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Presence of an Atypical Serum Globulin in Localized Cutaneous Amyloidosis**From the Serviço de Dermatologia do Hospital dos Servidores do Estado, and the Instituto Oswaldo Cruz, Seçāo de Química, Rio de Janeiro, GB, Brasil.

1963; Elsevier BV; Volume: 40; Issue: 4 Linguagem: Inglês

10.1038/jid.1963.32

1523-1747

Jarbas A Porto, Humberto T. Cardoso, Ismelia A.A. Venâncio,

Autoimmune Bullous Skin Diseases

Maxwell and Kimball (1) first reported on the familial aspects of systemic amyloidosis. Andrade (2) reported a disease, “Mal dos peinhos” endemic to a region of Portugal, that tended to be familial; definite histopathological evidence of primary systemic amyloidosis was obtained in autopsies of two cases. Rukavina, Block and Curtis (3) demonstrated the presence of an abnormal serum globulin, alpha 2/-globulin, by means of free-moving boundary electrophoresis in cases of primary systemic amyloidosis, and clearly showed the familial tendency of this disease.