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Acute Lymphoblastic Leukemia in Infants: 20 years of Experience

2013; Elsevier BV; Volume: 89; Issue: 1 Linguagem: Inglês

10.1016/j.jped.2013.02.010

1678-4782

Amanda Ibagy, Denise Brentan Silva, Jackline Seiben, Ana P.F.F. Winneshoffer, Tatiana El Jaick Bonifácio Costa, Juliana Shmitz Dacoregio, Imaruí Costa, Daniel Faraco,

Neonatal Respiratory Health Research

To analyze patients younger than 2 years with acute lymphoblastic leukemia, treated in the period between 1990 and 2010 in a state reference center.This was a clinical-epidemiological, cross-sectional, observational, and descriptive study. It included patients younger than 2 years with acute lymphoblastic leukemia, treated in the period of 1990 to 2010 in a pediatric oncology unit of a state reference center, totaling 41 cases.All patients were white ethnicity, and 60.9% were females. Regarding age, 24.38% were younger than 6 months, 17.07% were between 6 months and 1 year, and 58.53% were older than 1 year. The age of 6 months was statistically significant for the outcome of death. Predominant signs and symptoms were fever, bruising, and petechiae. A leukocyte count > 100,000 was found in 34.14% of cases, hemoglobin count < 11 in 95.13%, and platelet count < 100,000 in 75.61. Infiltration of central nervous system was present in 12.91% of patients. According to the lineage, B-cell lineage predominated (73%), but the T-cell line was statistically significant for death. 39% of patients had disease recurrence. In relation to vital status, 70.73% of the patients died; septic shock was the main cause.Acute lymphoblastic leukemia in infants has a high mortality rate, especially in children under 1 year and those with T-cell derived lineage.