Portal de Periódicos da CAPES

Toxic Granulocytopenia, Purpura Hemorrhagica and Aplastic Anemia Following the Arsphenamines

1932; American College of Physicians; Volume: 5; Issue: 10 Linguagem: Inglês

10.7326/0003-4819-5-10-1238

1539-3704

ADOLPH B. LOVEMAN,

Plant-based Medicinal Research

Article1 April 1932Toxic Granulocytopenia, Purpura Hemorrhagica and Aplastic Anemia Following the ArsphenaminesADOLPH B. LOVEMAN, A.B., M.D.ADOLPH B. LOVEMAN, A.B., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-10-1238 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSenator77 in 1888 reported four fatal cases of acute infectious pharyngitis. Unfortunately no bacteriological or hematological studies were made. Fourteen years later Brown70 reported the first case of acute infectious pharyngitis with complete blood studies. The patient showed a marked leukopenia and on one occasion the polymorphonuclears were reduced to one per cent. From then until Schultz75 reported his cases of agranulocytic angina, examples of an agranulocytic blood picture were described by Schwartz,73 Türk,72 and Marchand.74As early as 1920, Moore and Foley7reported agranulocytic blood pictures following the arsphenamines. Since then many cases have been added to the literature....References1 ROHNERBALDRIDGEHANSMANN FJCWGH: Chronic benzene poisoning, Arch. Path. and Lab. Med., 1926, i, 221. Google Scholar2 LAWSONJACKSONCATTANACH GBWPGS: Arsenic poisoning, Jr. Am. Med. Assoc, 1925, lxxxv, 24. CrossrefGoogle Scholar3 ASKEY JM: Aplastic anemia due to benzol poisoning, Cal., and West. Med., 1928, xxix, 262. Google Scholar4 JENSEN J: Purpura hemorrhagica following neoarsphenamine, Minn. Med., 1929, xii, 689. Google Scholar5 KASTLIN GJ: Agranulocytic angina, Am. Jr. Med. Sci., 1927, clxxiii, 799. CrossrefGoogle Scholar6 O'LEARYCONNER PAHM: Acute purpura hemorrhagica as complication in treatment of syphilis, Am. Jr. Syph., 1925, ix, 262. Google Scholar7 MOOREFOLEY JEFE: Serious reactions from salvarsan and diarsenol brands of arsphenamine, unusual blood pictures, with report of a fatal case, Arch. Dermat. and Syph., 1920, i, 25. CrossrefGoogle Scholar8 SELLING L: A preliminary report of some cases of purpura hemorrhagica due to benzol poisoning, Johns Hopkins Hosp. Bull., 1910. xxi, 33. Google Scholar9 FARLEY DL: Depressed bone marrow function from arsphenamine, including type of so-called agranulocytosis, Am. Jr. Med. Sci., 1930, clxxix, 214. CrossrefGoogle Scholar10 KENNEDY WR: On occurrence of blood dyscrasia following administration of neoarsphenamine, Canad. Med. Assoc. Jr., 1928, xix, 439. Google Scholar11 DAY LW: Acute purpura hemorrhagica following administration of sulpharsphenamine with recovery, U. S. Vet. Bur. Med. Bull., 1930, vi, 62. Google Scholar12 FEINBERG SM: Aplastic anemia following neoarsphenamine, Jr. Am. Med. Assoc., 1922. lxxviii, 888. Google Scholar13 WILLCOXWEBSTER WHJ: The toxicology of salvarsan; dioxydiamido-arsenobenzol (salvarsan or kharsivan), Brit. Med. Jr., 1916, i, 473. CrossrefGoogle Scholar14 VISWANATHAN R: Case of agranulocytic angina, Indian Med. Gaz., 1930, lxv, 328. Google Scholar15 JONESPOTTER ABBP: Agranulocytic angina, Miss., Med. Assoc., 