Study of the nature of recognition in molecularly imprinted polymers, II
1999; Elsevier BV; Volume: 848; Issue: 1-2 Linguagem: Inglês
10.1016/s0021-9673(99)00483-5
ISSN1873-3778
AutoresHåkan S. Andersson, Jesper G. Karlsson, Sergey A. Piletsky, Ann-Christin Koch-Schmidt, Klaus Mosbach, Ian A. Nicholls,
Tópico(s)Forensic Toxicology and Drug Analysis
ResumoTo investigate the extent and nature of the monomer–template association of molecularly imprinted polymer pre-polymerisation mixtures, a series of (−)-nicotine molecularly imprinted acrylic polymers was prepared using a range of monomer–template molar ratios. Load capacity studies performed in the chromatographic mode showed an unexpected increase in retention at higher nicotine sample loads. Further analyses of this effect indicate that solvation effects, and potentially the presence of higher order template complexes, may explain this behaviour. The implications of these results are discussed in terms of the current model for molecular imprinting, and it is suggested that the possibility of template self-association should be included in this model.
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