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Cytogenetic studies of human T-cell leukemia virus type I carriers

1990; Elsevier BV; Volume: 49; Issue: 2 Linguagem: Inglês

10.1016/0165-4608(90)90137-y

1873-4456

Takahiro Itoyama, Naoki Sadamori, Seiji Tokunaga, I. Sasagawa, Hideo Nakamura, Ei-ichi Yao, Tohru Jubashi, Yasuaki Yamada, Shuichi Ikeda, Michito Ichimaru,

Animal Disease Management and Epidemiology

Recently, the chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL), and this anomaly has also been confirmed in the preleukemic state of adult T-cell leukemia (pre-ATL) patients. Because the cytogenetic abnormality at the stage of human T-cell leukemia virus type I (HTLV-I) carrier remains uncertain, we performed cytogenetic studies of lymphocytes stimulated with phytohemagglutinin in three HTLV-I carriers and three non-HTLV-I carriers in an ATL family. As a result, in three HTLV-I carriers, four of 311 cells examined (1.3%) had chromosome 14q11 anomaly. However, in three non-HTLV-I carriers, none of 260 cells examined had chromosome 14q11 anomaly. These results suggest that chromosome 14q11 anomaly is already present at the stage of HTLV-I carrier and seems to be an important cytogenetic clue to the pathogenesis of ATL.