1930, xxvii, 151. Google Scholar16 LOWENBURG H: Neosalvarsan and leucocytes, New York Med. Jr., 1919, cx, 326. Google Scholar17 LERMAN J: Comparison of arsphenamine and catarrhal jaundice with special reference to blood picture, Am. Jr. Med. Sci., 1929, clxxviii, 54. CrossrefGoogle Scholar18 TALLEYGRIFFITH JEGC: Discussion of six cases of agranulocytosis, Med. Clin. North Am., 1930, xiii, 1079. Google Scholar19 COMBES FC: Purpura hemorrhagica following sulpharsphenamine; report of case, Arch. Dermat. and Syph., 1927, xv, 194. CrossrefGoogle Scholar20 FLORAND A: Purpura under arsenical treatment, (abstract) Jr. Am. Med. Assoc., 1922, lxxix, 1803. Google Scholar21 APPEL B: Granulocytic purpuric hemorrhagic reaction after neoarsphenamine, Urol. and Cutan. Rev., 1930, xxxiv, 100. Google Scholar22 PHELPSWASHBURN JRWA: Toxic effects of arsenical compounds employed in treatment of syphilis in United States Navy; statistical study of results of 272,354 injected doses of neoarsphenamine and other compounds of arsenic, Urol. and Cutan. Rev., 1930, xxxiv, 458. (Also, U. S. Nav. Med. Bull., 1930, xxviii, 659.) Google Scholar23 WEISKOTTEN HG: Action of benzol, Jr. Med. Research, 1927, xxxvii, 215. Google Scholar42 BUIST TP: Case of fatal hemorrhagic purpura following administration of sulfarsenol, Jr. Roy. Army Med. Corps, 1925, xlv, 299. Google Scholar25 RABUTOURY RP: Purpura from arsphenamine, Presse méd., 1922, xxx, 810. Google Scholar26 ANYWL-DAVIES T: Hemorrhagic purpura following therapeutic administration of neosalvarsan, Brit. Jr. Dermat., 1921, xxxiii, 264. CrossrefGoogle Scholar27 GOUGEROTBARTHÉLEMYUHRY HP: Un cas d'agranulocytose post-arsénobenzolique sans angine et sans hémorragies, Bull. Soc. Franç. de dermat. et syph., 1929, xxxvi, 590. Google Scholar28 WEILISCH-WALL PE: Un cas d' anémie grave arsénobenzolique, Bull. et mém. Soc. Méd. d. hôp. de Paris, 1927, li, 319. Google Scholar29 WIDALBERTRAND-FONTAINE F: Anémie aplastique grave associée à un syndrome purpurique et réalisant le tableau clinique d'une leucémie aiguë, survenne à la suite d' injections de novarsénobenizol, Bull. et mém. Soc. méd. d. hôp de Paris, 1926, l, 980-985. Google Scholar30 KRUMBHAAR EB: Leukemoid blood pictures in various clinical conditions, Am. Jr. Med. Sci., 1926, clxxii, 519. CrossrefGoogle Scholar31 VEDELGIRAUDGIRAUD MMMG: Anémie pernicieuse aplastique post-novarsénobenzolique, avec hemorragies, purpura et atteinte hepatique, Ann. de dermat. et syph., 1923, iv, 712. Google Scholar32 NICOLASGATÉLEBEUF JJF: Purpura aigue hémorragique post-novarsénobenzolique, Ann. de dermat. et syph., 1923, iv, 705-711. Google Scholar33 LABBÉLANGLOIS MS: Purpura hemorragique aigu par intoxication arsenicale. Bull. et mém. Soc. méd. d. hôp de Paris, 1919, xliii, 786. Google Scholar34 ESCHBACH MH: Contribution au rôle du novarsénobenzol dans les icteres chez les syphilitiques et dans les dyscrasies sanguines, Bull. et mém. Soc. méd. d. hôp de Paris, 1919, xliii, 1120. Google Scholar35 JACQUELINCÉLICELANGLOIS AJ: Sur un cas d' agranulocytose post-arsénobenzolique, Bull. et mém. Soc. méd. d. hôp de Paris, 1929, liii, 8. Google Scholar36 LAIGNEL-LAVASTINELEVYDESOILLE