[Genetic environment of CTX-M-2 in Klebsiella pneumoniae isolates from hospitalized patients in Uruguay].
2006; National Institutes of Health; Volume: 38; Issue: 2 Linguagem: Inglês
Autores
Rafael Vignoli, Nereida Cordeiro, Verónica Seija, Felipé Schelotto, Marcela Rádice, Juan A. Ayala, P.P. Power, Gabriel Gutkind,
Tópico(s)vaccines and immunoinformatics approaches
ResumoWe studied two CTX-M-2-producing Klebsiella pneumoniae clinical strains, K96005 and K13, isolated from hospitalized patients in Uruguay, during 1996 and 2003, respectively. The genomic surroundings of bla(CTX-M-2) were characterized by PCR-mapping and DNA sequencing. Our results show that blaCTX-M-2 is included in a complex class-1 integron (InK13), associated with an orf513 in both isolates. The genetic array of the integron, aac(6')-lb, bla(OxA,2), orfD (gene cassette region), associated with an orf513-bla(CTX-M-2), seems to be widely disseminated over the Rio de la Plata region.
Referência(s)