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Natural products inhibitors of the enzyme acetylcholinesterase

2006; Springer Science+Business Media; Volume: 16; Issue: 2 Linguagem: Inglês

10.1590/s0102-695x2006000200021

1981-528X

José Maria Barbosa‐Filho, Karina C.P. Medeiros, Margareth de Fátima Formiga M Diniz, Leônia Maria Batista, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, Emídio Vasconcelos Leitão da Cunha, Jackson Roberto Guedes da Silva Almeida, Lucindo José Quintans‐Júnior,

Medicinal Plants and Neuroprotection

Alzheimer's disease (AD) is a progressive, neurodegenerative pathology that primarily affects the elderly population, and is estimated to account for 50-60% of dementia cases in persons over 65 years of age. The main symptoms associated with AD involve cognitive dysfunction, primarily memory loss. Other features associated with the later stages of AD include language deficits, depression, behavioural problems including agitation, mood disturbances and psychosis. One of the most promising approaches for treating this disease is to enhance the acetylcholine level in the brain using acetylcholinesterase (AChE) inhibitors. The present work reviews the literature on plants and plant-derived compounds inhibitors of enzyme acetylcholinesterase. The review refers to 309 plant extracts and 260 compounds isolated from plants, which are classified in appropriate chemical groups and model tested, and cites their activity. For this purpose 175 references were consulted.