MRH: Un cas mortel d' anémie aplastique hemorragique par intoxication benzénique professionnelle, Bull. et. mém. Soc. méd. d. hôp de Paris, 1928, lii, 1264. Google Scholar37 FOSTER JM: Agranulocytic angina following administration of neoarsphenamine; report of case with recovery following use of sodium thiosulphate. Col. Med., 1930, xxvii, 388. Google Scholar38 REZNIKOFF P: Nucleotide therapy in agranulocytosis, Jr. Clin. Invest., 1930, ix, 381. CrossrefGoogle Scholar39 POUZIN-MALÈGUE M: A propos d' un cas d'agranulocytose post-arsénobenzolique, Bull. et mém. Soc. méd. d. hôp de Paris, 1928, lii, 1786. Google Scholar40 SMITH CM: Severe bleeding and purpura following administration of neoarsphenamine, Arch. Dermat. and Syph., 1925, xi, 237. CrossrefGoogle Scholar41 DODDWILKINSON KSJ: Severe granulocytic aplasia of bone marrow; report of a case following arsphenamine treatment in congenital syphilis. Jr. Am. Med. Assoc., 1928, xc, 663. CrossrefGoogle Scholar42 WHEELIHAN RY: Granulocytic aplasia of bone marrow following use of arsenic, Am. Jr. Dis. Child., 1928, xxxv, 1032. Google Scholar43 LEREDDE E: Sur quelques accidents bénins, graves et mortels dus à l' arsénobenzol, Rev. gén. de clin. et de thérap., 1919, xxxiii, 33. Google Scholar44 AUBERTIN C: Purpura, anémie aplastique hémorragique et agranulocytose post arsénobenzoliques, Monde méd., 1926, xxxvi, 885. Google Scholar45 GIBSON AG: Action of adrenalin in aplastic anemia, Lancet, 1926, ii, 948. CrossrefGoogle Scholar46 SMITH AR: Chronic benzol poisoning among women industrial workers; study of women exposed to benzol fumes in six factories, Jr. Indust. Hyg., 1928, x, 73. Google Scholar47 MCCORD CP: Present status of benzene (benzol) poisoning, Jr. Am. Med. Assoc., 1929, xciii, 280. CrossrefGoogle Scholar48 MCCORD CP: Industrial benzol (benzene) poisoning; presence of immature red cells in blood stream. Contributions to Med. Sci., The Aldred Scott Warthin Ann. Vol., 1927, 39. Google Scholar49 SWEENEY JS: Chronic aplastic anemia and symptomatic hemorrhagic purpura probably due to benzol poisoning; case report, Am. Jr. Med. Sci., 1928, clxxv, 317. CrossrefGoogle Scholar50 HAMILTON A: Fifteen years of industrial toxicology, Contributions to Med. Sci., The Aldred Scott Warthin Ann Vol., 1927, 231. Google Scholar51 ROHNERBALDRIDGEHANSMANN FJCWGH: Chronic benzene poisoning, Arch. Path. and Lab. Med., 1926, i, 221. Google Scholar52 MOOREKEIDEL JEA: Stomatitis and aplastic anemia due to neoarsphenamine, Arch. Dermat. and Syph., 1921, iv, 169. CrossrefGoogle Scholar53 LINDSAYRICESELINGER JWECMA: Purpura hemorrhagica following neoarsphenamine, South. Med. Jr., 1930, xxiii, 715. CrossrefGoogle Scholar54 HARKINS HN: Granulocytopenia and agranulocytic angina with recovery. Report of eight cases with four recoveries, Arch. Int. Med, 1931, xlvii, 408. CrossrefGoogle Scholar55 BALDRIDGENEEDLES CWRJ: Idiopathic neutropenia, Am. Jr. Med. Sci., 1931, clxxxi, 533. CrossrefGoogle Scholar56 MILLS ES: Idiopathic aplastic anemia or aleukia hemorrhagica, Am. Jr. Med. Sci., 1931, clxxxi, 521. Google Scholar57 DAMESHEKINGALL WM: Agranulocytosis (malignant neutropenia), Am. Jr. Med. Sci., 1931, clxxxi, 