The nature and identification of quantitative trait loci: a community's view
2003; Nature Portfolio; Volume: 4; Issue: 11 Linguagem: Inglês
10.1038/nrg1206
ISSN1471-0064
AutoresOduola Abiola, Joe M. Angel, Philip Avner, Alexander A. Bachmanov, John K. Belknap, Beth Bennett, Elizabeth P. Blankenhorn, David A. Blizard, Valerie J. Bolivar, Gudrun A. Brockmann, Kari J. Buck, Jean‐François Bureau, William L. Casley, Elissa J. Chesler, James M. Cheverud, Gary A. Churchill, Melloni N. Cook, John C. Crabbe, Wim E. Crusio, Ariel Darvasi, Gerald de Haan, Peter Démant, R. W. Doerge, Rosemary W. Elliott, Charles R. Farber, Lorraine Flaherty, Jonathan Flint, Howard K. Gershenfeld, John P. Gibson, Jing Gu, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui Chen Hsu, Kent W. Hunter, Fuad A. Iraqi, Ritsert C. Jansen, Thomas E. Johnson, Byron C. Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F. Manly, Douglas B. Matthews, Juan F. Medrano, Margarete Mehrabian, Guy Mittleman, Beverly A. Mock, Jeffrey S. Mogil, Xavier Montagutelli, Grant Morahan, John D. Mountz, Hiroki Nagase, Richard S. Nowakowski, Bruce F. O’Hara, А. В. Осадчук, Beverly Paigen, Abraham A. Palmer, Jeremy L. Peirce, Daniel Pomp, Michael Rosemann, Glenn D. Rosen, Leonard C. Schalkwyk, Ze’ev Seltzer, Stephen H. Settle, Kazuhiro Shimomura, Siming Shou, James M. Sikela, Linda D. Siracusa, Jimmy L. Spearow, Cory Teuscher, David W. Threadgill, Linda A Toth, Ayo A. Toye, Csaba Vadász, Gary Van Zant, Edward K. Wakeland, Robert W. Williams, Huang Ge Zhang, Fei Zou,
Tópico(s)Gene expression and cancer classification
ResumoThis white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?
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