Portal de Periódicos da CAPES

Detection and characterization of OXA-48-producing Klebsiella pneumoniae originated in Bulgaria

2015; Taylor & Francis; Volume: 28; Issue: 5 Linguagem: Inglês

10.1179/1973947815y.0000000047

1973-9478

Stefana Sabtcheva, Ivan Ivanov, Bozhana Todorova, Yordan Simeonov, Elina Dobreva, Krasimira Ivanova, Tzvetan Velinov, Todor Kantardjiev,

Infections and bacterial resistance

We report the identification of OXA-48-producing Klebsiella pneumoniae, causing peritonitis in a cancer patient admitted to the Oncology Hospital in Sofia. The isolate had reduced susceptibility to carbapenems but remained susceptible to extended-spectrum cephalosporins. PCR and sequencing confirmed the presence of blaOXA-48 gene flanked by two intact copies of IS1999 on truncated ΔTn1999.1. This transposon was located on unusual non-typeable 29-kb plasmid that could be transferred only by transformation. Multilocus sequence typing (MLST) indicated the presence of the sequence type ST530.This is the first documented infection due to OXA-48-producing Enterobacteriaceae strain in Bulgaria.