502. CrossrefGoogle Scholar58 EVANS FA: Transitional cell, Arch. Int. Med, 1916, xvii, 1. CrossrefGoogle Scholar59 WILSON CP: Marked monocytosis accompanied by neutrophilic leukopenia following antisyphilitic treatment, Am. Jr. Med Sci., 1929, clxxvii, 88. CrossrefGoogle Scholar60 CITRONHIRSCHFIELD JH: Hemorrhagic diathesis and aplastic anemia in treatment of syphilis, Med. Klin., 1925, xxi, 805. Google Scholar61 SCHULTZJACOBOURTZ WL: Agranulocytosis, Med. Klin., 1925, xxi, 1642. Google Scholar62 THILL O: Akuter Morbus Werlhof nach Myosalvarsan Behandlung, Ztschr. f. klin. Med, 1928, cix, 285. Google Scholar63 CALLOMON F: Purpura haemorrhagica mit Hämaturie and letaler Lungenblutung nach Neosalvarsan Behandlung, Dermat. Wchnschr., 1922. lxxv, 1197. Google Scholar64 UGRIUMOWIDELSOHN BJ: Ein Beitrag zur Kenntnis der aplastischen Anämie, Deutsch. Arch. f. klin. Med., 1927, clvii, 257. Google Scholar65 POGÁNY E: Fall einer Aleukie nach Salvarsan Behandlung, Ztschr. f. Hals-, Nasen- u. Ohrenh., 1927-28, xviii, 383. Google Scholar66 FISHER RL: Case of agranulocytic angina successfully treated with immuno-transfusion, Jr. Mich. Med Soc., 1930, xxix, 435. Google Scholar67 MADERNA C: Porpora emorragica post-arsenobenzolica, Riforma med., 1927, xliii, 204. Google Scholar68 LESPINNEWYDOOGHE : Purpura after arsphenamine, Ann. d. mal. vén,. 1922, xvii, 241. Google Scholar69 WEILISCH-WALL PEP: Hemorrhagic reaction to arsphenamine, Presse méd., 1925, xxxi, 657. Google Scholar70 BROWN PK: A fatal case of acute primary infectious pharyngitis with extreme leukopenia, Am. Med., 1902, iii, 649. Google Scholar71 BLUMER G: The agranulocytic blood picture in conditions other than angina, Jr. Am. Med. Assoc., 1930, clxxix, 11. Google Scholar72 TÜRK W: Septische Erkrankungen bei Verkümmerung des granulozytensystems, Wien. klin. Wchnschr, 1907, xx, 157. Google Scholar73 SCHWARTZ E: Leucopenie, Wien. klin. Wchnschr., 1904, xvii, 806. Google Scholar74 MARCHAND F: Über ungewöhnlich starke Lymphocytose im Anschluss an Infektionen, Deutsch. Arch. f. klin. Med., 1913, cx, 359. Google Scholar75 SCHULTZ W: On different throat affections, Deutsch. med. Wchnschr., 1922, xlviii, 1495. Google Scholar76 ROBERTSKRACKE SRRR: Agranulocytosis; report of case, Jr. Am. Med. Assoc., 1930, xcv, 780. CrossrefGoogle Scholar77 Taken from Brown.70. Google Scholar78 ROBERTSKRACKE RRR: Agranulocytosis: its classification, with cases and comments, Ann. Int. Med., 1931. v, 40. (Appeared after this article was submitted for publication.) LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Studies and contributions of the Department of Dermatology and Syphilology of the University of Michigan Medical School, service of Dr. Udo J. Wile.†Received for publication, July 28, 1931. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemical Agents Which Suppress Myelopoiesis: Agranulocytosis and LeukemiaToxische OsteopathienToxische OsteopathienHematologic Aspects of Arsenic IntoxicationBlutveränderungen bei Syphilis 1 April 1932Volume 5, Issue 10Page: 1238-1256KeywordsAnginaAplastic anemiaBloodDermatologyHematology and oncologyHemorrhagePharyngitis Issue Published: 1 April 1932 PDF downloadLoading ...