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ADRENO-SYMPATHOGENIC HEART DISEASE (NEUROHORMONAL FACTORS IN PATHOGENESIS AND TREATMENT)

1948; American College of Physicians; Volume: 28; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-28-5-1010

1539-3704

W Raab,

Nitric Oxide and Endothelin Effects

Article1 May 1948ADRENO-SYMPATHOGENIC HEART DISEASE (NEUROHORMONAL FACTORS IN PATHOGENESIS AND TREATMENT)W. RAAB, M.D., F.A.C.P.W. RAAB, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-5-1010 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost of the non-congenital and non-infectious forms of heart disease are generally attributed to mechanical factors, such as the "burden," "load," "strain" of high blood pressure in "hypertensive" heart disease or to impairment of coronary blood flow in "arteriosclerotic" heart disease. In either one of these conditions a relative or absolute deficiency of the myocardial oxygen supply is believed to exist and to contribute essentially to functional and ultimately structural lesions of the heart.Little or no emphasis is being put on the fact that the typical clinical features of "hypertensive" heart disease are not infrequently found without hypertension and...Bibliography1. BLIX G: Ueber Adrenalin als Oxydationskatalysator, Skandinav. Arch. f. Physiol., 1929, lvi, 131. CrossrefGoogle Scholar2. ROEST J: Oxydationskatalyse durch Adrenalin, Biochem. Ztschr., 1926, clxxvi, 17. Google Scholar3. AHLGREN G: Quoted by Blix, l.c. Skandinav. Arch. f. Physiol., 1925, xlvii (Supp. vol.). Google Scholar4. BARCROFTDIXON JWE: The gaseous metabolism of the mammalian heart, Jr. Physiol., 1906/7, xxxv, 182. Google Scholar5. EVANSOGAVA CLS: The effect of adrenaline on the gaseous metabolism of the isolated mammalian heart, Jr. Physiol., 1914, xlvii, 466. Google Scholar6. GREMELS H: Ueber die Steuerung der energetischen Vorgänge am Froschherzen, Arch. f. exper. Path. u. Pharmakol., 1936, clxxxii, 1. CrossrefGoogle Scholar7. REIN H: Ueber Adrenalin, Verhandl. deutsch. Ges. f. Kreislaufforsch., 1937, x, 27. Google Scholar8. GOLLWITZER-MEIERKRAMERKRÜGER KKE: Die Wirkung des Adrenalins auf die Energetik des Herzens, Arch. f. d. ges. Physiol., 1936, ccxxxvii, 639. CrossrefGoogle Scholar9. BÜLBRING E: The action of adrenaline on transmission in the superior cervical ganglion, Jr. Physiol., 1944, ciii, 55. CrossrefGoogle Scholar10. CANNONROSENBLUETH WBA: Studies on conditions of activity in endocrine organs: sympathin E and sympathin I, Am. Jr. Physiol., 1933, civ, 557. CrossrefGoogle Scholar11. RAAB W: (a) The pathogenic significance of adrenalin and related substances in the heart muscle, Exper. Med. and Surg., 1943, i, 188. (b) Epinephrine and related substances in human arterial walls and kidneys, Arch. Path., 1943, xxxv, 836. (c) Roentgen treatment of the adrenal glands in angina pectoris (100 cases), Ann. Int. Med., 1940, xiv, 688. (d) Blood level of adrenalin and related substances in various experimental and clinical conditions, Exper. Med. and Surg., 1943, i, 402. (e) Abnormal suprarenal discharges in angina pectoris and their control by x-ray therapy, Jr. Clin. Endocrin., 1941, i, 977.* (f) Epinephrine tolerance of the heart altered by thyroxin and thiouracil, Jr. Pharmacol. and Exper. Therap., 1944, lxxxii, 330. (g) Sudden death of a young athlete with an excessive concentration of epinephrine-like substances in the heart muscle, Arch. Path., 1943, xxxvi, 388. (h) Sudden death with an excessive myocardial concentration of epinephrine-like substances in a case of obesity and cystic thyroid disease, Arch. Path., 1944, xxxviii, 110. (i) Cardiovascular effects of desoxycorticosterone acetate in man, Am. Heart Jr., 1942, xxiv, 365. (j) The hormonal, central and renal origin of "essential" hypertension (cerebral and renal arteriosclerotic ischemia as causal factors), Ann. Int. Med., 1941, xiv, 1981.