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PENICILLIN TREATMENT OF EMPYEMA: REPORT OF 24 CASES AND REVIEW OF THE LITERATURE

1946; American College of Physicians; Volume: 24; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-24-3-343

1539-3704

Bernadette Brown, Edwin M. Ory,

Pharmaceutical studies and practices

Article1 March 1946PENICILLIN TREATMENT OF EMPYEMA: REPORT OF 24 CASES AND REVIEW OF THE LITERATUREBRUCE BROWN, M.D., EDWIN M. ORY, M.D., MANSON MEADS, M.D., MAXWELL FINLAND, M.D., F.A.C.P.BRUCE BROWN, M.D.Search for more papers by this author, EDWIN M. ORY, M.D.Search for more papers by this author, MANSON MEADS, M.D.Search for more papers by this author, MAXWELL FINLAND, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-3-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally conceded that the sulfonamide drugs have not been successful in effecting cures in cases of empyema once frank pus has developed in the pleural cavity. The most that can be expected from these drugs is a reduction in the incidence of empyema when they are properly used in the treatment of pneumonia, a reduction in mortality in operated cases and possibly the cure without open drainage of an occasional empyema that is treated very early.1-10Certain properties of penicillin as a therapeutic agent suggest that it should be more useful than the sulfonamides in cases of empyema....Bibliography1. HURWITZSTEPHENS SHB: Empyema in children, Jr. Pediat., 1939, xiv, 11. CrossrefGoogle Scholar2. THOMPSONEDWARDSHOAGLAND LDJCCL: Experiences in the treatment of lobar pneumonia, Ann. Int. Med., 1940, xiii, 1138. Google Scholar3. NEUHOFTOUROFF HAS: Acute putrid abscess of the lung; surgical treatment and results in 86 consecutive cases, Jr. Thoracic Surg., 1940, ix, 439. CrossrefGoogle Scholar4. KEEFERRANTZRAMMELKAMP CSLACH: Hemolytic streptococcal pneumonia and empyema; study of 55 cases with special reference to treatment, Ann. Int. Med., 1941, xiv, 1533. Google Scholar5. POWERS GF: Chemotherapy in the treatment of streptococcus empyema in children, Internat. Clin., 1941, ii, 132. Google Scholar6. FINLANDSTRAUSSPETERSON MEOL: Sulfadiazine: therapeutic evaluation and toxic effects on 446 patients, Jr. Am. Med. Assoc., 1941, cvi, 2641. CrossrefGoogle Scholar7. LAMMONDIMMLER THCL: Management of acute empyema in children, Am. Jr. Surg., 1941, liv, 29. Google Scholar8. SHANK PA: Empyema of the lung; a review of the literature and an analysis of 169 cases, Am. Jr. Surg., 1944, lxvi, 224. CrossrefGoogle Scholar9. ENTIN MA: Treatment of early empyema by intrapleural injection of penicillin with report of seven cases, McGill Med. Jr., 1944, xii, 421. Google Scholar10. APPLEBAUM IL: Complications of staphylococcus sepsis; treatment by intrapleural and intrapericardiac injections of sulfa compounds, Mil. Surg., 1945, xcvi, 424. Google Scholar11. ANDERSON DG: The treatment of infections with penicillin, New England Jr. Med., 1945, ccxxxii, 400 and 423. CrossrefGoogle Scholar12. HERRELL WE: Penicillin and other antibiotic agents, 1945, W. B. Saunders Co., Philadelphia. Google Scholar13. FLOREYHEATLEY MENG: Systemic administration of penicillin by absorption from body cavities, Lancet, 1945, i, 748. CrossrefGoogle