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Desenvolvimento e estudos de estabilidade preliminares de emulsões O/A contendo Cetoconazol 2,0%

2008; UNIVERSIDADE ESTADUAL DE MARINGÁ; Volume: 30; Issue: 2 Linguagem: Inglês

10.4025/actascihealthsci.v30i2.812

ISSN

1807-8648

Autores

Sílvia Regina Pengo Machado, Vanessa Catalá Casteli, Carolina Catharino Mendonça, Ingrid Condor Loureiro da Silva, Klesia Adanny Rodrigues, Márcio Augusto Leite de Campos,

Tópico(s)

biodegradable polymer synthesis and properties

Resumo

The objective of this work was the development of O/W emulsions containing Ketoconazole 2.0% and to evaluate their preliminary stability by analyzing physical-chemical characteristics such as homogeneity, aggregation formation, flocculation, creaming and coalescence. The emulsions were formulated using different self-emulsifying bases, composed of cetearyl alcohol, ethoxyl alcohol, higher fatty alcohol, stearic acid, lanolin and others. The O/W emulsions were evaluated by centrifugation test, thermal stress test, and freezing/defrosting cycles, and its organoleptic and physical-chemistry characteristics were analyzed before and after each assay. All samples maintained their homogeneity after the centrifugation test, but only the systems prepared with self emulsifying composed of higher fatty alcohol (Polawax NF® ) and ammonium acryloyl dimethyl taurate copolymer, Trilauryl 4 Phosphate, methyl glucose Sesquistearate, Summer flower oleum and Glycerin tetradibutyl pentaerythrityl hydroxyhydrocinnamate (Hostacerin NCB® ) remained stable after the thermal stress test and freezing/defrosting cycles.

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