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Through the looking glass: Basics and principles of reflectance confocal microscopy

2015; Elsevier BV; Volume: 73; Issue: 2 Linguagem: Inglês

10.1016/j.jaad.2015.04.047

1097-6787

Syril Keena T. Que, Naiara Fraga‐Braghiroli, Jane M. Grant‐Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope,

Advanced Fluorescence Microscopy Techniques

Reflectance confocal microscopy (RCM) offers high-resolution, noninvasive skin imaging and can help avoid obtaining unnecessary biopsy specimens. It can also increase efficiency in the surgical setting by helping to delineate tumor margins. Diagnostic criteria and several RCM algorithms have been published for the differentiation of benign and malignant neoplasms. We provide an overview of the basic principles of RCM, characteristic RCM features of normal skin and cutaneous neoplasms, and the limitations and future directions of RCM.