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Alzheimer's Disease-Related Loss of Pin1 Function Influences the Intracellular Localization and the Processing of AβPP

2012; IOS Press; Volume: 30; Issue: 2 Linguagem: Inglês

10.3233/jad-2012-111259

1875-8908

Lucia Pastorino, Suk Ling, Martin Balaštík, Pengyu Huang, Darshan Pandya, Linda K. Nicholson, Kun Ping Lu,

Biochemical and Molecular Research

Increased amyloidogenic processing of the amyloid-β protein precursor (AβPP) is a characteristic of Alzheimer's disease (AD). We previously observed that the prolyl isomerase Pin1, which is down-regulated in AD, regulates AβPP conformation accelerati