* (k) Adrenocortical compounds* in the blood. Relation of their quantity to arterial hypertension, renal insufficiency and congestive heart failure, Arch. Int. Med., 1941, lxviii, 713. (l) Cardiotoxic substances in the blood and heart muscle in uremia (their nature and action), Jr. Lab. and Clin. Med., 1944, xxix, 715. (m) Arteriosklerose-Entstehung und Nebennierenlipoid-Adrenalin-Komplex, Ztschr. f. exper. Med., 1939, cv, 657. (n) Thiouracil treatment of angina pectoris. Rationale and results, Jr. Am. Med. Assoc., 1945, cxxviii, 249. (o) Diminution of epinephrine sensitivity of the normal human heart through thiouracil, Jr. Lab. and Clin. Med., 1945, xxx, 774. (p) _____ and HUMPHREYS, R. J.: Secretory function of sympathetic neurones and sympathin formation in effector cells, Am. Jr. Physiol., 1947, cxlviii, 460. *See footnote p. 1012. (q) _____: Drug action upon myocardial epinephrine-sympathin concentration and heart rate, Jr. Pharmacol. and Exper. Therap., 1947, lxxxix, 64. (r) _____: Protective effect of adrenolytic drugs against fatal myocardial epinephrine concentrations, Jr. Pharm. and Exper. Therap., 1946, lxxxviii, 268. (s) _____ and MAES, J. P.: Effect of sympathectomy without and with adrenal inactivation on the concentration of epinephrine and related compounds in various tissues, Am. Jr. Physiol., 1947, cxlviii, 470. (t) _____ and SCHÖNBRUNNER, E.: Die Normalisierungstendenz des Elektrokardiogrammes nebennierenbestrahlter Angina pectoris-Kranker, Arch. f. Kreislaufforsch., 1939, iv, 362. (u) _____ and SOULE, A. B., JR.: Effect of Roentgen irradiation on the hormone content of the adrenal medulla, Radiology, 1943, xli, 56. (v) _____: Rationale and results of Roentgen treatment of the adrenal glands in angina pectoris, Am. Jr. Roentgenol., 1944, li, 364. (w) _____ and SUPPLEE, G. C.: Cardiotoxic adreno-sympathetic activity in vitamin B deficiencies, Exper. Med. and Surg., 1944, ii, 152. Google Scholar12. BURNSCRUICKSHANK WEW: Changes in creatine, phosphagen and adenylpyrophosphate in relation to the gaseous metabolism of the heart, Jr. Physiol., 1937, xci, 314. CrossrefGoogle Scholar13. WEICKER B: Adrenalin und Tätigkeitsstoffwechsel des Warmblüterherzens, Arch. f. exper. Path. u. Pharmak., 1936, clxxxi, 525. CrossrefGoogle Scholar14. DECHERDHERRMANNERHARD GGP: The effect of myocardial destructive agents on the creatine content of the rabbit's heart, Proc. Soc. Exper. Biol. and Med., 1936, xxxiii, 519. CrossrefGoogle Scholar15. SCHUMANN H: (a) Die Verminderung des Glykogens, des Phosphagens und der Adenylpyrophosphorsäure im Herzmuskel bei Sauerstoffmangel und nach ermüdender Arbeit normaler und trainierter Tiere, Ztschr. f. exper. Med., 1939, cvi, 59. (b) Der Einfluss der männlichen Sexualhormone auf den Glykogen-, Phosphagen- und Adenylpyrophosphatgehalt des Herzmuskels, Klin Wchnschr., 1939, xviii, 925. (c) Untersuchungen über den Muskelstoffwechsel des Herzens, Ergebn. d. inn. Med. u. Kinderheilk., 1943, lxiv, 869. CrossrefGoogle Scholar16. COWAN DW: The creatine content of the myocardium of normal and of abnormal human hearts, Am. Heart Jr., 1934, ix, 378. CrossrefGoogle Scholar17. DECHERDBLUM GMJE: Phosphorus fractions in human heart muscle, Proc. Soc. Exper. Biol. and Med., 1938, xxxviii, 341. CrossrefGoogle Scholar18. HERRMANNDECHERD GGM: The chemical nature of heart failure, Ann. Int. Med., 1939, xii, 1233. Google Scholar19. LINEGARFROSTMYERS CRTTVC: Variation in creatine content of human cardiac and voluntary muscle at autopsy, Arch. Int. Med., 1938, lxi, 430. CrossrefGoogle Scholar20. MYERSMANGUN VCGH: Some chemical