Clinical implementation of NIPT – technical and biological challenges
2015; Wiley; Volume: 89; Issue: 5 Linguagem: Inglês
10.1111/cge.12598
ISSN1399-0004
AutoresPaul Brady, Nathalie Brison, K Van Den Bogaert, Thomy de Ravel, Hilde Peeters, Hilde Van Esch, Koenraad Devriendt, Eric Legius, Joris Vermeesch,
Tópico(s)Parvovirus B19 Infection Studies
ResumoNon‐invasive prenatal testing ( NIPT ) for fetal aneuploidy detection is increasingly being offered in the clinical setting. Whereas the majority of tests only report fetal trisomies 21, 18 and 13, genome‐wide analyses have the potential to detect other fetal, as well as maternal, aneuploidies. In this review, we discuss the technical and clinical advantages and challenges associated with genome‐wide cell‐free fetal DNA profiling.
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