Scholar14. ORYMEADSBROWNWILCOXFINLAND EMMBCM: Penicillin levels in serum and in some body fluids during systemic and local therapy, Jr. Lab. and Clin. Med., 1945, xxx, 809. Google Scholar15. ABRAHAMFLOREYCHAINFLETCHERGARDNERHEATLEYJENNINGS EPHWECMADNGMA: Further observations on penicillin, Lancet, 1941, ii, 177. CrossrefGoogle Scholar16. ABRAHAMCHAIN EPE: An enzyme from bacteria able to destroy penicillin, Nature, 1940, cxlvi, 837. CrossrefGoogle Scholar17. WOODRUFFFOSTER HBJW: Microbiological aspects of penicillin. VII. Bacterial penicillinase, Jr. Bact., 1945, xlix, 7. CrossrefGoogle Scholar18. RAMMELKAMP CH: A method of determining the concentration of penicillin in body fluids and exudates, Proc. Soc. Exper. Biol. and Med., 1942, li, 95. CrossrefGoogle Scholar19. RAMMELKAMPMAXON CHT: Resistance of Staphylococcus aureus to the action of penicillin, Proc. Soc. Exper. Biol. and Med., 1942, li, 386. CrossrefGoogle Scholar20a. GARDNER AD: Morphological effects of penicillin on bacteria, Nature, 1940, cxlvi, 837. b. GARDNER, A. D.: Microscopical effect of penicillin on spores and vegetative cells of bacilli, Lancet, 1945, i, 658. CrossrefGoogle Scholar21. KEEFERBLAKEMARSHALLLOCKWOODWOOD CSFGEKJSWB: Penicillin in the treatment of infections: a report of 500 cases, Jr. Am. Med. Assoc., 1943, cxxii, 1217. CrossrefGoogle Scholar22. LYONS C: Penicillin therapy of surgical infections in the U. S. Army. A report, Jr. Am. Med. Assoc., 1943, cxxiii, 1007. CrossrefGoogle Scholar23. BENNETTPARKES TIT: Penicillin in sulphonamide-resistant pneumonias with special reference to staphylococcal infection and empyema, Lancet, 1944, i, 305. CrossrefGoogle Scholar24. TILLETTCAMBIERMCCORMACK WSMJJE: The use of penicillin in the local treatment of pneumococcal empyema, Jr. Clin. Invest., 1945, xxiv, 595. CrossrefGoogle Scholar25. DAWSONHOBBY MHGL: The clinical use of penicillin. Observations in 100 cases, Jr. Am. Med. Assoc., 1944, cxxiv, 611. CrossrefGoogle Scholar26. FLYNN SE: Penicillin in treatment of empyema following lobar pneumonia, U. S. Nav. Med. Bull., 1944, xliii, 353. Google Scholar27. BUTLERPERRYVALENTINE ECKMFC: Treatment of acute empyema with penicillin, Brit. Med. Jr., 1944, ii, 171. CrossrefGoogle Scholar28. LOCKWOODWHITEMURPHY JSWLFD: The use of penicillin in surgical infections, Ann. Surg., 1944, cxx, 311. CrossrefGoogle Scholar29. STAINSBYFOSSDRUMHELLER WNHLJF: Clinical experiences with penicillin, Pennsylvania Med. Jr., 1944, xlviii, 119. Google Scholar30. KENTSAGER EMWW: Current practice in treatment of thoracic empyema, Surg. Clin. North Am., 1944, xxiv, 1492. Google Scholar31. ROBERTSTUBBSBATES JEOSM: Pleural and pulmonary suppuration treated with penicillin, Lancet, 1945, i, 39. CrossrefGoogle Scholar32. FOX HJ: Penicillin program at the United States Naval Hospital in Portsmouth, Va., War Med., 1945, vii, 170. Google Scholar33. BLADESHAMILTONDUGAN BJEDJ: Observations on the treatment of empyema thoracis with penicillin, Surgery, 1945, xvii, 572. Google Scholar34. COLLENSELLERS MFAL: Penicillin therapy in pneumococcic pneumonia, Permanente Foundation Med. Bull., 1945, iii, 49. Google Scholar35. SPINKHALL WWWH: Penicillin therapy at the University of Minnesota Hospitals: 