Portal de Periódicos da CAPES

Nutrient–gene interactions determine mitochondrial function: effect of dietary fat

1998; Wiley; Volume: 12; Issue: 2 Linguagem: Inglês

10.1096/fasebj.12.2.243

1530-6860

Moon‐Jeong Chang Kim, Carolyn D. Berdanier,

Adipose Tissue and Metabolism

The effect on mitochondrial respiration of feeding hydrogenated coconut oil, corn oil, or menhaden oil (MO) to diabetes-prone BHE/cdb rats and normal Sprague Dawley (SD) rats was studied. Both fat source and strain affected the temperature dependence of succinate-supported respiration. The transition temperature was greater in BHE/cdb rats than in the SD rats. The efficiency of ATP synthesis as reflected by the ADP:O ratio was decreased in the BHE/cdb rats compared to SD rats, with the exception of the comparison made at 37°C with the MO-fed rats; at this temperature, the ADP:O ratios were similar. The diet and strain differences suggest a dietary lipid–gene interaction with respect to the mobility of subunit 6 of the F1F0ATPase. This subunit has two errors in its gene: one that affects the proton channel and another that likely affects its mobility within the inner mitochondrial membrane.— Kim, M.-J. C., Berdanier, C. D. Nutrient–gene interactions determine mitochondrial function: effect of dietary fat. FASEB J. 12, 243–248 (1998)