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Inducible cAMP early repressor (ICER) in the nervous system – a transcriptional regulator of neuronal plasticity and programmed cell death

2003; Wiley; Volume: 87; Issue: 6 Linguagem: Inglês

10.1046/j.1471-4159.2003.02116.x

1471-4159

Barbara Mioduszewska, Jacek Jaworski, Leszek Kaczmarek,

Receptor Mechanisms and Signaling

Abstract The acronym ICER (inducible cAMP early repressor) refers to a group of four proteins produced from the CREM/ICER gene due to use of an internal promoter (P2) placed in an intron of the CREM (cAMP responsive element modulator) gene. The ICER proteins contain DNA binding/leucine zipper domains that make them endogenous inhibitors of transcription driven by CREB (cAMP responsive element binding protein) and its cognates, CREM and ATF‐1 (activating transcription factor‐1). ICER expression is inducible in the brain and in neuronal culture by a variety of stimuli. As a CREB antagonist, ICER appears to be of pivotal importance in neuronal plasticity and programmed cell death.