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EXPERIMENTAL STUDIES ON HEPARIN AND ITS INFLUENCE ON TOXICITY OF DIGITALOIDS, CONGO RED, COBRA VENOM AND OTHER DRUGS

1943; American College of Physicians; Volume: 18; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-18-5-772

1539-3704

David I. Macht,

Heparin-Induced Thrombocytopenia and Thrombosis

Article1 May 1943EXPERIMENTAL STUDIES ON HEPARIN AND ITS INFLUENCE ON TOXICITY OF DIGITALOIDS, CONGO RED, COBRA VENOM AND OTHER DRUGSDAVID I. MACHT, M.D., F.A.C.P.DAVID I. MACHT, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-5-772 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONAt first engaging the attention primarily of physiologists and hematologists, the study1, 2, 3of heparin was soon taken up also by biochemists, who of recent years have succeeded largely in unraveling its complicated chemical structure. More recently, heparin has acquired a practical significance through the work of clinical investigators who discerned its potentialities as a therapeutic agent. Indeed, Howell and McDonald4had suggested such clinical applications of heparin, but its actual value in medical practice was not demonstrated until the painstaking investigations of American, Canadian and Swedish scientists were well under way. It is far beyond the scope...Bibliography1. MCLEAN J: The thromboplastic action of cephalin, Am. Jr. Physiol., 1916, xli, 250-257. CrossrefGoogle Scholar2. HOWELL WH: The coagulation of blood, Harvey Lectures, 1916-1917 volume, Series XII, 272-323. Google Scholar3. HOWELLHOLT WHE: Two new factors in blood coagulation, heparin and thrombosis, Am. Jr. Physiol., 1918, xlvii, 328-341. CrossrefGoogle Scholar4. HOWELLMCDONALD WHCH: Note on effect of repeated intravascular injections of heparin, Bull. Johns Hopkins Hosp., 1930, xlvi, 365-368. Google Scholar5. JORPES JE: Heparin, its chemistry, physiology and application in medicine, 1939, Oxford University Press, London. Google Scholar6. MASON MF: Heparin: review of its history, chemistry, physiology and clinical applications, Surgery, 1939, v, 451 and 618. Google Scholar7. CRAFOORD C: Preliminary report on post-operative treatment with heparin as preventive of thrombosis, Acta chir. Scandinav., 1937, lxxix, 407-426. Google Scholar8. CRAFOORD C: Heparin and post-operative thrombosis, Acta chir. Scandinav., 1939, lxxxii, 319-333. Google Scholar9. MURRAYJAQUESPERRETTBEST DWLBTSCH: Heparin and vascular occlusion, Canad. Med. Assoc. Jr., 1936, xxxv, 621-622. Google Scholar10. MURRAYJAQUESPERRETTBEST DWLBTSCH: Heparin and thrombosis of veins following injury, Surgery, 1937, ii, 163-187. Google Scholar11. SOLANDTBEST DYCH: Heparin and coronary thrombosis in experimental animals, Lancet, 1938, ii, 130-132. CrossrefGoogle Scholar12. CRAFOORD C: Heparin as prophylactic against postoperative thrombosis, Acta med. Scandinav., 1941, cvii, 116-122. Google Scholar13. CRAFOORDJORPES CJE: Heparin as prophylactic against thrombosis, Jr. Am. Med. Assoc., 1941, cxvi, 2831-2835. CrossrefGoogle Scholar14. BEST CH: Heparin and thrombosis, Harvey Lecture, Bull. New York Acad. Med., 1941, xvii, 796-817. Google Scholar15. LEISSNER H: Use of heparin in obstetric practice as means of preventing thrombosis, Acta med. Scandinav., 1941, cvii, 127-130. Google Scholar16. CLASON S: Three cases of pulmonary embolism following confinement treated with heparin, Acta med. Scandinav., 1941, cvii, 131-135. Google Scholar17. PLOMAN KG: Heparin treatment of thrombosis in central vein of retina, Acta ophth., 1938, xvi, 502-512. Google Scholar18. HOLMINPLOMAN NKG: Thrombosis of central vein of