Vitamin B6 Deficiency in Rabbits
1957; Elsevier BV; Volume: 61; Issue: 1 Linguagem: Inglês
10.1093/jn/61.1.127
ISSN1541-6100
Autores Tópico(s)Pharmacological Effects of Natural Compounds
ResumoA vitamin B6 deficiency has been produced in rabbits fed a diet devoid of this factor. The symptoms were lowered growth rate; death in about 100 days; scaly skin of the ears; some acrodynia of the nose, eyes and forepaws; convulsion similar to those described for other species; mild anemia; prolonged blood clotting time; and a sudden paralytic collapse accompanied by very marked creatinuria; creatine excretion increased from normal values of about 10 mg/day/kg of body weight to over 120 mg in less than three days. Death usually occurred during this collapse. In the few animals that survived, the paralysis of the hind quarters increased to complete immobility and contractural deformities and creatine excretion returned to normal. The vitamin B6 requirement of rabbits, under these conditions, was found to be 39 μg daily, or about 1 μg/gm of diet, as measured by growth. Soft feces contained three to 4 times as much vitamin B6 as hard feces, and accounted for 54% of the total fecal vitamin B6. These ratios were approximately the same in deficient as well as normal rabbits, although the total excretion increased from 8μg/day/kg up to 59μg/day/kg.
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