Antitumor activity of basic fibroblast growth factor-saporin mitotoxin in vitro and in vivo.
1992; National Institutes of Health; Volume: 52; Issue: 1 Linguagem: Inglês
Autores
Julie Beitz, P. Davol, Jeffrey W. Clark, Jun Kato, Miguel Ángel Medina, A. Raymond Frackelton, Douglas A. Lappi, Andrew Baird, Paolo Calabresi,
Tópico(s)Transgenic Plants and Applications
ResumoMany cancer cell lines express basic fibroblast growth factor (FGF) receptors, making them potential targets for the delivery of FGF-based cytotoxic compounds. To this end, we have investigated the antitumor activity of a novel mitotoxin, Fibroblast Growth Factor-saporin (FGF-SAP), a conjugate of FGF and the ribosome-inactivating protein, saporin. In vitro, FGF-SAP is cytotoxic for human melanoma, teratocarcinoma, and neuroblastoma cells expressing FGF-receptors. Mice treated with FGF-SAP i.v., on a variety of schedules, showed dramatic tumor growth inhibition with minimal toxicity. Thus, FGF-SAP appears to be a well-tolerated and potent antitumor agent. The potential of FGF-targeted cytotoxicity is discussed.
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