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HLA-G Is Differentially Expressed in Thyroid Tissues

2013; Mary Ann Liebert, Inc.; Volume: 24; Issue: 3 Linguagem: Inglês

10.1089/thy.2013.0246

1557-9077

Nathalie Lobo de Figueiredo Feitosa, Janaina Cristina de Oliveira Crispim, Bruna Riedo Zanetti, Patrícia Künzle Ribeiro Magalhães, Christiane Pienna Soares, Edson García Soares, Luciano Neder, Eduardo Antônio Donadi, Léa Maria Zanini Maciel,

Cervical Cancer and HPV Research

HLA-G is a nonclassical major histocompatibility complex molecule that has well-recognized immunomodulatory properties. The expression of HLA-G in tumor cells has been considered to be detrimental, permitting tumor spreading and decreased survival. We evaluated the expression of HLA-G in histologically normal thyroid tissue, goiter, and benign and malignant thyroid tumors, and studied the relationship between HLA-G expression and patient clinical variables.The immunohistochemistry expression of HLA-G was performed on 72 specimens of papillary thyroid carcinoma (PTC), 19 follicular thyroid carcinomas (FTC), 22 follicular adenomas (FA), 22 colloid goiters (CG), and 14 histologically normal thyroid glands (NT). The percentage of HLA-G staining was graded from absent (-) to intense (+++).HLA-G was faintly expressed in areas of hyperplasia in NT and CG. In PTC, FTC, and FA, the percentage of cell staining was significantly higher than in NT and CG (p 1 cm exhibited increased HLA-G staining when compared to smaller tumors (p=0.03). Aggressive histologic subtypes of PTC have a higher median stained tumor area. No association was found between HLA-G expression and tumoral staging or patient disease-free survival.The gradual increase of HLA-G expression from hyperplasia to carcinomas, and the association of strong HLA staining with some variables implicated in poor prognosis corroborate the unfavorable role of HLA-G in tumor thyroid cells, inhibiting cytotoxic immune system cells and facilitating tumor evasion and progression.