New Triterpenoid N ‐Acetylglycosides with Molluscicidal Activity from Tetrapleura tetraptera T AUB
1989; Wiley; Volume: 72; Issue: 4 Linguagem: Inglês
10.1002/hlca.19890720407
ISSN1522-2675
AutoresMarc Maillard, Kurt Hostettmann, Clement Oladapo Adewunmi,
Tópico(s)Phytochemistry and Biological Activities
ResumoAbstract Activity‐guided fractionation of the MeOH extract of the fruits of Tetrapleura tetraptera TAUB. (Mimosaceae) afforded 4 saponins 1 – 4 , which exhibited strong molluscicidal properties against the schistosomiasis‐transmitting snails Biomphalaria glabrata. Chemical, enzymatic, and spectral methods (DCI‐MS, 1 H‐NMR, 13 C‐NMR) showed that they were N ‐acetylglycosides of oleanolic acid and of echinocystic acid. Apart from saponin 1 (aridanin), previously isolated from this plant, glycosides 2 – 4 are new naturally occurring compounds.
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