic hormone in epilepsy, J. Pediat. 37: 733, 1950. c. McEachern, D.: Diseases and disorders of muscle function, Bull. New York Acad. Med. 27: 3, 1951. MedlineGoogle Scholar60. HoeferGlaser PFGHa. : Effects of pituitary adrenocorticotropic hormone (ACTH) therapy: electro-encephalographic and neuropsychiatric changes in fifteen patients, J. A. M. A. 143: 620, 1950. b. Rome, H. P., and Braceland, F. J.: Use of cortisone and ACTH in certain diseases: psychiatric aspects, Proc. Staff Meet., Mayo Clin. 25: 495, 1950. CrossrefMedlineGoogle Scholar61. TurnerHollander TBDH: Cortisone in experimental syphilis (a preliminary note), Bull. Johns Hopkins Hosp. 87: 505, 1950. MedlineGoogle Scholar62. ReissRiggsThornForsham RSDSGWPHa. : The adrenal thyroid relationship, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. b. Hardy, J. D., Riegel, C., and Erisman, E. P.: Experience with protein bound iodine (PBI); the effect of ACTH and cortisone on thyroid function, Am. J. M. Sc. 220: 290, 1950. c. Salassa, R. M.: Effects of cortisone and ACTH in certain endocrine conditions, Proc. Staff Meet., Mayo Clin. 25: 497, 1950. Google Scholar63. FreemanFershingWangSmith SJCCLCa. : The effect of ACTH on patients with pulmonary tuberculosis, Proceedings of the First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia. b. Tompsett, R., LeMaistre, C., Muschenheim, C., and McDermott, W.: Effect of ACTH on tuberculosis in humans, Program 42nd Annual Meeting, Am. Soc. Clin. Investigation, May 1, 1950, p. 59 (advance abstract). c. Hart, P. D'A., and Rees, R. J. W.: Enhancing effect of cortisone on tuberculosis in the mouse, Lancet 2: 391, 1950. d. Spain, D. M., and Molomut, N.: Effects of cortisone on the development of tuberculous lesions in guinea pigs and on their modification by streptomycin therapy, Am. Rev. Tuberc. 62: 337, 1950. e. Long, J. B., and Favour, C. B.: The ability of ACTH and cortisone to alter delayed type bacterial hypersensitivity, Bull. Johns Hopkins Hosp. 87: 186, 1950. f. Derbes, V. J., Dent, J. H., Weaver, N. K., and Vaughan, D. D.: Response of tuberculin skin test to ACTH and cortisone in tuberculous guinea pigs, Proc. Soc. Exper. Biol. and Med. 75: 423, 1950. g. Sheldon, W. H., Cummings, M. M., and Evans, L. D.: Failure of ACTH or cortisone to suppress tuberculin skin reactions in tuberculous guinea pigs, Proc. Soc. Exper. Biol. and Med. 75: 616, 1950. h. Committee on Medical Research of the American Trudeau Society: ATS warns on ACTH and cortisone effect on tuberculosis; urges tests, Nat. Tuberc. A. Bull. 37: 4 (Jan.) 1951. i. Michael, M., Jr., Cummings, M. M., and Bloom, W. L.: Course of experimental tuberculosis in the albino rat as influenced by cortisone, Proc. Soc. Exper. Biol. and Med. 75: 613, 1950. j. Leading article: Cortisone and ACTH in tuberculosis, Lancet 2: 632, 1950. Google Scholar64. HabifHareGlaser DVCCGHa. : Perforated duodenal ulcer associated with pituitary adrenocorticotropic hormone (ACTH) therapy, J. A. M. A. 144: 996, 1950. b. Sandweiss, D. J., Saltzsterin, H. C., Scheinberg, S. R., and Parks, A.: Hormone studies in peptic ulecr: pituitary adrenocorticotropic hormone (ACTH) and cortisone, J. A. M. A. 144: 1436, 1950. c. Beck, J. C., Browne, J. S. L., Johnson, L. G., Kennedy, B. J., and MacKenzie, D. W.: Occurrence of peritonitis during ACTH administration, Canad. M. A. J. 62: 423, 1950. d. Smyth, G. A.: Activation of peptic ulcer during pituitary adrenocorticotropic hormone therapy, report of three cases, J. A. M. A. 145: 474, 1951. CrossrefMedlineGoogle Scholar65. AronsonDouglasLewis NHSJM: Cortisone in Sydenham's chorea, report of two cases, J. A. M. A. 145: 30, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oakland, California*Morning Lecture, presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 11, 1951.From