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PERFIL DE SENSIBILIDADE DE BACTÉRIAS PATOGÊNICAS ISOLADAS DE CÃES FRENTE A ANTIMICROBIANOS. / SENSITIVITY PROFILE OF PATHOGENIC ISOLATED BACTERIA FROM DOGS FACING ANTIMICROBIAL. / PERFIL DE LA SENSIBILIDAD DE BACTERIAS PATÓGENAS AISLADAS DE PERROS FRENTE

2012; Volume: 19; Issue: 4 Linguagem: Espanhol

2178-3764

Amanda Keller Siqueira Paes,

Antibiotics Pharmacokinetics and Efficacy

RESUMO A passagem de bacterias resistentes dos animais ao homem e possivel. As amostras foram coletadas de caes, machos e femeas, de diferentes racas e idade, com infeccoes bacterianas variadas. Foram realizadas cultura e antibiograma das bacterias isoladas (n=100), sendo avaliadas como sensiveis ou resistentes. Porcentagem de resistencia do grupo das bacterias Gram-negativas: tetraciclina 83,02%, azitromicina 81,48%, doxiciclina 77,78%, ampicilina 62,96%, ceftiofur e florfenicol 50%, cefalexina 46,3%, enrofloxacino 44,44%, norfloxacino 18,52%, gentamicina 20,37%, levofloxacino 27,78%, amoxicilina + acido clavulânico 31,48%, ciprofloxacino 31,48%, amicacina e ceftriaxona 33,33%, cloranfenicol e sulfa + trimetoprin 35,19%. Porcentagem de resistencia do grupo dos Streptococcus : tetraciclina 80%, eritromicina 72%, enrofloxacino e levofloxacino 52%, ampicilina, azitromicina, ciprofloxacino, norfloxacino, penicilina G e sulfa + trimetoprin 48%, amoxicilina + acido clavulânico 4%, cefalexina 12%, florfenicol 24%, ceftiofur, ceftriaxona e oxacilina 28%, cloranfenicol 32%. Porcentagem de resistencia do grupo dos Staphylococcus spp: ampicilina 57,14%, sulfa + trimetoprin e tetraciclina 52,38%, amicacina, amoxicilina + acido clavulânico, gentamicina, levofloxacino, 4,76%; cefalexina, ceftiofur, ceftriaxona e cloranfenicol, 9,52%; vancomicina 13,33%, norfloxacino 19,05%; ciprofloxacino, enrofloxacino e oxacilina 23,81% e azitromicina 33,33%. Os caes sao reservatorios de bacterias multidrogas resistentes que podem transmitir por meio de plasmidios os genes de resistencia, explicando a resistencia de bacterias isoladas de caes a antimicrobianos de uso humano como a vancomicina. Palavras-chave: bacterias multidrogas resistentes, antimicrobianos, caes SENSITIVITY PROFILE OF PATHOGENIC ISOLATED BACTERIA FROM DOGS FACING ANTIMICROBIAL ABSTRACT The transmission of resistant bacteria from animals to humans is possible. Samples were collected from different breeds of dogs in different ages including males and females, with a variety of bacterial infections. The culture and antibiograma of isolated bacteria were analysed (n = 100), being evaluated as sensitive or resistant. Percentage of resistance of Gram-negative bacteria tetracycline 83.02%, azithromycin 81.48%, doxycycline 77.78%, ampicillin 62.96%, ceftiofur and florfenicol 50%, cephalexin 46,3%, enrofloxacin 44.44%, norfloxacin 18.52%, gentamicin 20.37%, levofloxacin 27.78%, amoxicillin + clavulanic acid 31.48%, ciprofloxacin 31.48%, amikacin and ceftriaxone 33.33%, chloramphenicol and trimethoprim + sulfa (35.19%). Percentage of resistance of Streptococcus : tetracycline 80%, erythromycin 72%, enrofloxacin and levofloxacin 52%, ampicillin, azithromycin, ciprofloxacin, norfloxacin, penicillin G and sulfamethoxazole + trimethoprim 48%, amoxicillin + clavulanic acid 4%, cephalexin 12%, florfenicol 24%, ceftiofur, ceftriaxone, and oxacillin 28%, chloramphenicol 32%. Percentage of resistance of Staphylococcus spp: ampicillin 57.14%, sulfamethoxazole + trimethoprim and tetracycline 52.38%, amikacin, amoxicillin + clavulanic acid, gentamicin, levofloxacin, 4.76%, cephalexin, ceftiofur, ceftriaxone, and chloramphenicol 9.52%, vancomycin 13.33%, norfloxacin 19.05% ciprofloxacin, enrofloxacin and oxacillin 23.81% and azithromycin 33.33%. Dogs have resistant-multidrug bacteria that might pass through the plasmid resistant genes, explaining the resistance of isolated bacteria from dogs to human use of antimicrobials such as vancomycin. Keywords: resistant-multidrug bacteria, antimicrobial, dogs PERFIL DE LA SENSIBILIDAD DE BACTERIAS PATOGENAS AISLADAS DE PERROS FRENTE A LOS ANTIMICROBIANOS RESUMEN La transmision de bacterias resistentes de animales a los seres humanos es posible. Se obtuvieron muestras provenientes de perros, machos y hembras, de diferentes razas y edades, afectados por infecciones bacterianas miscelaneas. Se analizaron los cultivos y antibiogramas de las bacterias aisladas (n=100), mismas que fueron clasificadas como sensibles o resistentes. Asi, fueron obtenidos los siguientes porcentajes de resistencia entre las bacterias Gram-negativas: tetraciclina 83.02%, azitromicina 81.48%, doxiciclina 77.78%, ampicilina 62.96%, ceftiofur y florfenicol el 50%, cefalexina 46.3%, enrofloxacina 44.44%, norfloxacina 18.52%, gentamicina 20.37%, levofloxacina 27.78%, amoxicilina + acido clavulanico 31.48%, ciprofloxacina 31.48%, amikacina y ceftriaxona 33.33%, cloranfenicol y sulfametoxazol + trimetoprima 35.19%; entre el grupo de Streptocccus spp: tetraciclina 80%, eritromicina 72%, enrofloxacina y levofloxacina el 52%, ampicilina, azitromicina, ciprofloxacina, norfloxacina, penicilina G y sulfametoxazol + trimetoprima el 48%, amoxicilina + acido clavulanico 4%, cefalexina 12%, florfenicol 24%, ceftiofur, ceftriaxona y oxacilina el 28%, cloranfenicol 32%; y entre el grupo de Staphylococcus spp: ampicilina 57.14%, sulfametoxazol + trimetoprima y tetraciclina el 52.38%, amikacina, amoxicilina + acido clavulanico, gentamicina y levofloxacina el 4.76%; cefalexina, ceftiofur, ceftriaxona y cloranfenicol el 9.52%; vancomicina 13.33%, norfloxacina 19.05%; ciprofloxacina, enrofloxacina y oxacilina el 23.81% y azitromicina 33.33%. Los perros son portadores de bacterias insensibles a varios farmacos, mismas que son capaces de transmitir genes a traves de plasmidos. Esto explica el fenomeno de resistencia a algunos antimicrobianos de uso humano, como la vancomicina, de bacterias aisladas en perros. Palabras clave: bacterias resistentes a multiples-farmacos, antimicrobianos, perros