observations on the human heart in health and disease, Jr. Lab. and Clin. Med., 1940, xxvi, 199. Google Scholar21. WILKINSCULLEN WEGE: Electrolytes in human tissue. A comparison of normal hearts with hearts showing congestive heart failure, Jr. Clin. Invest., 1933, xii, 1063. CrossrefGoogle Scholar22. ROBERTSON WV: Changes in the distribution of electrolytes and water in cardiac muscle produced by epinephrine (in preparation). Google Scholar23. KATZWEINMAN LNSF: The relation of the T wave to the asynchronism between the ends of right and left ventricular ejection, Am. Jr. Physiol., 1927, lxxxi, 360. CrossrefGoogle Scholar24. LEPESCHKIN EW: (a) Das Elektrokardiogramm, 1946, Th. Steinkopff, Dresden und Leipzig. (b) Ueber das Elektrokardiogramm bei experimenteller Koronarinsuffizienz, Cardiologia, 1938, ii, 236. Google Scholar25. LEVINEERNSTENEJACOBSON ASACBH: The use of epinephrine as a diagnostic test for angina pectoris, Arch. Int. Med., 1930, xlv, 191. CrossrefGoogle Scholar26. VESA A: (a) Untersuchungen über die Einwirkung des Adrenalins auf das Elektrokardiogramm, Acta Soc. Med. Fennicae "Duodecim," 1938, xxvi, 5 (Helsinki). (b) Das Elektrokardiogramm im Arbeitsversuch nach Adrenalininjektion, ibidem, 1939, xxvi, 3. Google Scholar27. TWISSSOKOLOW AM: Angina pectoris, Am. Heart Jr., 1942, xxiii, 498. CrossrefGoogle Scholar28. WOODWOLFERTH FCCC: Angina pectoris. The clinical and electrocardiographic phenomena of the attack and their comparison with the effects of experimental coronary occlusion, Arch. Int. Med., 1931, xlvii, 339. CrossrefGoogle Scholar29. MAINZERKRAUSE FM: The influence of fear on the electrocardiogram, Brit. Heart Jr., 1940, ii, 221. CrossrefGoogle Scholar30. CANNON WB: Bodily changes in pain, hunger, fear and rage, 1929, Appleton & Co., New York and London. CrossrefGoogle Scholar31. KATZHAMBURGERLEV LNWWM: Diagnostic value of epinephrine in angina pectoris, Am. Heart Jr., 1932, vii, 371. CrossrefGoogle Scholar32. COTTRELLWOOD JEFC: Effect of epinephrine in angina pectoris, Am. Jr. Med. Sci., 1931, clxxxi, 36. CrossrefGoogle Scholar33. WENCKEBACH KF: Herz- und Kreislaufinsuffizienz, 1932, Th. Steinkopff, Dresden. Google Scholar34. KOBRO MS: Nikotinwirkung und Adrenalinsekretion, 1936, Johan Grundt Tanum, Oslo. Google Scholar35. EICHHOLTZ F: Ueber den Einfluss von Nikotin und nikotinartig wirkenden Substanzen auf die Adrenalinsekretion, Arch. f. exper. Path. u. Pharmak., 1923, xcix, 172. CrossrefGoogle Scholar36. CANNONAUBBINGER WBJCCA: Note on effect of nicotine injection on adrenalin secretion, Jr. Pharm. and Exper. Therap., 1911/12, iii, 379. Google Scholar37. DENEKE T: Tabak und Angina pectoris, Ztschr. f. ärztl. Fortbild., 1936, xxxiii, 573. Google Scholar38. LABARREHOUSSA JP: À propos des variations de l'adrénalinémie au cours de l'hypoglycémie insulinique, Compt. rend. Soc. d. biol., 1932, cix, 967. Google Scholar39. KUGELMANN B: Zur Frage der Adrenalinausschüttung bei der Insulinhypoglykämie und bei Pal'schen Gefässkrisen, Klin. Wchnschr., 1933, xii, 1488. CrossrefGoogle Scholar40. BRANDTKATZ FG: Ueber den Nachweis von Adrenalinsekretion beim Menschen, Ztschr. f. klin. Med., 1933, cxxiii, 40. Google Scholar41. SCHOU HJ: Complications concerning shock therapy, Acta physiol. et neurol., 1942, xvii, 277. Google Scholar42. GRALNICH A: Pulmonary edema and EKG findings resembling coronary occlusion in insulin treatment, Psychiat. Quart., 1944, xviii, 650. CrossrefGoogle Scholar43. GILBERTGOLDZIEHER RAJW: The mechanism and prevention of cardiovascular changes due to insulin, Ann. Int. Med., 1946, xxv, 928. Google Scholar44. NUZUMDALTON FRJW: Paroxysmal and persistent hypertension in association with lesions of adrenal glands, Am. Heart Jr., 1938, xvi, 643. CrossrefGoogle