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Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response

2009; Wiley; Volume: 32; Issue: 1 Linguagem: Inglês

10.1111/j.1365-3024.2009.01160.x

1365-3024

Fernanda Chiuso‐Minicucci, Nelson Mendes Marra, Sofia Fernanda Gonçalves Zorzella-Pezavento, T. G. D. FRANÇA, Larissa Lumi Watanabe Ishikawa, M.R.V. Amarante, Alessandro Francisco Talamini do Amarante, Alexandrina Sartori,

Animal Nutrition and Physiology

Parasite ImmunologyVolume 32, Issue 1 p. 74-78 Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response F. CHIUSO-MINICUCCI, F. CHIUSO-MINICUCCI Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorN. M. MARRA, N. M. MARRA Department of Parasitology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilSearch for more papers by this authorS. F. G. ZORZELLA-PEZAVENTO, S. F. G. ZORZELLA-PEZAVENTO Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorT. G. D. FRANÇA, T. G. D. FRANÇA Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorL. L. W. ISHIKAWA, L. L. W. ISHIKAWA Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorM. R. V. AMARANTE, M. R. V. AMARANTE Department of Parasitology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilSearch for more papers by this authorA. F. T. AMARANTE, A. F. T. AMARANTE Department of Parasitology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilSearch for more papers by this authorA. SARTORI, A. SARTORI Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this author F. CHIUSO-MINICUCCI, F. CHIUSO-MINICUCCI Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorN. M. MARRA, N. M. MARRA Department of Parasitology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilSearch for more papers by this authorS. F. G. ZORZELLA-PEZAVENTO, S. F. G. ZORZELLA-PEZAVENTO Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorT. G. D. FRANÇA, T. G. D. FRANÇA Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorL. L. W. ISHIKAWA, L. L. W. ISHIKAWA Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this authorM. R. V. AMARANTE, M. R. V. AMARANTE Department of Parasitology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilSearch for more papers by this authorA. F. T. AMARANTE, A. F. T. AMARANTE Department of Parasitology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilSearch for more papers by this authorA. SARTORI, A. SARTORI Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil,Search for more papers by this author First published: 09 December 2009 https://doi.org/10.1111/j.1365-3024.2009.01160.xCitations: 14 Alexandrina Sartori, Departamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Distrito de Rubião Junior s/n, Botucatu, São Paulo, 18618-000, Brazil (e-mail: sartori@ibb.unesp.br). Disclosures: None Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-γ during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection. Citing Literature Volume32, Issue1January 2010Pages 74-78 RelatedInformation