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Acquired factor X deficiency with associated defects in platelet aggregation

1980; Elsevier BV; Volume: 69; Issue: 1 Linguagem: Inglês

10.1016/0002-9343(80)90512-4

1555-7162

Richard A. Edgin, Earl N. Metz, John J. Fromkes, Floyd M. Beman,

Eosinophilic Disorders and Syndromes

Abstract A 79 year old white woman presented with a severe bleeding disorder. Evaluation revealed a prothrombin time of 27.6 seconds (control, 11 seconds) and an activated partial thromboplastin time of 61 seconds. Specific clotting factor assays showed an isolated deficiency of factor X ranging from 7 to 12 per cent on three determinations. Platelet aggregation and bleeding time were also abnormal in response to epinephrine and collagen. Factor X levels and platelet aggregation returned to normal and bleeding stopped after institution of corticosteroid therapy.