the Institute for Metabolic Research, Highland Alameda County Hospital, Oakland, California.Any original work here reported represents the combined work of the author and his co-workers, including Lenore Boling, M.D., Sheldon Margen, M.D., George D. Michaels, Ph.D., and John W. Partridge, M.D., aided by the following technical assistants: Carl T. Anderson, Nancy C. Dawson, E. Rosalie Greer, Eleanor E. Kipp, Judith M. Lange, Gerald Liebert, Nancy J. McKillican, Florence Olson and Sadie Smyrl.Grateful acknowledgment is made to Dr. Edward Henderson, Medical Director of Schering Corporation, for supplies of testosterone propionate; to Dr. John Mote, Assistant General Manager of the Armour Laboratories, for supplies of ACTH; to Dr. Augustus Gibson, Executive Director of the Medical Division of Merck & Company, for supplies of cortisone; and to Dr. Warren Cox, Director of Research of the Mead Johnson Research Laboratories, for supplies of Lonalac which have been used in some of the studies here reported. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe management of tuberculous meningitis.Subacute and Chronic Granulomatous ThyroiditisCorticosteroids as an adjuvant to the chemotherapy of tuberculous meningitisMorbus ReiterPrednisone for Treatment of Subacute ThyroiditisSUBACUTE GRANULOMATOUS THYROIDITIS: A REVIEW*FRANZ U. STEINBERG, M.D., F.A.C.P.Studies on Detoxification MechanismsÜber die zusätzliche Glucocorticoid-Verabreichung bei der Behandlung tuberkulöser Lungenprozesse und scröser ErgüsseSubacute Thyroiditis Treated with SalicylateCURRENT CONCEPTS IN THE MANAGEMENT OF OSTEOPOROSISExperimenteller Beitrag zur Cortisonwirkung am Tier nach Inoculation pathogener und apathogener MikroorganismenCORTICOTROPIN AND ADRENAL STEROIDS AS ADJUNCTS TO THE TREATMENT OF TUBERCULOUS MENINGITIS*J. RICHARD JOHNSON, M.D., NANCY E. FURSTENBERG, M.D., ROY PATTERSON, M.D., HENRY K. SCHOCH, M.D., WINTHROP N. DAVEY, M.D.Intrathecal hydrocortisone in the treatment of tuberculous meningitisCortisone-antimicrobial therapy in tuberculosisRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.CORTISONE VERSUS X-RAY IN THE TREATMENT OF SUBACUTE THYROIDITIS: A REPORT OF FOUR CASES*LAWRENCE TAYLOR, M.D.The Effects of Cortisone and Adrenocorticotrophc Hormone (Acth) on Pitressin Lesions of the Rabbit's StomachThe Discriminate Use of the Cortisones and Corticotropins in General Medicine with Special Reference to the Collagen DiseasesTREATMENT OF A PATIENT WITH LUPUS ERYTHEMATOSUS AND PULMONARY TUBERCULOSIS WITH ACTH, STREPTOMYCIN AND PARA-AMINOSALICYLIC ACID*J. RICHARD JOHNSON, WINTHROP N. DAVEY, F.A.C.P.Subacute thyroiditisEffects of Adrenocorticotropic Hormone (ACTH) and of Cortisone on Peptic UlcerActh and Cortisone in the Treatment of Atopic DermatitisTreatment of Subacute Thyroiditis with CortisoneComparative results of the use of ACTH, cortisone, and hydrocortisone in the treatment of intractable bronchial asthma and pulmonary emphysemaCortisone and combined antibiotic therapy of acute brucellosis melitensisThe combination of ACTH-cortisone-hydrocortisone with antibiotics in the management of overwhelmingly severe infectionsAdrenal cortical steroids in the management of a case of meningococcemiaACUTE THYROIDITIS TREATED WITH CORTISONE*S. LLOYD TEITELMAN, M.D., EDWARD F. ROSENBERG, M.D., F.A.C.P.DIETARY MODIFICATION OF THE METABOLIC AND CLINICAL EFFECTS OF ACTH AND CORTISONE*LAURANCE W. KINSELL, M.D., F.A.C.P., JOHN W. PARTRIDGE, M.D., LENORE BOLING, M.D., SHELDON MARGEN, M.D.The Effect of ACTH on Gastric Secretion in Experimental Animals 1 September 1951Volume 35, Issue 3Page: 615-651KeywordsAdrenocorticotropic hormonePropionatesResearch laboratoriesSteroid hormonesTestosterone ePublished: 1 December 2008 Issue Published: 1 September 1951 PDF downloadLoading ...