DIRECT AND INDIRECT ACTIONS OF LSD, SEROTONIN AND RELATED COMPOUNDS ON SEROTONIN-CONTAINING NEURONS
1973; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-078150-8.50037-2
AutoresG K Aghajanian, Henry J. Haigler,
Tópico(s)Psychedelics and Drug Studies
ResumoThis chapter discusses the direct and indirect actions of D-lysergic acid diethylamide (LSD), serotonin, and related compounds on serotonin-containing neurons. LSD given in small doses by the systemic route inhibits the firing of neurons in the midbrain raphe nuclei of rats. Evidence provided by the formaldehyde condensation method indicates that raphe neurons contain serotonin and other indoleamines. The rate of firing of raphe neurons is depressed by drugs or precursors that produce a large increase in the concentration of serotonin in brain. This occurs regardless of whether the increase in serotonin is caused by a reduction in catabolism as with monoamine oxidase inhibitors or an increase in synthesis as produced by loading doses of the initial precursor of serotonin, L-tryptophan. The intensity of histochemical fluorescence of raphe neurons is enhanced by monoamine oxidase inhibitors. Microiontophoretic studies support the view that a direct inhibitory action may account for the depression of raphe firing seen after systemic administration of this drug.
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