Chapter 4 Tumor-associated carbohydrate antigens and modified blood group antigens
1996; Elsevier BV; Linguagem: Inglês
10.1016/s0167-7306(08)60290-2
ISSN1875-7901
Autores Tópico(s)Lung Cancer Research Studies
ResumoThis chapter discusses the present knowledge of tumor-associated carbohydrate antigens (TACA's). It also discusses the pathobiological and functional significance of TACA's. A large number of monoclonal antibody (mAbs) showed distinctive reactivity with tumor cells but not with normal cells were found to be directed to carbohydrate antigens. On this basis, the classical concept of tumor-associated carbohydrate antigens (TACA's) was revived. A ganglio-series TACA, fucosyl-GM1, is accumulated in small cell lung carcinoma (SCLC). Various anti-fucosyl-GM1 mAb's have been used for detection of this antigen in SCLC. The antigen has been detected in serum of patients with SCLC, but not those with other types of lung cancer. The presence of fucosyl-GM1 may be related to the characterization of SCLC as a neuroendocrine tumor, based on the presence of neuroendocrine differentiation markers and neurosecretory granules in tumors. The only clear example of a globo-series TACA is Burkitt lymphoma antigen (BLA).
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