Scholar45. BRUNSCHWIGHUMPHREYSROOME AENW: Relief of paroxysmal hypertension by excision of pheochromocytoma, Surgery, 1938, iv, 361. Google Scholar46. LENHARTZ H: Ueber paroxysmale Blutdrucksteigerungen, Klin. Wchnschr., 1939, xviii, 109. Google Scholar47. RATNOFFPLOTZ ODM: The coronary circulation, Medicine, 1946, xxv, 285. CrossrefGoogle Scholar48. TILMANN O: Chromaffiner Tumor als Todesursache, Beitr. z. path. Anat. u. z. allg. Path., 1935, xcv, 60. Google Scholar49. PAUL F: Die krankhafte Funktion der Nebenniere und ihr gestaltlicher Ausdruck, Virchow's Arch. f. path. Anat., 1931, cclxxxii, 256. CrossrefGoogle Scholar50. WICKENHÄUSER K: Der plötzliche oder ziemlich plötzliche Tod bei Nebennierenmarktumoren und seine Bedeutung für die gerichtliche Medizin, Deutsch. Ztschr. f. gerichtl. Med., 1939, xxxi, 97. Google Scholar51. MINOVICIBONCIU NC: La mort subite dans un cas de paragangliome surrénal bilatéral, Bull. Acad. de méd. de Roumanie, 1936, i, 638. Google Scholar52. HOLTZ E: Plötzlicher Tod bei Phäochromozytom der Nebenniere, Deutsch. Ztschr. f. d. ges. gerichtl. Med., 1939, xxxii, 94. Google Scholar53. SIMPSON CK: Pathology of the adrenal gland in relation to sudden death, Lancet, 1937, i, 851. CrossrefGoogle Scholar54. KRUSE WE: A statistical analysis of 1700 sudden and violent deaths, Jr. Indiana Med. Assoc., 1940, xxxiii, 509. Google Scholar55. SEVERN AG: Acute bilateral suprarenal hemorrhage, Lancet, 1923, i, 647. CrossrefGoogle Scholar56. HENDERSONPETTIGREW JAF: Sudden death from hemorrhage into suprarenal capsules in a child, Brit. Med. Jr., 1932, i, 14. Google Scholar57. DAMON LA: Bilateral suprarenal hemorrhage as cause of sudden death in epilepsy, Psychiat. Quart., 1932, vi, 438. CrossrefGoogle Scholar58. FISHER RS: Personal communication (Harvard Medical School, Dept. of Legal Medicine). Google Scholar59. MARKOWITZ B: Sudden death. A neurocirculatory disturbance, Am. Jr. Clin. Path., 1942, xii, 276. CrossrefGoogle Scholar60. BOHRAD : Quoted by Markowitz, l.c. Google Scholar61. Brisard C: La mort subite préopératoire, Ann. de méd. lég., 1937, xvii, 1057. Google Scholar62. MARTINROYO VILLANOVA Y MORALES ER: Muerte imprevista y "shock" emocional, Siglo Méd., 1929, lxxxiii, 485. Google Scholar63. STEFAN H: Ueber den plötzlichen natürlichen Tod infolge hochgradiger Erregung bei akuten Psychosen ohne wesentliche anatomisch nachweisbare Ursache, Ztschr. f. d. ges. Neurol. u. Psychiat., 1935, cvii, 480. CrossrefGoogle Scholar64. LEVYBRUENN RLHG: Acute fatal coronary insufficiency, Jr. Am. Med. Assoc., 1936, cvi, 1080. CrossrefGoogle Scholar65. BRACKPLASSMANNKRÜGER EKE: Ueber den Zusammenhang zwischen plötzlichem Tode, Herzhypertrophie und Nebennierenveränderungen, Ztschr. f. Kreislaufforsch., 1930, xxii, 210. Google Scholar66. WEYRICH G: Erfahrungen über den plötzlichen Tod aus innerer Ursache bei Kindern und Jugendlichen, Deutsch. Ztschr. f. d. ges. gerichtl. Med., 1933, xxii, 116. Google Scholar67. KITCHIN DH: Sudden death at work, Med. Legal and Criminol. Revue, 1934, ii, 195. CrossrefGoogle Scholar68. MARRADI-FABRONI S: L'affaticamento, il fattore tossico e morboso nella dottrina della morte apparenti e improvvise, Riforma med., 1934, l, 999. Google Scholar69. BÖHMIG R: Plötzliche Todesfälle bei Jugendlichen der Wehrmacht und des Reichsarbeitsdienstes, Med. Klin., 1940, xxxvi, 209. Google Scholar70. MANGILI C: Sport e morte improvvisa, Arch. di antropol. crim., psichiatr. e med. leg., 1937, lvii, 694. Google Scholar71. FRENCHDOCK AJW: Fatal coronary arteriosclerosis in young soldiers, Jr. Am. Med. Assoc., 1944, cxxiv, 1233. CrossrefGoogle Scholar72. MORITZZAMCHECK ARN: Sudden and unexpected death of young soldiers, Arch. Path., 1947, xlii, 459. Google