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Adjuvant Radiotherapy Following Radical Prostatectomy: Results and Complications

1986; Lippincott Williams & Wilkins; Volume: 135; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(17)45519-4

1527-3792

Robert P. Gibbons, B. Sharon Cole, R. Garratt Richardson, Roy J. Correa, George E. Brannen, J. Tate Mason, Willis J. Taylor, Mark D. Hafermann,

Bladder and Urothelial Cancer Treatments

No AccessJournal of Urology1 Jan 1986Adjuvant Radiotherapy Following Radical Prostatectomy: Results and Complications Robert P. Gibbons, B. Sharon Cole, R. Garratt Richardson, Roy J. Correa, George E. Brannen, J. Tate Mason, Willis J. Taylor, and Mark D. Hafermann Robert P. GibbonsRobert P. Gibbons More articles by this author , B. Sharon ColeB. Sharon Cole More articles by this author , R. Garratt RichardsonR. Garratt Richardson More articles by this author , Roy J. CorreaRoy J. Correa More articles by this author , George E. BrannenGeorge E. Brannen More articles by this author , J. Tate MasonJ. Tate Mason More articles by this author , Willis J. TaylorWillis J. Taylor More articles by this author , and Mark D. HafermannMark D. Hafermann More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)45519-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Between 1954 and 1978, 148 patients underwent radical perineal prostatectomy for adenocarcinoma clinically confined to the prostate gland. This report is based on 45 of these patients with microscopic extension of disease beyond the gland and a minimum 5-year followup. Of the patients 22 received adjuvant external beam radiation therapy and 23 did not. The groups were comparable with regard to significant prognostic variables. Patient selection was by surgeon preference. Local recurrences were seen in 1 of 22 patients (5 per cent) receiving adjuvant radiotherapy and 7 of 23 (30 per cent) undergoing an operation alone (p less than 0.05). Of 8 patients with local recurrence 7 died of the disease. Delayed radiotherapy of a local recurrence generally was not effective in controlling the disease. Of the 11 patients who died of prostatic cancer with a mean followup of 9.2 years 3 received adjuvant radiotherapy and 8 did not. Severe but nonfatal long-term complications were seen in 14 per cent of the irradiated patients and 6 per cent of those treated with an operation alone. Most of the complications occurred in the earlier years of the study in patients who received 60 cobalt radiotherapy. When clinical stage B cancer of the prostate is found to be pathological stage C following radical perineal prostatectomy, adjuvant radiotherapy can decrease the incidence of subsequent local recurrence. The potential risk of adjuvant radiation therapy should be weighed and its use considered, particularly in patients whose tumor extends to the surgical margins or who have seminal vesicle invasion. © 1986 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySHI Y, BRANDS F, CHATTERJEE S, FENG A, GROSHEN S, SCHEWE J, LIESKOVSKY G and COTE R (2018) HER-2/NEU EXPRESSION IN PROSTATE CANCER: HIGH LEVEL OF EXPRESSION ASSOCIATED WITH EXPOSURE TO HORMONE THERAPY AND ANDROGEN INDEPENDENT DISEASEJournal of Urology, VOL. 166, NO. 4, (1514-1519), Online publication date: 1-Oct-2001.GROSSFELD G, TIGRANI V, NUDELL D, ROACH M, WEINBERG V, PRESTI J, SMALL E and CARROLL P (2018) MANAGEMENT OF A POSITIVE SURGICAL MARGIN AFTER RADICAL PROSTATECTOMY: DECISION ANALYSISJournal of Urology, VOL. 164, NO. 1, (93-100), Online publication date: 1-Jul-2000.LEIBOVICH B, ENGEN D, PATTERSON D, PISANSKY T, ALEXANDER E, BLUTE M, BERGSTRALH E and ZINCKE H (2018) 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Volume 135Issue 1January 1986Page: 65-68 Advertisement Copyright & Permissions© 1986 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Robert P. Gibbons More articles by this author B. Sharon Cole More articles by this author R. Garratt Richardson More articles by this author Roy J. Correa More articles by this author George E. Brannen More articles by this author J. Tate Mason More articles by this author Willis J. Taylor More articles by this author Mark D. Hafermann More articles by this author Expand All Advertisement PDF DownloadLoading ...