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BIBTEX RIS

Dor: aspectos atuais da sensibilização periférica e central

2007; Elsevier BV; Volume: 57; Issue: 1 Linguagem: Inglês

10.1590/s0034-70942007000100011

1806-907X

Anita Perpétua Carvalho Rocha, Durval Campos Kraychete, Lino Lemônica, Lídia Raquel de Carvalho, Guilherme Antônio Moreira de Barros, João Batista dos Santos Garcia, Rioko Kimiko Sakata,

Pain Mechanisms and Treatments

Current research has focused on the biochemical and structural plasticity of the nervous system secondary to tissue injury. The mechanisms involved in the transition from acute to chronic pain are complex and involve the interaction of receptor systems and the flow of intracellular ions, second messenger systems, and new synaptic connections. The aim of this article was to discuss the new mechanisms concerning peripheral and central sensitization.Tissue injury increases the response of nociceptors, known as sensitization or facilitation. These phenomena begin after the local release of inflammatory mediators and the activation of the cells of the immune system or specific receptors in the peripheral and central nervous system.Tissue and neuronal lesions result in sensitization of the nociceptors and facilitation of the central and peripheral nervous conduction.