Reviews : Recognition, Treatment, and Prevention of Propylene Glycol Toxicity
2007; Wiley; Volume: 20; Issue: 3 Linguagem: Inglês
10.1111/j.1525-139x.2007.00280.x
ISSN1525-139X
AutoresTausif Zar, Charles Graeber, Mark A. Perazella,
Tópico(s)Renal function and acid-base balance
ResumoAbstract Propylene glycol is a commonly used solvent for oral, intravenous, and topical pharmaceutical preparations. Although it is considered safe, large intravenous doses given over a short period of time can be toxic. Underlying renal insufficiency and hepatic dysfunction raise risk for toxicity. Toxic effects include hyperosmolality, increased anion gap metabolic acidosis (due to lactic acidosis), acute kidney injury, and sepsis‐like syndrome. Treatment of toxicity includes hemodialysis to effectively remove propylene glycol. Prevention is best achieved by limiting the dose of propylene glycol infused.
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