Vitamin D: Can an Upper Limit be Defined?
1989; Elsevier BV; Volume: 119; Linguagem: Inglês
10.1093/jn/119.12_suppl.1825
ISSN1541-6100
Autores Tópico(s)Connective tissue disorders research
ResumoVitamin D ingested in excess results in hypercalcemia, which is caused by excessive absorption of massive quantities of calcium by the intestine and enhanced bone resorption. The symptoms of this intoxication include feeding difficulties, polydypsia, polyuria, irritability, lassitude and poor weight gain. Because daily intakes of 400 KI (10 µg) of vitamin D2 or D3 are completely safe, and because as low as 100 KI (2.5 µg) daily may prevent rickets, it is difficult to justify recent studies that attempt to firmly establish an upper limit of daily vitamin D intake in the normal neonate. Thus, despite efforts to better understand the upper limits of daily vitamin D intake, a concentration of 100 KI (2.5 µg) of vitamin D per 100 kcal ingested, as is currently recommended by the Committee on Nutrition of the American Academy of Pediatrics, seems entirely appropriate.
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