Scholar73. STEPPUHNNAUMOVAUGAROVA ONN: Chemical and pharmacodynamic characteristics of the heart in hyperthyroidism, Klinicheskaya Meditsina, 1935, xiii, 1265 (Russian). Google Scholar74. WISEHOFF BHE: The effect of autonomic hormones on the thyrotoxic heart, Jr. Pharm. and Exper. Therap., 1938, lxvi, 217. Google Scholar75. AUMANNYOUMANS KWWB: Differential sensitization of adrenergic neuro-effector system by thyroid hormone, Am. Jr. Physiol., 1940, cxxxi, 394. CrossrefGoogle Scholar76. SAWYERBROWN MEMG: Effect of thyroidectomy and thyroxin on the response of the denervated heart to injected and secreted adrenine, Am. Jr. Physiol., 1935, cx, 620. Google Scholar77. SADAE O: On the sensitizing action of thyroid extract for adrenalin, Jap. Med. World, 1922, ii, 157. Google Scholar78. LÜTOLF W: Untersuchungen über die Sensibilisierung von Adrenalin durch Thyroxin am überlebenden Säugetierherzen, Ztschr. f. Biol., 1930, xc, 334. Google Scholar79. WEISSWILKINS SRW: The nature of the cardiovascular disturbances in vitamin deficiency states (beriberi), Ann. Int. Med., 1937, xi, 104. LinkGoogle Scholar80. MEANSHERTZLERMAN JHSJ: Nutritional factors in Graves' disease, Ann. Int. Med., 1937, xi, 429. Google Scholar81. LIKOFFLEVINE WBSA: Thyrotoxicosis as the sole cause of heart failure, Am. Jr. Med. Sci., 1943, ccvi, 425. CrossrefGoogle Scholar82. WILLIAMSEGANAROBINSONASPERDUTOIT RHEPSPC: Alterations in biologic oxidation in thyrotoxicosis, Arch. Int. Med., 1943, lxxii, 353. CrossrefGoogle Scholar83. SÁRFY E: Adrenalin in Nebennieren und Blut B1-avinaminotischer Tauben und Ratten, Ztschr. f. physiol. Chem., 1939, cclxii, 87. Google Scholar84. DUSTINWEYLERROBERTS CCHCP: Electrocardiographic changes in vitamin B1-deficiency, New Eng. Jr. Med., 1939, ccxx, 15. CrossrefGoogle Scholar85. DE SOLDATI L: Los trastornos circulatorios del perro en avitaminosis B1 , Rev. Soc. Argent. de biol., 1939, xv, 142. Google Scholar86. WEISSHAYNESZOLL SFWPM: Electrocardiographic manifestations and the cardiac effect of drugs in vitamin B1 deficiency in rats, Am. Heart Jr., 1938, xv, 206. CrossrefGoogle Scholar87. SWANKPORTERYEOMANS RLRRA: The production and study of cardiac failure in thiamin deficient dogs, Am. Heart Jr., 1941, xxii, 154. CrossrefGoogle Scholar88. WINTROBEALCAYAGAHUMPHREYSFOLLIS MMRSRH: Electrocardiographic changes associated with thiamin deficiency in pigs, Bull. Johns Hopkins Hosp., 1943, lxxiii, 169. Google Scholar89. WENCKEBACH KF: Das Beriberi-Herz, 1934, J. Springer, Berlin. CrossrefGoogle Scholar90. PORTODE SOLDATI JL: Alteraciones microscopicas del corazon del perro en avitaminosis B1 , Rev. Soc. Argent. de biol., 1939, xv, 303. Google Scholar91. VAN ETTENELLISMADSEN CNRLL: Studies on the thiamin requirement, Jr. Nutr., 1940, xx, 607. CrossrefGoogle Scholar92. FOLLISMILLERWINTROBESTEIN RHMHMMHJ: Development of myocardial necrosis and absence of nerve degeneration in thiamin deficiency in pigs, Am. Jr. Physiol., 1943, xix, 341. Google Scholar93. ASHBURNLOWRY LLJV: Development of cardiac lesions in thiamin deficient rats, Arch. Path., 1944, xxxvii, 27. Google Scholar94. WEISS S: Occidental beriberi with cardiovascular manifestations, Jr. Am. Med. Assoc., 1940, cxv, 832. CrossrefGoogle Scholar95. MARTINLISSÁK JK: Acetylcholinempfindlichkeit und Vitamin B1 , Arch. f. exper. Path. u. Pharm., 1941, cxcviii, 667. CrossrefGoogle Scholar96. BEZNAKPERJES AJ: Die Beziehung der Nebennierenrindenhypertrophie zu Muskelarbeit und Vitamin B-Gehalt der Nahrung, Arch. f. d. ges. Physiol., 1935, ccxxxvi, 181. CrossrefGoogle Scholar97. LOCKWOODHARTMAN JAFA: Relation of the adrenal cortex to vitamins A, B and C, Endocrin., 1933, xvii, 501. CrossrefGoogle Scholar98. GOODSELL JE: Weight changes in the cortex and the medulla