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Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats

2013; Wiley; Volume: 30; Issue: 1 Linguagem: Inglês

10.1002/tox.21891

ISSN

1522-7278

Autores

Manar Hamed Arafa, Dalia Abd-Elmoain Mohamed, Hebatallah Husseini Atteia,

Tópico(s)

Carcinogens and Genotoxicity Assessment

Resumo

Environmental ToxicologyVolume 30, Issue 1 p. 26-43 Research Article Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats Manar Hamed Arafa, Manar Hamed Arafa Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Government, EgyptSearch for more papers by this authorDalia AbdElmoain Mohamed, Dalia AbdElmoain Mohamed Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Government, EgyptSearch for more papers by this authorHebatallah Husseini Atteia, Corresponding Author Hebatallah Husseini Atteia Department of Biochemistry, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Sharkia Government, EgyptCorrespondence to: Hebatallah Husseini Mohamed Atteia; e-mail: [email protected]Search for more papers by this author Manar Hamed Arafa, Manar Hamed Arafa Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Government, EgyptSearch for more papers by this authorDalia AbdElmoain Mohamed, Dalia AbdElmoain Mohamed Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Government, EgyptSearch for more papers by this authorHebatallah Husseini Atteia, Corresponding Author Hebatallah Husseini Atteia Department of Biochemistry, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Sharkia Government, EgyptCorrespondence to: Hebatallah Husseini Mohamed Atteia; e-mail: [email protected]Search for more papers by this author First published: 31 July 2013 https://doi.org/10.1002/tox.21891Citations: 23Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat ABSTRACT Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-CYP on lung tissues. For this purpose, thirty two male rats were divided into four different groups (eight rats for each). Group (I) gavaged with corn oil (control group), group (II) gavaged daily with NAC (150 mg kg−1 body weight), group (III) gavaged with α-CYP (14.5 mg kg−1 body weight/day, dissolved in corn oil), group (IV) gavaged with NAC then with α-CYP 2 h later for 12 weeks. α-CYP significantly increased serum lactate dehydrogenase (LDH) and pulmonary malondialdehyde (MDA) levels, while decreased the activities of catalase (CAT) and superoxide dismutase (SOD) as well as reduced glutathione (GSH) content in lung. It also provoked higher levels of serum nitric oxide (NO), lung interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), hydroxyproline (Hyp) as well as heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-КB) gene expression in lung tissues. Histopathological alterations in lung with congestion, cellular infiltration, necrotic changes and thickening of inter-alveolar septa were observed following α-CYP administration. 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