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Plasma volume, electrolyte, and coagulation factor changes following intra-amniotic hypertonic saline infusion

1972; Elsevier BV; Volume: 113; Issue: 8 Linguagem: Inglês

10.1016/0002-9378(72)90737-5

1097-6868

William E. Easterling, Andrew E. Weiss, M.H. Odom, Luther M. Talbert,

Maternal and Perinatal Health Interventions

To determine the relationship of coagulapathy to saline infusions for abortion, plasma volume, electrolyte, and coagulation factors were studied in 6 patients of a gestational average of 18 weeks undergoing intraamniotic hypertonic saline infusion for therapeutic abortion. Blood samples were taken before the operation and afterwards at 3-hour intervals for 30 hours. Mean plasma volume increased by 8.9% of the base-line values by 15 hours. The direct correlation found between fluid intake, weight, and plasma volume indicates that unlimited fluid intake may be allowed following saline infusion. Serum electrolytes showed no significant change. Urine sodium and chloride increased at 3 hours, reaching a peak of 60 meg at 27 hours, and returning to base-line values at 36 hours. Urine potassium decreased at 3 hours and remained slightly below base-line values for the remainder of the test period. Disperse variations in the coagulation factor studies might suggest mild diffuse intravascular coagulation, but further research is required.