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Action of 1-β-d-Arabinofuranosylcytosine on mammalian tumor cells—1.

1972; Pergamon Press; Volume: 8; Issue: 4 Linguagem: Inglês

10.1016/0014-2964(72)90122-3

1879-2995

Rudolf K. Ζahn, Wernér E.G. Müller, Wolf Forster, Armin Maidhof, Rudolf Beyer,

HIV/AIDS drug development and treatment

Abstract Synchronized mouse lymphoma cells were treated with ara-C- 3 H at the beginning of the S-phase with twice the ED 50 concentration. In DNA isolated from these cells ara-C could be traced. It could be shown that the radioactivity in nucleotide-and nucleoside fractions obtained after enzymic digestion of ara-C-DNA was due for more than 87% to ara-C- 3 H. The radioactivity of ara-C- 3 H can be almost quantitatively attributed to cytosine and arabinose. An incorporation of ara-C into RNA could not be detected.