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Experimental Ecthyma Contagiosum (ORF)1

1956; Elsevier BV; Volume: 26; Issue: 4 Linguagem: Inglês

10.1038/jid.1956.39

1523-1747

Clayton E. Wheeler, Michael Potter, Edward P. Cawley,

Toxin Mechanisms and Immunotoxins

Ecthyma contagiosum (Orf, scabby mouth, contagious pustular dermatitis) is a virus infection of sheep and goats which is occasionally transmitted to man. Observation of an 18 year old girl (21) with the disorder aroused our interest in the virus and prompted the study of some of its properties. The purpose of this communication is to report the results of a series of experimental inoculations of the virus of ecthyma contagiosum into a number of different animal species. The order of the report will include (A) review of the literature pertaining to experimental ecthyma contagiosum (B) materials and methods (C) experimental disease in sheep (D) experimental disease in rabbits (E) negative inoculation experiments in mice, guinea pigs and the chorioallantoic membrane of the developing chick embryo (F) discussion and (G) conclusions.