1942-1944, Ann. Int. Med., 1945, xxii, 510. Google Scholar36. KRAMER LI: Report of case of empyema treated with penicillin, Rhode Island Med. Jr., 1945, xxviii, 425. Google Scholar37. HEALYKATZ MJHL: The treatment of empyema thoracis with penicillin, Jr. Am. Med. Assoc., 1945, cxxviii, 568. CrossrefGoogle Scholar38. RUDENSKYSPRONGWOODS HDHCC: The medical treatment of acute empyema; report of 5 cases cured with chemotherapy and thoracentesis, Jr. Am. Med. Assoc., 1945, cxxviii, 573. CrossrefGoogle Scholar39. HIRSHFELDBUGGSABBOTTPILLING JWCWWEMA: The value of penicillin in the treatment of empyema, Jr. Am. Med. Assoc., 1945, cxxviii, 577. CrossrefGoogle Scholar40. FARQUHARSONGREEYTOWNSEND RFPSR: Results of penicillin therapy. A report for the Joint Services Penicillin Committee, Canad. Med. Assoc. Jr., 1945, liii, 1. Google Scholar41. KULLMANCRELLIN HJJA: Penicillin in suppurative disease of the lungs due to Streptococcus hemolyticus , Ann. Int. Med., 1945, xxiii, 135. Google Scholar42. POPPE JK: The limitations of penicillin in treating empyema, Jr. Am. Med. Assoc., 1945, cxxix, 434. Google Scholar43. D'ABREULITCHFIELDHODSON ALJWCJ: Major complications of penetrating wounds of the chest, Lancet, 1944, ii, 197. CrossrefGoogle Scholar44. NICHOLSONSTEVENSON WFCR: Intrapleural penicillin in penetrating wounds of the chest, Brit. Jr. Surg., 1944, xxxii, 176. CrossrefGoogle Scholar45. WHITE WL: Use of penicillin in prevention of postoperative empyema following lung resection. Report of a controlled study, Jr. Am. Med. Assoc., 1944, cxxvi, 1016. CrossrefGoogle Scholar46. COLLISDAVISONSMITH JLMHPS: Management of traumatic pyothorax, Lancet, 1945, i, 778. CrossrefGoogle Scholar47. BURFORDBLADES THB: Influence of sulfonamide therapy in postpneumonic empyema thoracis, Jr. Am. Med. Assoc., 1942, cxviii, 950. CrossrefGoogle Scholar48. NEUHOFHIRSHFELD HS: Putrid empyema; ruptured putrid abscess of lung, Ann. Surg., 1934, c, 1105. CrossrefGoogle Scholar49. WOOD CB: Pyopneumothorax occurring as a complication of acute pulmonary suppuration, Am. Jr. Surg., 1935, xxx, 289. CrossrefGoogle Scholar50. MAIERGRACE HCEJ: Putrid empyema, Surg., Gynec., and Obst., 1942, lxxiv, 69. Google Scholar51. TILLETTCAMBIERMCCORMACK WSMJJE: The treatment of lobar pneumonia and pneumococcal empyema with penicillin, Bull. New York Acad. Med., 1944, xx, 142. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication November 26, 1945.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital and the Department of Medicine, Harvard Medical School, Boston, Massachusetts.With the technical assistance of Clare Wilcox. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Treatment of Pleural Effusion Complicating PneumoniaNecrotizing Pneumonitis and Empyema Due to Microaerophilic StreptococciPOSTGRADUATE CONTINUATION COURSE Fitzsimons Army Hospital and University of Colorado School of MedicinePneumococcal PneumoniaPleurisy and Empyema 1 March 1946Volume 24, Issue 3Page: 343-370KeywordsDrugsHospital medicineMedical servicesMortalityPenicillinPneumoniaResearch laboratoriesSulfonamide ePublished: 1 December 2008 Issue Published: 1 March 1946 Copyright & PermissionsCopyright, 1946, by The American College of PhysiciansPDF downloadLoading ...