retina treated with heparin, Lancet, 1938, i, 664-665. CrossrefGoogle Scholar19. BOSTRÖMWILLIAM-OLSSON CGL: Thrombosis of central vein of retina successfully treated with heparin; second case, Lancet, 1938, ii, 78-79. CrossrefGoogle Scholar20. FERGUSON RR: Thrombosis of interior temporal branch of right retinal vein successfully treated with heparin, Jr. Am. Med. Assoc., 1941, cxvii, 1351-1352. CrossrefGoogle Scholar21. KELSON SR: New method of treatment of subacute bacterial endocarditis using sulfapyridine and heparin in combination; preliminary report, Jr. Am. Med. Assoc., 1939, cxiii, 1700-1702. Google Scholar22. LEACH CE: Chemotherapy and heparin in subacute bacterial endocarditis; further experiences, Jr. Am. Med. Assoc., 1941, cxvii, 1345-1350. CrossrefGoogle Scholar23. CHARLESSCOTT AFDA: Studies on heparin; preparation of heparin, Jr. Biol. Chem., 1933, cii, 425-429. CrossrefGoogle Scholar24. BERGSTRÖMJORPESWILANDER SEO: Studies on pure heparin, Scandinav. Arch. f. Physiol., 1937, lxxvi, 175-185. CrossrefGoogle Scholar25. CHARGAFF E: Studies on chemistry of blood coagulation; protamines and blood clotting, Jr. Biol. Chem., 1938, cxxv, 671-676. CrossrefGoogle Scholar26. HOLMGRENWILANDER HO: Beitrag zur Kenntnis der Chemie und Funktion der Ehrlichschen Mastzellen, Ztschr. f. mikr. anat. Forsch., 1937, xlii, 242-278. Google Scholar27. MACHT DI: Influence of barometric changes on potency of digitalis for cats, Am. Jr. Physiol., 1931, xcvii, 540. Google Scholar28. ABELMACHT JJDI: Two crystalline pharmacological agents obtained from the tropical toad, Bufo agua, Jr. Pharmacol. and Exper. Therap., 1912, iii, 319-377. Google Scholar29. RUDOLPH C: Various uses of congo red in diagnosis, prognosis and therapy, Med. Jr. and Rec., 1933, cxxxvii, 296-297. Google Scholar30. BELONOSCHKINWÖHLISCH BE: Über die angebliche Neubildung von Fibrinogen durch Kongorot, Klin. Wchnschr., 1933, xii, 1371-1372. CrossrefGoogle Scholar31. BECKER J: Blutstillung durch Kongorot; vorläufige Mitteilung, München. med. Wchnschr., 1930, lxxvii, 396-397. Google Scholar32. GREEN WL: Congo red in treatment of certain infections; preliminary report, Jr. Indiana Med. Assoc., 1937, xxx, 527-529. Google Scholar33. MACHTHARDENGRUMBEIN DIWCML: Toxicological studies on congo red, Jr. Am. Pharm. Assoc., 1939, xxviii, 495-498. Google Scholar34. TALIAFERROHAAG IHB: Toxicity and effect of congo red on blood coagulation, Am. Jr. Med. Sci., 1937, cxciii, 626-633. CrossrefGoogle Scholar35. RICHARDSON AP: Congo red: hematologic reactions, Am. Jr. Med. Sci., 1939, cxcviii, 87-97. CrossrefGoogle Scholar36. MACHT DI: Experimental and clinical study of cobra venom as an analgesic, Proc. Nat. Acad. Sci., 1936, xxii, 61-71. CrossrefGoogle Scholar37. MACHT DI: Therapeutic experiences with cobra venom, ANN. INT. MED., 1938, xi, 1824-1833. Google Scholar38. MACHT DI: Recent developments in the pharmacology and therapeutics of cobra venom, Med. Rec., 1941, cliii, 369-375 and 379. Google Scholar39. MICHEELBODE FG: Zur Kenntnis der Schlangengifte, Ber. d. deutsch. chem. Gesellsch., 1938, lxxi, 1302. CrossrefGoogle Scholar40. KYESSTRAUSER PER: Heparin inhibition of anaphylactic shock, Jr. Immunol., 1926, xii, 419-422. Google Scholar41. WILLIAMSVAN DE CARR OBFR: Effect of heparin on anaphylactic shock in guinea pigs, Proc. Soc. Exper. Biol. and Med., 1927, xxiv, 798-800. CrossrefGoogle Scholar42. MACHTDUNNINGSTICKEL DIFAE: Influence of heparin injections on anaphylactic shock, Am. Jr. Physiol., 1928, lxxxv, 390. Google Scholar43. HANZLIKBUTTSTOCKTON PJEMAB: Reciprocal action of crop muscles in anaphylactic shock with note on