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CD1a down‐regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome

2007; Wiley; Volume: 52; Issue: 2 Linguagem: Inglês

10.1111/j.1365-2559.2007.02919.x

1365-2559

Giampiero La Rocca, Rita Anzalone, Simona Corrao, Francesca Magno, Francesca Rappa, S Marasà, Anna M. Czarnecka, L Marasà, Consolato Sergi, G. Zummo, Francesco Cappello,

Cancer Immunotherapy and Biomarkers

Aims: CD1a is a molecule belonging to the highly conserved group of CD1 proteins. Its expression in dendritic cells is related to the presentation of tumour‐derived glycolipid antigens to T cells and, consequently, the development of a successful antitumour response. The aim was to investigate the presence of CD1a+ cells in both primary tumours and lymph nodes (LN) of a series of 35 invasive ductal carcinomas by both immunohistochemistry and reverse transcription‐polymerase chain reaction. Methods and results: CD1a antigen was more expressed in N0 than N1 breast cancer ( P < 0.0001) in both primary lesions and LN metastases and correlated positively and significantly with oestrogen (ER) ( P = 0.0025) and progesterone ( P = 0.0226) receptor (PR) status, as well as CD4+ and CD8+ T‐lymphocyte infiltration. Conclusions: This is the first report to show a link between CD1a+ mononuclear cells in breast cancer and in paired LN metastases. The positive and significant correlations between the number of CD1a+ cells and positivity of the primary tumour for ER and PR suggest a possible role for CD1a as a prognostic marker for breast cancer, raising the possibility that hormone receptor‐positive breast cancer patients may have a better prognosis in the presence of greater dendritic cell infiltration.