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Regional Differences in the Effects of Glutamate Uptake Inhibitor l-Trans-Pyrrolidine-2,4-Dicarboxylic Acid on Extracellular Amino Acids and Dopamine in Rat Brain

1998; Elsevier BV; Volume: 31; Issue: 3 Linguagem: Inglês

10.1016/s0306-3623(98)00047-0

1879-0011

Jun’ichi Semba, Maki Wakuta,

Molecular Sensors and Ion Detection

The effects of the glutamate transporter inhibitor, trans-PDC, on extracellular amino acids, were investigated in the frontal cortex, striatum, hippocampus and cerebellum of rats using in vivo microdialysis. Trans-PDC infusion (0.1, 1, 10 mM) dose-dependently increased Glu and Asp levels, and these increases in the cerebellum were smaller than those in other brain regions. A small but significant dose-dependent increase was observed for Gly and Tau. However, high extracellular Glu induced by trans-PDC was not sufficient to increase extracellular DA in the striatum and frontal cortex.