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Erythropoietin down‐regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans

2010; Wiley; Volume: 589; Issue: 6 Linguagem: Inglês

10.1113/jphysiol.2010.194241

1469-7793

Niels Vidiendal Olsen, Niels‐Jacob Aachmann‐Andersen, Peter Oturai, Thor Munch‐Andersen, Andreas Bornø, Carl J. Hulston, Niels‐Henrik Holstein‐Rathlou, Paul Robach, Carsten Lundby,

Acute Kidney Injury Research

Non‐technical summary Recombinant human erythropoietin (rHuEPO) decreases circulating levels of renin and aldosterone, two hormones regulating water and salt homeostasis, but the effect of rHuEPO on renal function is unknown. This study demonstrates that rHuEPO reduces the reabsorption of water and sodium in the proximal renal tubules and, probably by activation of the tubuloglomerular feedback mechanism, also causes a fall in glomerular filtration rate. Thus, the decrease in plasma concentrations of renin and aldosterone may be secondary to increased end‐proximal tubular delivery of water and sodium. In conclusion, the fall in proximal reabsorption together with a reduced filtered load and a decrease in angiotensin II and aldosterone‐dependent tubular reabsorption are expected to increase the oxygen tension in the renal tissue. This may serve to down‐regulate the endogenous renal synthesis of EPO in the presence of high levels of circulating rHuEPO.