effects of heparin, Jr. Immunol., 1927, xiii, 409-425. Google Scholar44. REEDLAMSON CIRW: Influence of heparin on course of anaphylaxis in guinea pig, Jr. Immunol., 1927, xiii, 433-438. Google Scholar45. WILANDER O: Complete blood analysis of heparinized blood, Acta med. Scandinav., 1938, xciv, 258-266. Google Scholar46. JAQUESWATERS LBET: Identity and origin of anticoagulant of anaphylactic shock in dog, Jr. Physiol., 1941, xcix, 454-466. CrossrefGoogle Scholar47. ROCHA E SILVADRAGSTEDT MCA: Liberation of heparin by trypsin, Proc. Soc. Exper. Biol. and Med., 1941, xlviii, 152-155. Google Scholar48. DRAGSTEDTWELLSROCHA E SILVA CAJAM: Heparin as an antidote to trypsin in the rat, Fed. Proc., 1942, i, 149. Google Scholar49. KIRCHHEIM L: Untersuchungen über Trypsinvergiftung, Arch. f. exper. Path. u. Pharmakol., 1913, lxxiv, 374-398. CrossrefGoogle Scholar50. ERSHLERBLAISDELL ILIH: Massive hematuria following use of heparin in cavernous thrombosis, Jr. Am. Med. Assoc., 1941, cxvii, 927-930. CrossrefGoogle Scholar51. COPLEYLALICH ALJJ: The experimental production of a hemophilia-like condition in heparinized mice, Am. Jr. Physiol., 1942, cxxxv, 547-556. CrossrefGoogle Scholar52. Bleeding from mucous membranes caused by heparin, etc., Jr. Am. Med. Assoc., Queries and Minor Notes, 1942, cxviii, 1526. Google Scholar53. The Chemical Dicoumarin, Science, 1942, Supplement xcv, 12-13. Google Scholar54. MACHTMORA DICF: Effect of opium alkaloids on the behavior of rats in the circular maze, Jr. Pharmacol, and Exper. Therap., 1920, xvi, 219-235. Google Scholar55. MACHTBRYAN DIHF: Influence des venins de serpent sur le comportement du rat dans un labyrinthe circulaire, Compt.-rend. Soc. de biol., 1935, cxix, 306-309. Google Scholar56. MACHT DI: Contributions to phytopharmacology or the applications of plant physiology to medical problems, Science, 1930, lxxi, 302-306. CrossrefGoogle Scholar57. MACHTGRUMBEIN DIML: Influence of indole acetic, indole butyric and naphthalene acetic acids on roots of Lupinus albus seedlings, Am. Jr. Bot., 1937, xxiv, 457-460. CrossrefGoogle Scholar58. MACHT DI: The phytotoxic reactions of normal and pathological blood sera, Protoplasma, 1937, xxvii, 1-8. CrossrefGoogle Scholar59. MACHTMACHT DIMB: Phytotoxic reactions of some blood sera, Jr. Lab. and Clin. Med., 1941, xxvi, 597-615. Google Scholar60. MORRISONSAMWICK MAA: Intramedullary (sternal) transfusion of human bone marrow; preliminary report, Jr. Am. Med. Assoc., 1940, cxv, 1708-1711. CrossrefGoogle Scholar61. TOCANTINS LM: Rapid absorption of substances injected into bone marrow, Proc. Soc. Exper. Biol. and Med., 1940, xlv, 292-296. CrossrefGoogle Scholar62. TOCANTINSO'NEILL LMJF: Infusion of blood and other fluids into circulation via bone marrow, Proc. Soc. Exper. Biol. and Med., 1940, xlv, 782-783. CrossrefGoogle Scholar63. MACHT DI: The absorption of drugs and poisons through the skin and mucous membranes, Jr. Am. Med. Assoc., 1938, cx, 409-413. CrossrefGoogle Scholar64. MACHT DI: Absorption of drugs through the bone marrow, Proc. Soc. Exper. Biol. and Med., 1941, xlvii, 292-302. Google Scholar65. MYLONHOFFKATZENSTEINWINTERNITZ EHRMC: The fall in blood pressure associated with intravenous injection of tissue extracts, Science, 1941, xciv, 190-191. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication December 22, 1942.Read before the Section on Pathology and Physiology of the American Medical Association at Atlantic City, June 11, 1942.†Director, Pharmacological Research Laboratory, Hynson, Westcott & Dunning, Inc., Baltimore, Maryland. 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