Produção Nacional
Revisado por pares
The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability
2003; National Academy of Sciences; Volume: 100; Issue: 20 Linguagem: Inglês
10.1073/pnas.1832124100
ISSN1091-6490
AutoresAna Tereza Ribeiro de Vasconcelos, Darcy F. de Almeida, Mariangela Hungría, C. T. Guimarães, Regina Vasconcellos Antônio, Francisca C. Almeida, Luiz Gonzaga Paula de Almeida, Rosana de Almeida, José Alves-Gomes, Elizabeth M. Mazoni Andrade, Júlia R. Araripe, Magnólia Fernandes Florêncio de Araújo, Spartaco Astolfi‐Filho, Vasco Azevedo, Alessandra J Baptista, Luiz Artur Mendes Bataus, Jacqueline da Silva Batista, André Beló, Cássio van den Berg, Maurı́cio Reis Bogo, Sandro L. Bonatto, Juliano Bordignon, Marcelo M. Brígido, Cristiana A. Alves Brito, Marcelo Brocchi, Hélio Almeida Burity, Anamaria A. Camargo, Divina das Dôres de Paula Cardoso, Newton Portilho Carneiro, Dirce Maria Carraro, Cláudia Carvalho, Júlio Cézar de Mattos Cascardo, Benildo Sousa Cavada, Ligia Maria Oliveira Chueire, Tânia Beatriz Creczynski‐Pasa, Nivaldo C. Costa Da Cunha-Junior, Nelson J. R. Fagundes, Clarissa Lima Falão, Fabiana Fantinatti‐Garboggini, Izeni Pires Farias, Maria Sueli Soares Felipe, Lílian Pereira Ferrari, Jesus Aparecido Ferro, Maria Inês Tiraboschi Ferro, Glória Regina Franco, Nara Suzy Aguiar de Freitas, Luiz Roberto Furlan, Ricardo T. Gazzinelli, E. A. Gomes, Pablo Rodrigues Gonçalves, Thalles B. Grangeiro, Dário Grattapaglia, Edmundo C. Grisard, Ebert Seixas Hanna, S. N. Jardim, Jomar Pereira Laurino, Lélia Cristina Tenório Leoi, Lucymara Fassarella Agnez‐Lima, Maria de Fátima Loureiro, Maria do Carmo Catanho Pereira de Lyra, Humberto Maciel França Madeira, Gilson P. Manfio, Andréa Queiróz Maranhão, Wellington S. Martins, Sônia Marli Zingaretti, Sílvia Regina Batistuzzo de Medeiros, Rosely de Vasconcellos Meissner, María Manuela Martins, Fabrícia F. Nascimento, Marisa Fabiana Nicolás, Jaquelline Germano de Oliveira, Sérgio C. Oliveira, Maria Paula Paixão, Juliana Alves Parente, Fábio de Oliveira Pedrosa, Sergio Danilo Junho Penat, José Odair Pereira, Maristela Pereira, Luciana Santos Rodrigues Costa Pinto, Luciano Da SilvaPinto, Jorge Ivan Rebelo Porto, Deise Porto Potrich, Cicero Eduardo Ramalho-Neto, Alessandra Maria Moreira Reis, Liu Um Rigo, Edson Rondinelli, Elen Bethleen Pedraça do Santos, Fabrício R. Santos, Maria Paula Cruz Schneider, Héctor N. Seuánez, A.M.R. Silva, Artur Silva, Denise Maria Wanderlei Silva, Rosane Silva, Isabella de Carmo Simões, Daniel Simon, Célia Maria de Almeida Soares, Renata de Bastos Ascenço Soares,
Tópico(s)Biochemical and Structural Characterization
ResumoChromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals ( i ) extensive alternative pathways for energy generation, ( ii ) ≈500 ORFs for transport-related proteins, ( iii ) complex and extensive systems for stress adaptation and motility, and ( iv ) widespread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications.
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