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The Fine Structure of the Melanocyte and Melanin Granule**From the Division of Dermatology, (Dr. F. W. Lynch, Director) and the Department of Anatomy, University of Minnesota Medical School, Minneapolis 14, Minnesota.Aided by research grants M-388 and B-782 from the National Institute of Mental Health and the National Institute for Neurologic Diseases and Blindness, U. S. Public Health Service, and by the Graduate Medical Research Fund of the University of Minnesota.

1961; Elsevier BV; Volume: 36; Issue: 1 Linguagem: Inglês

10.1038/jid.1961.7

1523-1747

Alvin S. Zelickson, John F. Hartmann,

Erythrocyte Function and Pathophysiology

In 1951, Pease (1) in one of the first studies of human skin with the electron microscope, was able to identify clear cells with short dendritic processes. He commented on the pigment granules which he described as oblong and uniform in size and density. Laden et al (2), in 1953, reported on the basal cell and the epidermal-dermal junction. They noted abundant pigment granules in the basal layer. These they described as dense, oval and uniform in shape, forming at times a nuclear cap. Selby (3), in 1955, reported a study of the dermo-epidermal junction and the basal cell layer. She, too, noted the pigment granules and described them as oblong bodies which were too dense to reveal an internal structure. She was unable, however, to identify the “clear cells” of light microscopy and felt that these might be artifacts.