of the adrenal gland of the dog in acute vitamin B1 deficiency, Am. Jr. Physiol., 1941, cxxxiv, 119. CrossrefGoogle Scholar99. CASTLEMANSMITHWICK BRH: The relation of vascular disease to hypertensive state, Jr. Am. Med. Assoc., 1943, cxxi, 1256. CrossrefGoogle Scholar100. GREGORYEWINGLEVINROSS RPLWCGT: Studies on hypertension. IV. Bioassay of vasoconstrictor substances in ultrafiltrates of citrated blood plasma from patients with normal blood pressures, patients with essential hypertension and patients made hypertensive by intravenous injection of angiotonin (hypertensin), Arch. Int. Med., 1945, lxxvi, 11. Google Scholar101. SMITHWICK RH: Surgical treatment of hypertension, Arch. Surg., 1944, xlix, 180. CrossrefGoogle Scholar102. GRIMSONWILSONPHEMISTER KSHDB: The early and remote effects of total and partial paravertebral sympathectomy on blood pressure, Ann. Surg., 1937, cvi, 801. CrossrefGoogle Scholar103. NOWAKWALKER JGJJ: Experimental studies concerning the nature of hypertension, New Eng. Jr. Med., 1939, ccxx, 269. CrossrefGoogle Scholar104. FISHBACKDUTRAMCCAMY HRFEET: The production of chronic hypertension in dogs by progressive ligation of arteries supplying the head, Jr. Lab. and Clin. Med., 1943, xxviii, 1. Google Scholar105. MASTER AM: Characteristic electrocardiograms and roentgenograms in arterial hypertension, Am. Heart Jr., 1930, v, 291. CrossrefGoogle Scholar106. EVANSMATHEWSWHITE EMPD: The electrocardiogram in hypertension, Am. Heart Jr., 1945, xxx, 140. CrossrefGoogle Scholar107. CANABALWARNEFORD-THOMSONWHITE EJHFPD: The electrocardiogram in hypertension, Am. Heart Jr., 1945, xxx, 189. CrossrefGoogle Scholar108. BRIDGESJOHNSONSMITHWICKWHITE WCALRHPD: Electrocardiography in hypertension, Jr. Am. Med. Assoc., 1946, cxxxi, 1476. CrossrefGoogle Scholar109. SCHERF D: The short P-R interval and its occurrence in hypertension, Bull. N. Y. Med. Coll., Flower and Fifth Ave. Hospitals, 1941, iv, 116. Google Scholar110. WHITESMITHWICKMATHEWSEVANS PDRHMWE: The electrocardiogram in hypertension, Am. Heart Jr., 1945, xxx, 165. CrossrefGoogle Scholar111. GOLDZIEHERSHERMAN MAJ: Hypertrophy of muscle in suprarenal vein in hypertension, Arch. Path., 1928, v, 1. Google Scholar112. ALLEN EV: The suprarenal glands and hypertension, Ann. Int. Med., 1930, iii, 153. Google Scholar113. JOSUÉ O: Hypertrophie cardiaque causée par l'adrénaline, Compt. rend. Soc. biol., 1907, lxiii, 285. Google Scholar114. ANITSCHKOW N: Ueber die Histogenese der Myocardveränderungen bei einigen Intoxikationen, Virchow's Arch. f. path. Anat., 1913, ccxi, 193. CrossrefGoogle Scholar115. D'AMATO L: Weitere Untersuchungen über die von Nebennierenextrakten bewirkten Veränderungen, Berlin. klin. Wchnschr., 1906, No. 33/34, 1100 and 1131. Google Scholar116. FLEISHERLOEB MSL: Ueber experimentelle Myocarditis, Zentralbl. f. Path., 1909, xx, 104. Google Scholar117. PEARCE RM: Experimental myocarditis; a study of the histological changes following intravenous injections of adrenalin, Jr. Exper. Med., 1906, viii, 400. CrossrefGoogle Scholar118. FRANZ G: Eine seltene Form von toxischer Myokardschädigung, Virchow's Arch. f. path. Anat., 1937, ccxcviii, 743. CrossrefGoogle Scholar119. BIEBLWICHELS MP: Physiologische und pathologisch-anatomische Betrachtungen im Anschluss an einen Fall von Paragangliom beider Nebennieren, Virchow's Arch. f. path. Anat., 1926, cclvii, 182; München. med. Wchnschr., 1928, ii, 656. Google Scholar120. HAUSMANNGETZOWA MS: Ein Paragangliom des Zuckerkandl'schen Organs mit gleichzeitiger Herz- und Nierenhypertrophie, Schweiz. med. Wchnschr., 1922, No. 36, 889 and No. 37, 911. Google Scholar121. SANDERS E: Ueber die Wirkung von reinem Adrenalin und Nebennierenextrakten per os und am isolierten Organ, Arch. exper. Path. u. Pharmak., 1938, clxxxviii, 657. CrossrefGoogle Scholar122. DARROW DC: Effect of low potassium diet and desoxycorticosterone on the rat heart, Proc. Soc. Exper. Biol. and Med., 1944, lv, 13. CrossrefGoogle Scholar123. HEGGLINNABHOLZ RH: Das Nebennierenmarksyndrom, Zur Kasuistik der chromaffinen Geschwülste, Ztschr. f. klin. Med., 1938, cxxxiv, 161. Google Scholar124. KAULBACH G: Ein weiterer Beitrag zur Kenntnis der malignen Phaeochromocytome, Zentralbl. f. Path., 1937, lxvii, 49. Google Scholar125. OPSAHL R: Zur Pathogenese der arteriellen Hypertension, 1938, J. Grundt Tanum, Oslo. Google Scholar126. RICHTER D: The inactivation of adrenaline in vivo in man, Jr. Physiol., 1940, xcviii, 361. CrossrefGoogle Scholar127. BEYERSHAPIRO KHSH: The excretion of conjugated epinephrine related compounds, Am. Jr. Physiol., 1945, cxliv, 321. CrossrefGoogle Scholar128. WOODWHITE JEPD: The electrocardiogram in uremia and severe chronic nephritis with nitrogen retention, Am. Jr. Med. Sci., 1925, clxix, 76. CrossrefGoogle Scholar129. BECHER E: (a) Studien über die Pathogenese der echten Urämie, Zentralbl. inn. Med., 1925, xlvi, 369. (b) Pathogenese, Symptomatologie und Therapie der Urämie, Ergeb. d. ges. Med., 1933, xviii, 51. Google Scholar130. GOULEY BA: The myocardial degeneration associated with uremia in advanced hypertensive disease and chronic glomerular nephritis, Am. Jr. Med. Sci., 1940, cc, 39. CrossrefGoogle Scholar131. AGNOLIBUSSA RD: Ricerche cliniche e sperimentali sulle alterazioni electrocardiografiche esistenti nell'uremia, Cuore e circolaz, 1939, xxiii, 2. Google Scholar132. KEITHPRUITTBAGGENSTOSS NMRDA: Electrocardiographic changes in pericarditis associated with uremia, Am. Heart Jr., 1946, xxxi, 527. CrossrefGoogle Scholar133. LÜSCHER W: Ueber Myocarditis uraemica, Frankf. Ztschr. f. Path., 1922, xxvi, 293 (quoted by Gouley, l. c.). Google Scholar134. SOLOMONROBERTSLISA CERJ: The heart in uremia, Am. Jr. Path., 1942, xviii, 729. Google Scholar135. KÜLBS F: "Krankheiten der Kreislaufsorgane" in Mohr-Stähelins Lehrbuch der Inneren Medizin, ed. 1 (quoted by Agnoli and Bussa, l. c.). Google Scholar136. MERKLENRABÉ : V. Congr. de méd. Française, Lille, 1899 (quoted by Agnoli and Bussa, l. c.). Google Scholar137. GROSSSANDBERG HM: The concentration of creatine in heart, diaphragm and skeletal muscle in uremia, Ann. Int. Med., 1942, xvi, 737. Google Scholar138. HOFFSMITHWINKLER HEPKAW: The cause of death in experimental anuria, Jr. Clin. Invest., 1941, xx, 607. CrossrefGoogle Scholar139. MARCHANDFINCH JFCA: Fatal spontaneous potassium intoxication in patients with uremia, Arch. Int. Med., 1944, lxxiii, 384. CrossrefGoogle Scholar140. KEITHBURCHELLBAGGENSTOSS NMHBA: Electrocardiographic changes in uremia associated with a high concentration of serum potassium, Am. Heart Jr., 1944, xxvii, 817. CrossrefGoogle Scholar141. MARCOLONGO F: Ricerche cliniche e sperimentali sui fenoli nell-uremia, Riv. di pat. sper., 1937, viii, 450. Google Scholar142. DICKES R: Relation between the symptoms of uremia and the blood levels of the phenols, Arch. Int. Med., 1942, lxix, 446. CrossrefGoogle Scholar143. DANISCH F: Die sympathischen Ganglien in ihrer Bedeutung für die Cholesterinsklerose des Kaninchens, Beitr. z. path. Anat. u. allg. Path., 1928, lxxix, 333. Google Scholar144. DOLGIN W: Pheochromocytoma and sudden death following injury of the head, Arch. Path., 1945, xl, 135. Google Scholar145. LERICHEFROELICH RF: Recherches expérimentales sur l'origine des artérites oblitérantes. Production d'artérites oblitérantes à la suite de greffes répétées de surrénales, Ann. d'anat. path., 1936, xiii, 1039. Google Scholar146. MAGGIMAZOCCHI NE: Alterazioni vascolari nell'ipersurrenalismo sperimentale, Arch. Ital. de Chirurg., 1933, xxxv, fasc. 4. Google Scholar147. SELYEHALL HCE: Pathologic changes induced in various species by overdosage with desoxycorticosterone, Arch. Path., 1943, xxxvi, 19. Google Scholar148. FORSTERCANTAROWHERBERTPASCHKISRAKOFF FMAPAKEAE: Degenerative changes in cerebral arteries following administration of desoxycorticosterone acetate, Jr. Clin. Endocrin., 1946, vi, 77. CrossrefGoogle Scholar149. SCHMIDTMANN M: Experimentelle Kranzarteriensklerose, Verhandl. d. deutsch. Ges. f. Kreislaufforsch., 1932, v, 283. Google Scholar150. WHITE PD: The heart in sympathectomized hypertensive patients, Trans. Am. Coll. Phys., Philadelphia, 1946. Google Scholar151. HADORN W: (a) Untersuchungen des Herzens im hypoglykämischen Schock, Arch. f. Kreislaufforsch., 1937, ii, 70. (b) Behandlung der Angina pectoris, Praxis, 1937, No. 20, 285. CrossrefGoogle Scholar152. SCHITTENHELM A: Aus dem Indikationsgebiet der Strahlenbehandlung von Hypophyse, Schilddrüse und Nebenniere, Strahlentherapie, 1939, lxvi, 373. Google Scholar153. LIPPROSS O: Zur Pathologie und Therapie der Angina pectoris, München. med. Wchnschr., 1940, No. 87, 727. Google Scholar154. KIENLE : Praktische Elektrokardiographie, 1944, G. Thieme, Leipzig, p. 150. Google Scholar155. RINEHARTWILLIAMSCAPPELLER JFOOWS: Adenomatous hyperplasia of the adrenal cortex associated with essential hypertension, Arch. Path., 1941, xxxii, 169. Google Scholar156. RUSSIBLUMENTHAL SHT: Small adenomas of the adrenal cortex in hypertension and diabetes, Arch. Int. Med., 1945, lxxvi, 284. CrossrefGoogle Scholar157. BLUMGARTLEVINEBERLIN HLSADD: Congestive heart failure and angina pectoris; therapeutic effect of thyroidectomy on patients without clinical or pathologic evidence of thyroid toxicity, Arch. Int. Med., 1933, li, 866. CrossrefGoogle Scholar158. CLAIBORNEHURXTHAL TSLM: Results of total thyroidectomy in heart disease, New England Jr. Med., 1937, ccxvi, 411. CrossrefGoogle Scholar159. CLARKMEANSSPRAGUE RJJHHB: Total thyroidectomy for heart disease, New England Jr. Med., 1936, ccxiv, 277. CrossrefGoogle Scholar160. BEN ASHER S: (a) The treatment of anginal syndrome with thiouracil, Jr. Med. Soc. New Jersey, 1945, xlii, 401. (b) Further observations on the treatment of the anginal syndrome with thiouracil, Am. Heart Jr., 1947, xxxiii, 491. Google Scholar161. DI PALMAMCGOVERN JRJJ: Disadvantages of thiouracil treatment of angina pectoris, Am. Heart Jr., 1946, xxxii, 494. CrossrefGoogle Scholar162. ASTWOODVANDERLAAN EBWP: Thiouracil derivatives of greater activity for the treatment of hyperthyroidism, Jr. Clin. Endocrinol., 1945, v, 424. CrossrefGoogle Scholar163. VEITH G: Experimentelle Untersuchungen zur Wirkung von Adrenalin auf den Herzmuskel, Arch. f. Kreislaufforsch., 1940, vi, 335. CrossrefGoogle Scholar164. PICK R: Die hormonale Behandlung der Keimdrüseninsuffizienz beim Manne mit Berücksichtigung des synthetischen Testosteron-propionate Perandren, Med. Klin., 1938, xxxiv, 17. Google Scholar165. HENSSGE E: Die Beseitigung vasomotorischer Störungen durch Testoviron und eine vergleichende Darstellung über die Wirkung männlicher Hormone, Aerztl. Korrespond., 1937, xxi, 537. Google Scholar166. ARNDT H: Zur Therapie extragenitaler Störungen mit Sexualhormonen, Wien. med. Wchnschr., 1939, lxxxix, 222. Google Scholar167. WALKER TC: Use of testosterone propionate and estrogenic substance in cardiovascular disease, Med. Rec. and Ann., 1940, xxxiv, 667. Google Scholar168. BONNELLPRITCHETTRARDIN RWCPTE: Treatment of angina pectoris and coronary artery disease with sex hormones, Ohio State Med. Jr., 1941, xxxvii, 554. Google Scholar169. LESSER MA: (a) Treatment of angina pectoris with testosterone propionate, New England Jr. Med.